Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.7e-13 8.7e-09 35.8 0.8 274 300 7 33 1 33 0.90

2 3 0.00087 13 5.7 4.0 122 172 33 83 31 86 0.92

3 3 0.032 4.9e+02 0.5 7.8 195 238 65 107 54 108 0.52

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.7e-13	8.7e-09	35.8	0.8	274	300	7	33	1	33	0.90
2	3	0.00087	13	5.7	4.0	122	172	33	83	31	86	0.92
3	3	0.032	4.9e+02	0.5	7.8	195	238	65	107	54	108	0.52

Coding Sequence: GGTTGCTTGTCAGAAAACGAAGATATTCAGCGTGAGGCAAATAAATTGTTagcagattataaatttaaattgcagaAAGCGGAACAAGATATGTCCACATTACAAGCAACAGTGGCTAGATTGGAAAGTCAAGTAATTCGTTACAAATCAGCTGCAGAAGCATCTGAAAAAGCAGAAGATGAATTAAAagtggaaaaaagaaagttacAGAGAGAAgtAAGAGAAACGCAAGCTCGTGTAGAAGAATTGGAAACAGCTAACTCTCATCTGCAAAGGCGATTGGATAAacttaaaaatgcaaaatcggCACTTTTAAAGGAGCTTTGA
Protein Sequence: GCLSENEDIQREANKLLADYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRETQARVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2