Cpul001193.5


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cephus pulcher
Gene Symbol
foxp1
Assembly
GCA_030142455.1
Location
JARQTB010000083.1:9519-28945[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.88 7.5e+02 0.5 0.6 21 54 164 197 156 215 0.84
2 3 1.7e-29 1.4e-26 92.5 0.3 2 81 595 668 594 676 0.94
3 3 8.7e-06 0.0075 16.5 0.0 48 82 685 714 671 719 0.85

Sequence Information

Coding Sequence
ATGTTGGATAATTTTCCGACTGGGGTCAGCACACTTTTCGCAGCGttgaagcagcagcagcaacagcatcTTCAGTCAAGGGACTCGTCCCACAACAGGGAAAGAGTGATAACGCGTGGGCGCGAGAGGgtcagcagcaacagcacAGCCAGTGGAGCCGACGGGGAGCAGCAGCAAGAGCTCACCATCGAGTACCAAGGCAATGGGAAGCTCAGTCCTACTGGGCACTCACTGACATCTGCACCGATGACCCAGCAAAAGCAGCCATTCATCACGCAACAGTCCCAGCAGCCGAGTTCCGGGGCCCCCGGGCCCCAACCAAGTCCTCATCAGAGTCCTCAGGCACCCCAGAGGGGCTCACCGCCGAATCCTACGCAGGGCCCGCCCCCAGGAGGCCCCCCAGGGGGTGGTCCACCCTCGCAGACAACGTCGCAGATGATGCTCAGCCCGGCGAGTGGCTTGCATCAGATGCAGCAACTTCTACAGCAGCACATTCTCAGTCCAAGTCAGCTGCAGTCGTTCATGCAGCAACACACGTTGTACctgcaacagcagcagcagcagcatcaccAGGACTCCTCGGAACATGCGGCTAACCAGGAACGATTCGGTTACTTTTCATCTCTGAAAAACCACCAACATCAACTGGCTGAACTCGGCCGCAAGCAGCTCGAGCAGGCTATGCAGCAGCTGCAGGAACAGCTGCAGCTCAACCTGATCCAACAGACGCATCTACTGCAGACAGCCGACAAGAAGAAAGCCTCGGCGCCGCTCCAGCAACTTGCGCTCCAGCAACAGCAATTGATACAGCAGCTTCAGATCACCCAGAGGCAGTATCTACTTCAGCAAGGCTTGGGTCTCCAGGGTCACAATCACTCTTCAGGCCTTCAGCCAGGGGACTCTCTGCCGGCATGGAAGACGACGGACGCCTCGGACGGTCCGGAGACGCATCAGAATTCGAACGCGCTGAAATCCTCGACCGGATTGAACGGTATTCTAAATTCGATAGTTTCCGGCCGACGGACGGAAATGAATGGCGGCTCCGGCTTGGATGAGAAACCACTGGATGTCTCCTGCAACGATAAGGCTCATCCGCTCTACGGTCACGGAGTTTGCAAGTGGCCCGGCTGTGAAGTTATTTGCGATGACTATCAAGCATTCCTCAAGCACCTCAACACCGAACACACCCTGGACGACAGATCGACAGCACAGGCTAGAGTGCAGATGCAGGTTGTCTCGCAGTTGGAAATACAGTTGCAGAAAGAACGCGACCGGCTGACTGCAATGATGCACCATCTTCACGTGGCCAAGCAGATGGCCTCGCCCGAACCGCCAAAATCCTCGGAATCCTCGACGGGATCGAGTTTACCGAAGCTGAATCTCTCCTCGGCCTTGATGAGTCAACCACCATCGAACTTTGGCGTTTCCCAGGTCTCGCCAGTCTCGATGTCGGCCCTCGTTTCTGCCGTGAGGTCACCGGCGGGAGGACAACTTCCGCCATCAGCGGGTGGTGCCCCGATGCCGCCGATACCGAACCTCTCGAACATGTCAGGCATACCACCGATGCCAAACATGCCCGGCAGCATGCCGAGCATGCCCAGTATGCCGAGTATGCCCAATATGCCAAGTATGCCCAGTATGGCTGGACCCATAAGAAGGCGAATCAGCGATAAATCGGCACTCTCTCTGGCTGGAGGGCTGCCCTACATGCTGGAGCGTGCTGGTCTTGACGTCCAACAAGAGATACAACGGAATCGGGAATTTTACAAGAATGCTGATGTGCGGCCACCCTTCACATACGCTTCATTAATTCGACAGTCGATAATCGAGTCGCCGGATAAGCAACTGACGTTGAACGAAATCTACAACTGGTTCCAGAATACATTCTGCTACTTCAGACGTAACGCAGCCACGTGGAAGaaCGCAGTGCGACACAACCTGTCTCTCCACAAATGTTTCATGCGAGTCGAAAACGTGAAAGGGGCCGTTTGGACGGTGGACGAAGTGGAGTTTTACAAGAGACGTCCTCAACGCGCTTGCAGCACGACTGGGTACAACGCGATCCGCACCAATCTATCATTGCACAAGTGTTTTGTGCGCTATGAGGACGACTTCGGGTCATTCTGGATGGTGGACGACGCCGAGTTTGTAAAGCGGCGGCATCTATCCCGCGGCCGCCCCAGGAAATATGACCCAACCCCATCACCCACTCCACCCCACCTCTCCGCACAGGGTGTCCCGTCCAAGAGCCCCACGCTAACCCACAGTCCAACGATGTATGGGGATGCACTCAACAGCAACCTCCAGTATTTCCAGGCTGCGCTCGGTGAGTCGAACATGGGCTTCCTGAACAACTCGATGTGCACGTCGACAGCGACAAGTCCTGACAAGGAGCACGTGATGGCCCACAGCGATCTGATGTCACCTTTGGATGAACCGGCGGTGCATATAAAGCAAGAGGGTCAGAGTCCCGAGGGAGGCAAGCTGTCCAGACTAATAAAGCGTGAACTCCTGGATGCACCAACGGAACAGGAGCAGGAGGAGGACCAGGTTGACGAGAGGGATTACCCGGAGAGTCACGGGCATGATTCCGGTCAGGACGAAGATATGGCCGAGGACCTCTCGATGGCACCCGACATCATGACGCCGGATGATCAGATCGAGGCGTAG
Protein Sequence
MLDNFPTGVSTLFAALKQQQQQHLQSRDSSHNRERVITRGRERVSSNSTASGADGEQQQELTIEYQGNGKLSPTGHSLTSAPMTQQKQPFITQQSQQPSSGAPGPQPSPHQSPQAPQRGSPPNPTQGPPPGGPPGGGPPSQTTSQMMLSPASGLHQMQQLLQQHILSPSQLQSFMQQHTLYLQQQQQQHHQDSSEHAANQERFGYFSSLKNHQHQLAELGRKQLEQAMQQLQEQLQLNLIQQTHLLQTADKKKASAPLQQLALQQQQLIQQLQITQRQYLLQQGLGLQGHNHSSGLQPGDSLPAWKTTDASDGPETHQNSNALKSSTGLNGILNSIVSGRRTEMNGGSGLDEKPLDVSCNDKAHPLYGHGVCKWPGCEVICDDYQAFLKHLNTEHTLDDRSTAQARVQMQVVSQLEIQLQKERDRLTAMMHHLHVAKQMASPEPPKSSESSTGSSLPKLNLSSALMSQPPSNFGVSQVSPVSMSALVSAVRSPAGGQLPPSAGGAPMPPIPNLSNMSGIPPMPNMPGSMPSMPSMPSMPNMPSMPSMAGPIRRRISDKSALSLAGGLPYMLERAGLDVQQEIQRNREFYKNADVRPPFTYASLIRQSIIESPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEVEFYKRRPQRACSTTGYNAIRTNLSLHKCFVRYEDDFGSFWMVDDAEFVKRRHLSRGRPRKYDPTPSPTPPHLSAQGVPSKSPTLTHSPTMYGDALNSNLQYFQAALGESNMGFLNNSMCTSTATSPDKEHVMAHSDLMSPLDEPAVHIKQEGQSPEGGKLSRLIKRELLDAPTEQEQEEDQVDERDYPESHGHDSGQDEDMAEDLSMAPDIMTPDDQIEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01411297;
90% Identity
iTF_01475263;
80% Identity
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