Cruf014608.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cerceris ruficornis
Gene Symbol
E2f2
Assembly
GCA_963989415.1
Location
OZ022519.1:18034874-18038802[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.1e-31 6.4e-27 94.3 0.3 2 65 136 199 135 199 0.98

Sequence Information

Coding Sequence
ATGCCTCGAGTAAGAAGACAAGTTGTCTTGGAAGATCCAGCTAGACCTGTCACGCCTGATATGATTGAGACCAAATTATTGaaaggggaatttttagaagatgGGTCTTTGGATGAAGTTCAGCCACAGAAGGTGGCTGAGGAAACACCAAGTCCCCACCTTCAGGATCATCAGTATGGACAAACACCTTGTTATCAAGTAACAAGAAAACCCACACAGCCTCCACCTCGAACTGaaCAGATATCAGTTCAAGCAGTAAAACGAAGACTGAACTTGGAAATGGGAACAATGGGTCCCAGCCAACCCGCTTTTAAAGCACCCAGAGGTAAACGCAGAAGATCAGGCTCGAGTTCCCTAGGAGGCCACACACCTACCAGAAGTAAAACAGTAGAGAGAACACGATATGATACATCACTGAGCTTActtacaaaaaaattcatacACTTAGTTGAAAGCAGTCAAGATGGTGTTGTAGATTTAAATGTAGCATCAGAAAAGTTGGAAGTACAGAAACGTCGTATATACGACATTACAAATGTACTAGAGGGTATCGGTATTTTGGAgaagaaaagtaaaaataatatacaatggaaGGGAGGTCAGTTACCAAATGACAGGAATGACATTGCTGATCTGAGAAGAGAGGTTGCAGACTTAGAAGCTAAAGAAAACACTTTGGACCGGTTAATCCATGGTGCTGATAAAAATCTTAGGGAACTCTGTGCAGACAGACAATACGCTTATGTAACGTATCACGATTTACGTTCGGTTCCAATGTACAAAGACCAGGCTATAATGGCAGTAAAAGCTCCACCAGAAGCTACACTGCATGTTCCACAGCCTATTAATAATCTTGGTCAACAAAAGCTTCAAATGCACATGAGGTCGTCTCACGGAGAAATAGAAGTATTCCTGTGTCCCGATGATCCTACGGGTAAAACGTCACCCAATCCGGGATACACGACGACACAGTCTGTGCCTTCGTCAAAAGAATCCGAAATACCTTACTTGCCTCCTGAATTGCTGATTAATGGGGGAAGTGCTGTTAGGGTTGAACCAGTACCTTCGCTCGAGAGTTCGTTGAATACTCGCTTGTGTACACCAGTTATATCTTCGGTTACCAGTTTAGCAGGCATGAGGGACGCACTTTTGTGTGAATCTGACGATTTTGGACCAATGGGTGGTGGCAAATTCCAACTCCAAACGGAGGATCAAATTAGTTCACCAGATCTAAGTATTCTCGATTTTGGAGAACATCTGCTGTCCTTGGAACCACCTCTCTCCGAAAATGACTATTCGTTCTCGTTAGGCACGGAGGAGGGGCTTTCGGATCTCTTTGATTTCAAATTCTAG
Protein Sequence
MPRVRRQVVLEDPARPVTPDMIETKLLKGEFLEDGSLDEVQPQKVAEETPSPHLQDHQYGQTPCYQVTRKPTQPPPRTEQISVQAVKRRLNLEMGTMGPSQPAFKAPRGKRRRSGSSSLGGHTPTRSKTVERTRYDTSLSLLTKKFIHLVESSQDGVVDLNVASEKLEVQKRRIYDITNVLEGIGILEKKSKNNIQWKGGQLPNDRNDIADLRREVADLEAKENTLDRLIHGADKNLRELCADRQYAYVTYHDLRSVPMYKDQAIMAVKAPPEATLHVPQPINNLGQQKLQMHMRSSHGEIEVFLCPDDPTGKTSPNPGYTTTQSVPSSKESEIPYLPPELLINGGSAVRVEPVPSLESSLNTRLCTPVISSVTSLAGMRDALLCESDDFGPMGGGKFQLQTEDQISSPDLSILDFGEHLLSLEPPLSENDYSFSLGTEEGLSDLFDFKF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00141059;
90% Identity
iTF_00229825; iTF_00224355; iTF_00214820; iTF_00216868; iTF_00233028; iTF_00117797; iTF_00218213; iTF_00230502; iTF_00222985; iTF_00225705; iTF_00227753; iTF_00231113; iTF_00219596; iTF_00225036; iTF_00231788; iTF_00217549; iTF_00228461; iTF_00963661; iTF_00215502; iTF_00760785; iTF_00964276; iTF_00223669; iTF_00226389; iTF_00961622; iTF_00216183; iTF_00214200; iTF_00220377; iTF_00218906; iTF_00222331; iTF_00232412; iTF_00962300; iTF_00221053; iTF_00221725; iTF_00229150; iTF_00227071; iTF_01255330; iTF_00084323; iTF_00085959; iTF_00360010; iTF_00087723; iTF_00086893; iTF_00085077; iTF_00683963; iTF_00088573; iTF_00684606; iTF_00360703; iTF_00183747; iTF_00183092; iTF_00965846; iTF_00865118; iTF_00024434; iTF_00983428; iTF_01497988; iTF_01068769; iTF_01065346; iTF_01069443; iTF_01070149; iTF_01067403; iTF_01068077; iTF_01066035; iTF_01066739; iTF_00141059; iTF_00141633; iTF_00142277; iTF_00140381; iTF_00866503; iTF_00873607; iTF_00982759; iTF_00982083; iTF_01424167; iTF_00675818; iTF_00762347; iTF_00861681; iTF_00860179; iTF_00763034; iTF_00860922; iTF_00863071; iTF_00633421; iTF_00391085; iTF_00625295; iTF_01418159; iTF_01419441; iTF_01418806; iTF_01420090; iTF_01420731; iTF_00864435; iTF_01122227; iTF_00962984; iTF_01122876; iTF_01417502; iTF_01539396; iTF_00865805; iTF_00863754; iTF_00302832; iTF_00393393; iTF_01453879; iTF_00862361; iTF_01070847; iTF_01168965;
80% Identity
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