Cnig018350.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cantharis nigra
Gene Symbol
egg
Assembly
GCA_958510845.1
Location
OY294031.1:8691695-8699797[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.6 1.5e+04 -3.5 0.0 14 35 582 607 573 607 0.67
2 2 4e-14 1.3e-10 41.5 0.1 5 70 861 919 858 925 0.84

Sequence Information

Coding Sequence
ATGACCACCACGATCAGGTCCCATTTTTGTGTTTATCGCGGTTGTTCGAATTCGAGGAAGGCTACGCCGCACTTAAGTTTTTATAAGTTTCCCGTAAACGACGAAAAGCGATGTCACGAGTGGATCAAAAACAGCACAAACAAAAAACTGTACCTCTtagataaagaaattttaagaaacaaacTAGTTTGCGAGCAACATTTCGAGTTAACTTGTTTCAAAGATTTTTACGGCAAAAAGAAAATGCTAGTTAACGACGCCGTACCCAACTCCCCCAGCCCAGataatCAGAAAAATTGGCTACAAAACATGGACGAACCTGGCGTCGATGGTGcGGAGGAGATGGACCAAGACGACTCAATGGAGATGGAAATAGATGAAACTGTACCGAATACGTCGATAATAGAAAACACTTCGTTTACGTCGTCTCTAACAACTTCTCTAAATACCTCGGCGGAGATGACTCCCTCGAGTCAAGACTCGATCAATGAAAATATCGACTCCAAAGCCGACATAAAAATGGACGACGACGACGATGTTGTTATTTTAGACGACGACACAGCTAAAGTTGTGAAAGAACCAAAGGTAGATGTGATCGATTTGGTCGATAAGTGTCGAGGCAGTGTAAACAGCAAGTGTATAAATTACGCCTGCAAATGGGGCAAGAATTTTATCAAAGCGCCCAGGTTTTGCCTAAATTTTTATCGAATCAAAAGTTCACAGAAGAAGAAACAGGAAGTGTGTGAACAGTGTTTGGATATTGCGTTAGATCATTATGACGAGCTGGCCATAGCGTTAAAAAACGGTGATAATTTGATGAACTGTAACATTCCCATTCGCAACGATCTCGTCGAGATAGACGATTCCGATTCGGAAGACGAAAGTGATGAGAAGTGTCGAACGTATTTTAATGAAGAAAGCATGGAGATGCTCAAATCGAACTTTGACGAAGTATTGCAGAAGGTCATTGCCGATTTTAAGTTGACCGAACATTGCGATCAATCTTTGGAGTACTTAAAGAAGAAAGGAAAGGCTGTGAAAGAAAGTTACACGGAAGTGGATACCATGCTACACGATGTTCGTAAGCAGTTAGATTCAATTCATCACGATTTATATGCGGAATTTAAAGTACAATACAAATCATTACCACCGATAAACATTGACGATAACGTTGTACCACATGTACCACATGTAACGCCTAAACATCCTCCACAAAAACCAATTCCCATGAACAAAGTAATGACACctGTCCCGAGAACAATCATCCAACCACAAACACCAGCACAAGCCACCATGATGTCTTCAGCAGCGGCTCCCATTGAAAGAGAACGTCGCAGTCTTCGTAAAAGCAAACAAATTTCTTATGCCGAATTGGATGATCCGCACAGTTCCAACTCAAATAGTCCGATTGTGGTTGACACTGGTCTCAAGGAACCTAAGGAAATCGAAGCAATTCAAATTCCTATTGTACCTCCAGATTTACCTCAAAAGGGTCCAATTGTAAAAGCACCATTAGCTGTCGATGAATTGTATTACTCTGTTTCGTTTGTTCCTATGGGGTCGTGGGTTAGGGTTCGTCTAGCAGATATATTAACACCGGGCACATATGTAAATGGTACAAAATTAACTCAAACTATGTATTTCCTCACGATGGAAAATAAAATCTCCAAGTATCCGCTCAACCGTACAGTATCTGGTAAAGAGATTGCATATTCGTATCCTTGCAATGTCATGTTGGATGTTGGGACACGAGTCATAGCAGTGTTTCGAGAAGCACCCGCATCCGCcgatttaaagaaaggaaaaaagGACGTTTTTTATCCTGGAATTATTGCGGAGCCTTTGTCGTACACCAATAAATACAGATATCTAATATTCTTTGATGATGGTTACGCGCAATACGTTCACCATAACATGGTCCACCTGATTTACGATGCCAGCGAAAAGGTATGGGAAGACATGCACGTAGATTCGCGgccttttattaaaaaatatttggaatcGTATCCCGAACGTCCTATGGTCAAGTTACGTAAAGATGTGAATGTAAGGACTGAATATAATGGTAAATGGTGGCTGGCGAGCGTAATGAACATAGATTGTTCTTTGGTCCAAATGTATTTTGAAGCATCAAATCGTGTTGAATGGATATACCGTGGTTCGACTCGACTCAATCCCATGTTCAAAGAAGAACAGGCGGCTTCTAATAGGCAAAACAAGTCACGTATTCACAGACAGTTTAATgAAACCGGACCGTACGTCCAGTACACTCGGGGTGATGGAAATGATGAAAATCAGTTGTCACCTTCGAAAGACTTTGAAAATACACGGGCAGTTGCTCGTAAAAGCACTTCCAGAGCGATTATTCAACAAAGTAGTAAGATGCCTCTTACGGTTCCCTTTCTGCCTGTGGCCACCAATGACGTTGGAGTTACTCAACAAGCCCCTAAAGTTATTAGTAAAGTTGTTtactTCACTCCACGTGCACAAGCCAATACAAAAAGTTTGTACGAACCTCACGTTTGTTCATTGGcatgtaaaaattacattacataCGATGTGCAAAAGCTGAAGGGCTATAATCCGCTCTCGAAACCATTATTGTGTGGCTGGAATCGGGTGACGTACAAACACAAAGGGAAACGAGAGATAAACTACAAAGCGCCCTGCGGGCGCTTCTTGCGAAACATGCCAGAGCTGCACAAATATTTACGAATAACAAAAAGCGAAATGACAGTGGATTTGTTCGATTTCGATTTCTGGGTTCATTGTTTAGCAGAGTTCGTGCTGGAAAGAAATTCGACAATCAATAAGGACATGTCCAACGGTTTGGAGAACGTGGCCATCCCGGTTGTCAACTATGTCGACAACGAAATGAACACCTTCATTAACTACTCAAACGTGCGCGAACCTCAAGAAGGTGTGCACTTGAATCTCGATGAAGAATTTTTATGTGGATGCGATTGCGAAGACGACTGCGAGGACAAAAGTAAATGTAATTGTTGGCAGTTGACCTTGGCTGGTTTAcgttttatgaataataaaaacatgTCGACTGAAAATGTCGGATACGTTTACAGGCGGCTACCCGAACCTGTCTTTACTGGAATTTATGAATGCAATTCAAGgtgCAAATGTGCCAAGACGTGTCTAAACCGTGTTGTACAAAATCCACTTCAGTTCAAGTTACAAGTCTTCAAGACGATCAACAGAGGTTGGGGTATTCGATGTCTCAACGACATTCCTCAGGGAGCGTTCATATGCATTTACGCgggaaaaattttaactgagcAAGTGGCGAACGAAGGGGGTCAAAATTTCGGTGATGAATACTTAGCTGAACTTGATTATATCGAAGTGGTGGAGAAAATGAAGGAGGATTATGAGGATGACGTTAAGGACGAGGAACTAGATGACACTAAGAGTAGGGAATCGGGCGACGAAGACAATGATTATCTCGGCAGTGTAAGGAAGAAAACGTATATGGATGATTCGGATTTTGTACCACATCAGCTCATTCCTAAAGGAAAACCCAATGCGATTTATAAgaCCAGATCACGCAGGAAAGATGAAGAAGATGACACCGTCACAATTAGTGACGATGAAGATATAATTCGTGAGCCGTCAAGTTTTAACCCAAAGACAGATGTGGATGACGAATCCAGGCCATCGAAATACCTTTCGGTGCGAGAAATGTATGCAGAAGAGGAATGCGTTTATATCATGGATGCCAAAGTTAGAGGAAACATCGGAAGATACTTAAATCACTCCTGTTCACCCAACGTGTTTGTTCAAAACGTTTTTGTCGACACTCACGACTTACGGTTTCCTTGGGTAGCCTTCTTTGCATTAAGTTACATTCGGGCTGGTACAGAATTAACTTGGAATTATAACTACGATGTGGGTAGTGTTCCTGGCAAGACGATGTACTGCCATTGTGGTTCGCAAGAATGTCGTGGTCGATTGCTTTAA
Protein Sequence
MTTTIRSHFCVYRGCSNSRKATPHLSFYKFPVNDEKRCHEWIKNSTNKKLYLLDKEILRNKLVCEQHFELTCFKDFYGKKKMLVNDAVPNSPSPDNQKNWLQNMDEPGVDGAEEMDQDDSMEMEIDETVPNTSIIENTSFTSSLTTSLNTSAEMTPSSQDSINENIDSKADIKMDDDDDVVILDDDTAKVVKEPKVDVIDLVDKCRGSVNSKCINYACKWGKNFIKAPRFCLNFYRIKSSQKKKQEVCEQCLDIALDHYDELAIALKNGDNLMNCNIPIRNDLVEIDDSDSEDESDEKCRTYFNEESMEMLKSNFDEVLQKVIADFKLTEHCDQSLEYLKKKGKAVKESYTEVDTMLHDVRKQLDSIHHDLYAEFKVQYKSLPPINIDDNVVPHVPHVTPKHPPQKPIPMNKVMTPVPRTIIQPQTPAQATMMSSAAAPIERERRSLRKSKQISYAELDDPHSSNSNSPIVVDTGLKEPKEIEAIQIPIVPPDLPQKGPIVKAPLAVDELYYSVSFVPMGSWVRVRLADILTPGTYVNGTKLTQTMYFLTMENKISKYPLNRTVSGKEIAYSYPCNVMLDVGTRVIAVFREAPASADLKKGKKDVFYPGIIAEPLSYTNKYRYLIFFDDGYAQYVHHNMVHLIYDASEKVWEDMHVDSRPFIKKYLESYPERPMVKLRKDVNVRTEYNGKWWLASVMNIDCSLVQMYFEASNRVEWIYRGSTRLNPMFKEEQAASNRQNKSRIHRQFNETGPYVQYTRGDGNDENQLSPSKDFENTRAVARKSTSRAIIQQSSKMPLTVPFLPVATNDVGVTQQAPKVISKVVYFTPRAQANTKSLYEPHVCSLACKNYITYDVQKLKGYNPLSKPLLCGWNRVTYKHKGKREINYKAPCGRFLRNMPELHKYLRITKSEMTVDLFDFDFWVHCLAEFVLERNSTINKDMSNGLENVAIPVVNYVDNEMNTFINYSNVREPQEGVHLNLDEEFLCGCDCEDDCEDKSKCNCWQLTLAGLRFMNNKNMSTENVGYVYRRLPEPVFTGIYECNSRCKCAKTCLNRVVQNPLQFKLQVFKTINRGWGIRCLNDIPQGAFICIYAGKILTEQVANEGGQNFGDEYLAELDYIEVVEKMKEDYEDDVKDEELDDTKSRESGDEDNDYLGSVRKKTYMDDSDFVPHQLIPKGKPNAIYKTRSRRKDEEDDTVTISDDEDIIREPSSFNPKTDVDDESRPSKYLSVREMYAEEECVYIMDAKVRGNIGRYLNHSCSPNVFVQNVFVDTHDLRFPWVAFFALSYIRAGTELTWNYNYDVGSVPGKTMYCHCGSQECRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00268269;
90% Identity
iTF_00272533;
80% Identity
iTF_00271257;