Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.5e-13 7.2e-09 37.8 0.5 272 300 19 47 5 47 0.82

2 3 0.00077 37 5.9 3.6 122 172 47 97 46 103 0.92

3 3 0.0036 1.7e+02 3.7 0.6 207 239 91 122 90 122 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.5e-13	7.2e-09	37.8	0.5	272	300	19	47	5	47	0.82
2	3	0.00077	37	5.9	3.6	122	172	47	97	46	103	0.92
3	3	0.0036	1.7e+02	3.7	0.6	207	239	91	122	90	122	0.86

Coding Sequence: ATGAGTTGGGGATGTAGGGGAAATGATGATAAGAGAAGTGGGTgtGGATTGTCCGACTCTGAAGATGTTCAACGAGAAGCTAATAAATTGATcgctgattataaatttaaacttcaaaaggCAGAGCAAGACATGTCAACATTGCAAGCGACAGTTGCCAGGCTAGAGAGTCAAGTGATTCGTTATAAATCATCTGCAGAAGCGTCTGAAAAAGCAGAAGACGAATTAAAAGTAGAGAAGAGAAAACTACAAAGAGAATTCAGAGAATCCCAGAGTCGTGTGGAAGAATTGGAAACTGCAAACACCCACTTGCAACGTAGATTAGACAAACTAAAAAATGCGAGATCGACTCTTTTGAAGGAGATATGA
Protein Sequence: MSWGCRGNDDKRSGCGLSDSEDVQREANKLIADYKFKLQKAEQDMSTLQATVARLESQVIRYKSSAEASEKAEDELKVEKRKLQREFRESQSRVEELETANTHLQRRLDKLKNARSTLLKEI

Sequence clustering based on sequence similarity using MMseqs2