Cruf030277.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cantharis rufa
Gene Symbol
egg
Assembly
GCA_947369205.1
Location
OX376307.1:7751008-7763612[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.9e-14 1.3e-10 41.8 0.1 5 70 856 914 853 920 0.84

Sequence Information

Coding Sequence
ATGACCACCACGATTAGGTCCCATTTTTGTGTTTATCGCGGTTGTTCGAATTCGAGGAAGTCAACGCCGAATTTAAGTTTCTATAAGTTTCCAGTAAACGACGAAAAGCGATGTCACGAGTGGATCAAAAACAGTACAAACAAAAAATTGTACCTATTAGATAAAGAAATTTTGAGAAATAAACTAATTTGCGAGCAACATTTCGAGTTGGCATGTTTCAAAGATTTTCACGGCAAAAAGAAAATGTTAGTTAACGACGCTGTACCCAACTCGCCCAGCGCAGAGAATCAAAAAAATTGGCTACAAAACATGGAAGAACCTAGCGTCGATGGAGCGGAGGAGATGGAGCAAGACGACTCGATGGAGATGGAAATAGACGAAACTGTACCAAACACGTCGATAATAGAAAACACCTCGTTTACCTCGTCTCTAACAACTTCTTTAAATACCTCGTCGGAGATGACTCCCTCGACTCAAGATTCGATGAACGAAGATATCGACTCCAAAGCCGACATAAAAATGGATGACGACGACGACGTTGTTATTTTAGACGACGACAGCACTAAAGTTGTGAAAGAATCTACGGTGGATGTGATCGATTTGGTCGATAAGTGTCGAGGTAGTGTAAACAGCAAGTGTATAAATTACGCCTGCAAATGGGGCAAGAATTTTATCAAAGCGCCTAGGTTTTGTCTAAATTTTTATCGAATCAAAAGTTCGCAGAAGAAGAAACAGGAAGTGTGTGAACAGTGTTTGGATATCGCTTTAGATCATTATGACGAATTGGCCATGGCATTGAAAAACGGTGACAATTTGATGAACTGTAACATTCCCATACGCAACGATCTTGTCGAGATAGATGATTCCGATTCGGAAGACGAAAGTGATGAAAAATGTCGGACGTATTTTAACGAAGAAAGCATGGAAATGTTAAAATCTAATTTTGATGAAGTATTGCAGAAGGTCATTGCCGATTTTAAGTTGACTGAACATTGCGATCGATCTTTGGCGTACTTAAAAGAGAAAGGGAAGGCTGTGAAAGCAAGTTACACGGAAGTGGATACCATGTTACATGATGTTCGTAAGCAGTTAGATTCAATTCATCACGATTTATATGCGGAATTTAAAGTACAATACAAATCTTTACCACCAATAAACATTGACGATAACGTTATACCGCATGTAATGCCTAAACATCCTCCACAAAAACCAGTTCCCATGAACAAAGTGATGACACCTGTCCCGAGAACAATCGTTCAACCACAAATACCAGCACAATCCACTGTATCTACCGTTGCTGCTCCCATTGAAAGAGAGCGTCGCAGCCTTCGTAAAAGCAAACAAATTTCTTATGCGGAATTGGATGATCCACACAGTTCCAACTCAAATAGTCCAATTGTAGTTGACACTGGTCTCAAGGAACCTAAGGAAATCGAAGCAATTCAAATTCCTATTGTGCCTCCAGATTTACCTCAAAAGGGTCCAATTGTAAAAACACCATTAGCTGTCGATGAATTATATTACTCTGTTTCATTTGTTCCTATGGGATCGTGGGTTAGGGTTCGTCTAGCAGATATTTTAACGCCGGGCACGTACGTGAATGGTACAAAATTAACTCAAACTATGTATTTCCTAACAATGGAAAATAAAATTTCCAAGTATCCGCTCAATCGTACAGTATCTGGTAAAGAGATCGCGTATTCATATCCTTGTAATGTGATGTTGGATGTTGGGACAAGAGTCATAGCAGTGTTTCGAGAAGCACCCGCTTCAGGTGATTTAAAAAAAGGTAAAAAGGACGTTTTTTATCCTGGAATTATTGCGGAGCCTTTGTCGTACACCAATAAATACAGATACCTAATATTCTTTGATGATGGTTATGCTCAATATGTTCACCATAACATGGTCCATCTGATTTATGATGCCAGTGAAAAGGTATGGGAGGACATGCACGTAGATTCTCGTCCTTTCATTAAAAAATATTTGGAGTCGTATCCTGAACGTCCTATGGTTAAGTTACGTAAAGATGTGAATGTACGGACTGAATACAATGGTAAATGGTGGCTGGCGAGCGTAATGAATATAGATTGTTCTTTGGTACAAATGTATTTTGAAGCATCAAATCGTGTTGAATGGATATACCGTGGTTCGACTCGACTTAATCCCATGTTCAAGGAAGAACAGGCGGCTTCGAATAGACAAAACAAGTCACGTATTCACAGGCAGTTTAATGAAACGGGACCGTACGTTCAATACACTCGGGGTGATGGAAATGATGAAAACCAGTTGTCACCGACAAAGGACTTGGAAAATACAAGAGCTGTTGCTCGGAAAAGCACTTCCAGAGCGATTATTCAACAAAGTAGTAAAATGCCTCTTACTGTTCCTTTCTTGCCCGTGGCCACAAATGACGTTGGAGTTACTCAAGCCCCCAAAGTTATTAGCAAAGTTGTTTACTTCACTCCACGTGCACAAGCCAATACAAAAAGTTTGTACGAGCCTCACGTTTGTTCATTGGCATGTAAAAATTACATTACATACGATGTGCAAAAACTGAAGGGCTATAATCCGCTCTCGAAACCATTATTATGTGGCTGGAACCGGGTGACGTACAAACACAAAGGAAAACGAGAGATAAACTACAAAGCGCCCTGCGGGCGTTTCTTACGTAACATGCCGGAGTTGCACCGGTATTTACGAATCACAAAGAGCGAAATGACAGTGGATTTGTTTGATTTTGACTTCTGGGTTCATTGTTTAGCAGAATTCGTGCTGGAAAGAAATTCGACAATCAACAAGGACATGTCCAACGGTTTGGAGAACGTGGCCATCCCGGTCGTCAATTATGTCGACAACGAAATGAACAACTTCATCAACTACTCTAACGTGCGTGAACCTCAAGAAGGTGTGCACTTGAATCTCGACGAAGAATTTTTGTGTGGATGTGATTGTGAAGACGACTGCGAGGACAAAAGCAAATGTAACTGTTGGCAGCTGACCTTGGCTGGTTTACGTTTTATGAATAATAAAAACATGTCGACAGAAAATGTCGGATACGTTTACAGACGCCTACCCGAACCTGTTTTTACCGGAATCTACGAATGCAATTCAAGGTGCAAATGTGCCAAAACGTGTCTAAATCGTGTTGTACAAAATCCACTTCAATTCAAGTTACAAGTCTTCAAAACGATCAACAGAGGATGGGGTATTCGATGTCTCAACGATATTCCTCAGGGAGCATTCATATGCATCTATGCGGGAAAAATTCTTACTGAACAAGTGGCGAACGAAGGCGGACAAAATTTCGGTGATGAATACTTGGCAGAACTTGATTACATCGAAGTGGTGGAGAAAATGAAGGAAGATTACGAGGAGGACGTTAAGGATGAACTAGACGACACTAAGAGTAGGGAATCGGGAGACGAAGACAATGATTACCTCGGCAGTATAAGGAAGAAAACCTATATGGATGATTCGGATTTTGTACCACATCAGCTCATTCCGAAAGGAAAACCCAATTCGATTTATAAGACCAGATCACGCAGGAAAGATGAAGAAGATGACACCGTCACAATTAGTGACGATGAAGATATCATCCGTGAGCCATCGAGTTTTAATCCGAAAACAGATGTGGATGATGAATCGAGGCCATCAAAATATCTTTCGGTGCGCGAAATGTATGCCGATGAGGAATGTGTTTATATCATGGATGCCAAAGTTAGAGGAAATATCGGAAGATACTTAAATCACTCCTGTTCGCCTAACGTGTTTGTTCAGAACGTTTTTGTCGACACTCACGATCTACGGTTTCCTTGGGTAGCCTTTTTTGCATTAAGTTATATTCGAGCTGGTACAGAATTAACTTGGAATTATAACTACGATGTCGGTAGTGTACCTGGCAAGACGATGTACTGTCATTGCGGTTCGCAAGAATGTCGTGGTCGCTTGCTTTAG
Protein Sequence
MTTTIRSHFCVYRGCSNSRKSTPNLSFYKFPVNDEKRCHEWIKNSTNKKLYLLDKEILRNKLICEQHFELACFKDFHGKKKMLVNDAVPNSPSAENQKNWLQNMEEPSVDGAEEMEQDDSMEMEIDETVPNTSIIENTSFTSSLTTSLNTSSEMTPSTQDSMNEDIDSKADIKMDDDDDVVILDDDSTKVVKESTVDVIDLVDKCRGSVNSKCINYACKWGKNFIKAPRFCLNFYRIKSSQKKKQEVCEQCLDIALDHYDELAMALKNGDNLMNCNIPIRNDLVEIDDSDSEDESDEKCRTYFNEESMEMLKSNFDEVLQKVIADFKLTEHCDRSLAYLKEKGKAVKASYTEVDTMLHDVRKQLDSIHHDLYAEFKVQYKSLPPINIDDNVIPHVMPKHPPQKPVPMNKVMTPVPRTIVQPQIPAQSTVSTVAAPIERERRSLRKSKQISYAELDDPHSSNSNSPIVVDTGLKEPKEIEAIQIPIVPPDLPQKGPIVKTPLAVDELYYSVSFVPMGSWVRVRLADILTPGTYVNGTKLTQTMYFLTMENKISKYPLNRTVSGKEIAYSYPCNVMLDVGTRVIAVFREAPASGDLKKGKKDVFYPGIIAEPLSYTNKYRYLIFFDDGYAQYVHHNMVHLIYDASEKVWEDMHVDSRPFIKKYLESYPERPMVKLRKDVNVRTEYNGKWWLASVMNIDCSLVQMYFEASNRVEWIYRGSTRLNPMFKEEQAASNRQNKSRIHRQFNETGPYVQYTRGDGNDENQLSPTKDLENTRAVARKSTSRAIIQQSSKMPLTVPFLPVATNDVGVTQAPKVISKVVYFTPRAQANTKSLYEPHVCSLACKNYITYDVQKLKGYNPLSKPLLCGWNRVTYKHKGKREINYKAPCGRFLRNMPELHRYLRITKSEMTVDLFDFDFWVHCLAEFVLERNSTINKDMSNGLENVAIPVVNYVDNEMNNFINYSNVREPQEGVHLNLDEEFLCGCDCEDDCEDKSKCNCWQLTLAGLRFMNNKNMSTENVGYVYRRLPEPVFTGIYECNSRCKCAKTCLNRVVQNPLQFKLQVFKTINRGWGIRCLNDIPQGAFICIYAGKILTEQVANEGGQNFGDEYLAELDYIEVVEKMKEDYEEDVKDELDDTKSRESGDEDNDYLGSIRKKTYMDDSDFVPHQLIPKGKPNSIYKTRSRRKDEEDDTVTISDDEDIIREPSSFNPKTDVDDESRPSKYLSVREMYADEECVYIMDAKVRGNIGRYLNHSCSPNVFVQNVFVDTHDLRFPWVAFFALSYIRAGTELTWNYNYDVGSVPGKTMYCHCGSQECRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00268269;
90% Identity
iTF_00272686; iTF_00268269; iTF_00269808; iTF_01291572; iTF_00271257; iTF_00271157; iTF_01293693;
80% Identity
iTF_00272686;