Basic Information

Gene Symbol
-
Assembly
GCA_004329405.1
Location
SJPC01002660.1:17968-24005[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 9.8 6.8e+03 -0.2 0.1 2 17 65 80 64 81 0.86
2 21 1.4 9.8e+02 2.4 9.6 2 23 289 311 288 311 0.97
3 21 0.017 12 8.5 2.2 1 23 363 385 363 385 0.97
4 21 0.012 8.2 8.9 1.5 1 23 434 456 434 456 0.98
5 21 0.025 17 7.9 0.3 1 20 507 526 507 527 0.93
6 21 7.4 5.1e+03 0.2 4.8 1 23 540 563 540 563 0.88
7 21 0.089 62 6.2 2.1 1 23 568 590 568 590 0.94
8 21 5e-05 0.035 16.4 0.7 1 23 633 655 633 655 0.97
9 21 0.00015 0.11 14.9 0.1 1 23 661 683 661 683 0.97
10 21 3.3e-06 0.0023 20.1 0.4 1 23 728 751 728 751 0.96
11 21 0.00021 0.14 14.5 2.0 1 23 757 780 757 780 0.96
12 21 2.3e-06 0.0016 20.6 1.0 2 23 787 809 786 809 0.97
13 21 0.00011 0.078 15.3 0.0 1 23 817 839 817 839 0.92
14 21 0.026 18 7.9 0.3 1 20 899 918 899 918 0.97
15 21 0.00013 0.091 15.1 0.1 2 23 938 959 937 959 0.97
16 21 0.026 18 7.9 4.0 1 23 972 994 972 994 0.97
17 21 0.0018 1.2 11.5 2.3 1 23 1016 1039 1016 1039 0.92
18 21 0.0011 0.76 12.2 1.8 2 23 1098 1120 1097 1120 0.96
19 21 0.00019 0.13 14.6 0.9 1 23 1142 1165 1142 1165 0.93
20 21 3.8 2.6e+03 1.1 4.6 1 23 1199 1223 1199 1223 0.91
21 21 0.0033 2.3 10.7 0.4 2 23 1252 1274 1252 1274 0.96

Sequence Information

Coding Sequence
ATGGAGGACGAGGACGTGGTGGAAATCGGAAACGTGGAGAATGTCTGCCGGCTATGTCTGTCCGTGGACGAACCGAGGTTCTCGGTGTTCGCGCAGGACCGAGAGGAAGATCCATCCGGTGTGCCGTTGGCCGCCAAGATACAGGCTTGCCTGTCGATCCAGATTTCAGCCACTGATAGGTTGTCTACGCTGATATGCACAAATTGTGTAAAGAATGTTAATCAATGGCATACCTACAAGGAGTCATGTCAGCGTTCACAGGACAAGCTGCAAGAATGGCTGGCAACTCAGTCGCAACCAAATCCTACAGTTATAACAATCAAGGATGAACCAATGGATATTGATTACGAGGACAATATAGAGATTATCTCAGAAATTACCAATAACTTGGATCAAGAAtattCATCAGCTCAAACAATGGAAAATAAGGAGACTGATAATAAGGAAGTGCAAGAAATAATAGATGAAACTGATACAGAAACTGATGCGAAAACTGATGCGGAAACTGACACAAGAACTGACGCGAAAGTTGATGCACATAAAGAGGATGATTCGGAAACAGTTCCATCTGCCACTGAGATGCAGCTTGATAAAGATCAAGATCAAATGGGTCAGCAGGATTCTACAGTTCTACgttctattaaaattgaacCACAGGATGACGATGACACCGATTGCACTATCGAAGTAGAATCCACAAACGGCagtgaattattattgaatccTATGGCAGTTGCCGCAAAGGAAGATACGGTTATGGAGGCTGATTCTACGCAAAAATCTAATGCGGCTAGCGTGCCGCCCAAAAAGAAACTTAGACGCGGTCCTCATACTCATTTCAGAGGAACGCGTGTCTTCAAAAAGAAATGCACGCATTGTCAGATTTTCTTGCATTCCAAACATTCATACATGAATCATATGAAGAGATTCCACAGTAAGGAAAACAATGGTATCGACAACTTGGAGTCGATATCACAGAATGACGACGAAGAGATGGTGGAAGATTTAGAAGACGAGTTGGTTAGTATGGAAAAGGACTCGCCACTAACGCAGGTCCAACAGGAGATTATCAGCCAATTGAAAACATTCTCCTGCTATTCCTGTGAGCAGACATTTAACGATCGGCGTAGCACGCTTTCTCATATACGCCAACATTTGCCGGACTTGAGACCGTATACGTGCATTGCTTGCTTGACTGAATTCTCCGATCGATCCATGTACCAGCTACATTGCGGCGCATCTTTTGAGTGCGCTATGAAGATTGCCCTCGTAGTGCCTAAGCATGGTAACGAGCGATACTTTACATGTAACATGTGCCTACGTTCGATGCGTGACAGAAAAGAATTGCTGAGTCACTTGTCGAAACATTCTGACAAACAGTACGAGGAAATGATGTCGCCGGCACGTGCGCCACCCAAACTGAAACCAATGGCGCCGTTGCCATCTGCAAGAAGCAGTTCCGATAAAGCGCAGAAAGCCGTCAACGGACCTTATAAGAACGGCGATCCGGCACACAATCATGCTTGCGATCTATGTGGTATGATTTACAGATACCGACCCAATATGTTTAAGCATCGCGAATTCTGCATGCGGTTGCAGCCCGAGAATAGAACCTCGTATAAGTGCGTGCATTGTTCCATGACGTTCCTCGTGTTTAAGAAATTCCATACTCACATCACAGTTGATCACAAAAAGAAGGAGTTCACTTGCATCGTGTGCAACTCAAAATTCCGATCGCCCAGCGATTACTTGACTCATCATGAGAACCATCGCGCAACGACACGCAGCAATCGTCAGATGCAGGAGGATACGTCGCAGAACGGAGTTCAGATACCATTGAAGGAACGGAACCGAGGAGACGCCAAGTTGGCCAAGTCGAGAATTGGCGGTCAAAAATACAGTTGTGCGCTTTGCACTCAAGAATTCTCCACGAGATCTGAGCTAACGGAGCACCGAAATCTCCATCTCAAAGTAAAGATATACTCATGCGCCATTTGCCGCAGCATGTTTAGTAGCCCGGGAGCGTTAGAAATCCACATGAAGGATCATGGCATCGAGGATCCGAATGAACGAAACGCCAATATCTCTTGCGTAGAGTACGGTAGTTTAGATGAGGACGTGAGAATCGATGAGAAAGACTCGATGAATGCGAGTGCCATCTCGGATCCCGGTACGCAGATTCACGAGTGCGGCGAATGTGGTAAGGTGCTGTCAAATTATGCCAATCTTCGCCGACATACCAAGATTGCGCATCGGAATGCCAAGATCTACGATTGTGCCGAGTGCTCGCGGATGTTTACGCGTAAGGAGCTGTATGATCACCATATGCAGATCAAACATAACTCGAAGACGATGTTGCAATGTCCTCAATGTCCCAAGAGTTTTGTCTTCCAGTCGAACTTTACTTATCATTTTCGGACTGCCCATCTTGAGAAATCGCAAAACGGTTATGCATGCGACATCTGCGGCAAAGTATTCGTCGAGGAGGCATCTCTGAAAATACACAAGGGTTGGCATAATCGTGCCAACTCTCGTCTGAGCACACGATATATATTGAGCAATCAGAAGACACCCGATGATGAGTCGCAAATGGAGCCGGTAGAATCAGGCGAGAATTCGGAACGGCCAGCAAGAGCACGAAAATCATTCCCCAATCCCCCGCTTCAATCACCGACAACTTCATCGGAGGGAAATTTTCAGTGCCAAGTATGCAATGATAAGTTCAACGATGTCACGGAGCTGAGAAATCATCTATGGGATGTCCATTGCGCCCGCAACAAGCCGGAGAAGAATTTCTGCAACGATGAACTCCAGTGCGAGCTCTGTACGAACGTCTTTCCCGATCGGGAGACCTTGGCATCACACATGCGGTGGCATAAGGCCAATCCGATTCTCAGCGACATACGAAAGACGTACTCTTGCGATGTGTGCTGTAAATCTTACAGCTCGAAGAAGGTCTTGTGGAAGCATAAAAAGCTACACAAGGCTACGGTCGTGGCATCGATCAAATTTCAATCCTTAGCCAGGAAACCGATGGCCAGTCAATTTCTTTGCAACTTTTGCCGAAAGGTCTTCTCCAGCGGCCAATCGTTACAACGGCATAAGCTCAACTTTCATAGTGAGCTGCAAAACCCGCAACGAACGCAGCAACAATTATACAATAGCAATCGTAGATTGTCGTATGAGGATGAGCCGAGAACGAAGCGTATGAAGCTCGAGATCGATGACGACAATCCGCCTAAATTGCCGCCATTTGCTATGGATTTTGCTGGCGAGAGGAGGAAACCGGTTATGTGCCACTTGTGTAAGAAGATGTTCCCGAATATGAGCGTGCTATACAAGCATAAGCAGACCGTACATAAGCATCGAGCAAGGAAGGATTTGATATTTGAGTGCATACCGATGCCGACTCAAGATGGCAAGTACTCGTGCAACATCTGCTTCAAGGAGTTCCCAGGCCTGTCAAATCTGCGACAGCACTTTACGATCAAGCACAAGAAAGGCTCGGAATCCGGCCATCCGTCGCCGAGCGGCGACACACTCTCCGAACGACCAACGAAGGAAACTGAGTCGCCGGCCCATAAAAGCATCATGTTCAGCTGCAAGCTCTGTAAACAGTGTCATGTCTTCAATAGAGAAACGCTCATGAATCACATCACCACTGTGCACAACGCGGTATACCAAGCTGATAGCAGGACGTTTCATAGGGAAATCAATCTGGGCGCTTACGTAGTGAAGGGCGCGATCGGCGCTACGTGCCCACGATGCAACGTCAAGTATCCCAACAACCGGGCTCTAAAGATACATTACATTAAGTTCCACGAGAACGCTGATTAA
Protein Sequence
MEDEDVVEIGNVENVCRLCLSVDEPRFSVFAQDREEDPSGVPLAAKIQACLSIQISATDRLSTLICTNCVKNVNQWHTYKESCQRSQDKLQEWLATQSQPNPTVITIKDEPMDIDYEDNIEIISEITNNLDQEYSSAQTMENKETDNKEVQEIIDETDTETDAKTDAETDTRTDAKVDAHKEDDSETVPSATEMQLDKDQDQMGQQDSTVLRSIKIEPQDDDDTDCTIEVESTNGSELLLNPMAVAAKEDTVMEADSTQKSNAASVPPKKKLRRGPHTHFRGTRVFKKKCTHCQIFLHSKHSYMNHMKRFHSKENNGIDNLESISQNDDEEMVEDLEDELVSMEKDSPLTQVQQEIISQLKTFSCYSCEQTFNDRRSTLSHIRQHLPDLRPYTCIACLTEFSDRSMYQLHCGASFECAMKIALVVPKHGNERYFTCNMCLRSMRDRKELLSHLSKHSDKQYEEMMSPARAPPKLKPMAPLPSARSSSDKAQKAVNGPYKNGDPAHNHACDLCGMIYRYRPNMFKHREFCMRLQPENRTSYKCVHCSMTFLVFKKFHTHITVDHKKKEFTCIVCNSKFRSPSDYLTHHENHRATTRSNRQMQEDTSQNGVQIPLKERNRGDAKLAKSRIGGQKYSCALCTQEFSTRSELTEHRNLHLKVKIYSCAICRSMFSSPGALEIHMKDHGIEDPNERNANISCVEYGSLDEDVRIDEKDSMNASAISDPGTQIHECGECGKVLSNYANLRRHTKIAHRNAKIYDCAECSRMFTRKELYDHHMQIKHNSKTMLQCPQCPKSFVFQSNFTYHFRTAHLEKSQNGYACDICGKVFVEEASLKIHKGWHNRANSRLSTRYILSNQKTPDDESQMEPVESGENSERPARARKSFPNPPLQSPTTSSEGNFQCQVCNDKFNDVTELRNHLWDVHCARNKPEKNFCNDELQCELCTNVFPDRETLASHMRWHKANPILSDIRKTYSCDVCCKSYSSKKVLWKHKKLHKATVVASIKFQSLARKPMASQFLCNFCRKVFSSGQSLQRHKLNFHSELQNPQRTQQQLYNSNRRLSYEDEPRTKRMKLEIDDDNPPKLPPFAMDFAGERRKPVMCHLCKKMFPNMSVLYKHKQTVHKHRARKDLIFECIPMPTQDGKYSCNICFKEFPGLSNLRQHFTIKHKKGSESGHPSPSGDTLSERPTKETESPAHKSIMFSCKLCKQCHVFNRETLMNHITTVHNAVYQADSRTFHREINLGAYVVKGAIGATCPRCNVKYPNNRALKIHYIKFHENAD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00110015;
90% Identity
iTF_01245407;
80% Identity
-