Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.068 46 4.6 0.0 21 44 125 148 119 153 0.89

2 7 0.011 7.3 7.2 0.0 21 47 153 179 148 185 0.84

3 7 0.32 2.2e+02 2.5 0.0 21 44 181 204 176 208 0.86

4 7 0.031 21 5.7 0.0 18 47 205 235 202 241 0.81

5 7 0.71 4.8e+02 1.4 0.1 21 43 237 259 230 264 0.79

6 7 0.032 22 5.7 0.0 21 47 265 291 259 297 0.85

7 7 0.65 4.4e+02 1.5 0.0 21 43 293 315 288 319 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.068	46	4.6	0.0	21	44	125	148	119	153	0.89
2	7	0.011	7.3	7.2	0.0	21	47	153	179	148	185	0.84
3	7	0.32	2.2e+02	2.5	0.0	21	44	181	204	176	208	0.86
4	7	0.031	21	5.7	0.0	18	47	205	235	202	241	0.81
5	7	0.71	4.8e+02	1.4	0.1	21	43	237	259	230	264	0.79
6	7	0.032	22	5.7	0.0	21	47	265	291	259	297	0.85
7	7	0.65	4.4e+02	1.5	0.0	21	43	293	315	288	319	0.76

Coding Sequence: ATGGCAAATAATTATTTGTTTATTAATAAAAATAATATTAAAGTTGAAAAAGAATTACATACAGAACTAATTATTAAAAGTGAAATATTAGATGAAACTATTTTAATGGAAGGTGGACACATTACAAATGAAGAAGAAGGCAGCAATGATAGTGATAGTGTTGTGAGTGTAAAACATGAACCTGTTAGTGATGAAAATGATAAACACTTGTACACAATTAATTATGAAAACATTAAACTTGAACAAAAATTACATACAGAACTAATTATTAAAGATGAAACTGTTTTAGAAGAAAAATCATTTGTATGTGATGTTTGTAATAAAACATTTACTTCTCAACATAATTTAGTTGTACATAAACGTATTCACACCGGAGAAAAACCATTTTCATGTGATGTTTGTAATAAAACATTTACTCAGAAAGGTGAATTAGTTAGACATAAACGTATTCACAGCGGAGAGAAACCATTTTCATGTGATGTTTGTAATAAAACATTTACTCAGAAAAGTAATTTAGTTAAACATAAACGTATTCACACCGGAGAGAAACCATTTTCATGCGATGTTTGTAATAAAACATTTACTCAGAAAGTTGAATTAGTTAAACATAAACGTATTCAGTCCGGAGAGAAACCATTTTCATGTGATGTTTGTAATAAAACATTTAATGAGAAAAGTAATTTAGTTAAACATAAACGTATTCACACCGGAGAGAAACCATTTTCATGTGATGTTTGTAATAAATCATTTACTCAACAACATCATTTAGTTTTACATAAACGTATTCACACCGGAGAGAAACCATTTTCATGTGATGTTTGTAATAAAACATTTACTCAGAAAGGTGATTTAGTTAGACATAAACGTATTCACACCGGAGAGAAACCATTTTCATGTGATATTTGTAATAAAACATTTAATGAGAAAGGTGAATTAGTTAAACATAAACGTATTCACAATCGATAA
Protein Sequence: MANNYLFINKNNIKVEKELHTELIIKSEILDETILMEGGHITNEEEGSNDSDSVVSVKHEPVSDENDKHLYTINYENIKLEQKLHTELIIKDETVLEEKSFVCDVCNKTFTSQHNLVVHKRIHTGEKPFSCDVCNKTFTQKGELVRHKRIHSGEKPFSCDVCNKTFTQKSNLVKHKRIHTGEKPFSCDVCNKTFTQKVELVKHKRIQSGEKPFSCDVCNKTFNEKSNLVKHKRIHTGEKPFSCDVCNKSFTQQHHLVLHKRIHTGEKPFSCDVCNKTFTQKGDLVRHKRIHTGEKPFSCDICNKTFNEKGELVKHKRIHNR

Sequence clustering based on sequence similarity using MMseqs2