Basic Information

Gene Symbol
-
Assembly
GCA_949152465.1
Location
OX424439.1:2061141-2062819[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.037 2.4 9.9 1.3 1 23 124 146 124 146 0.99
2 13 0.0064 0.41 12.3 1.0 3 23 154 173 153 173 0.95
3 13 8.8e-05 0.0056 18.2 2.8 3 23 180 200 178 200 0.97
4 13 5.6e-05 0.0036 18.8 3.9 1 23 205 227 205 227 0.98
5 13 0.0028 0.18 13.4 0.0 2 21 233 252 232 253 0.94
6 13 0.00019 0.012 17.1 1.1 1 23 260 282 260 282 0.97
7 13 3.6e-06 0.00023 22.5 2.4 1 23 288 311 288 311 0.97
8 13 0.067 4.3 9.1 0.1 3 23 334 353 333 353 0.95
9 13 1.2e-05 0.00079 20.8 2.1 2 23 359 380 358 380 0.97
10 13 0.00048 0.031 15.8 5.7 1 23 385 407 385 407 0.99
11 13 0.00036 0.023 16.2 0.5 2 23 416 437 415 437 0.96
12 13 0.0061 0.39 12.4 4.5 1 23 443 465 443 465 0.98
13 13 0.0014 0.091 14.4 0.4 1 23 471 494 471 494 0.97

Sequence Information

Coding Sequence
ATGGAATTTGAATGCCGAACGTGTTTAAAATTGTCTACCAATGTGAGCCACGTATATTCAGATGATTTACCTCATAAAATAGAAACGATAGCTTCGGTCGAGGTTTTGGAAAGCGACAAGTTTTCGTCTAAAATATGCGAAGAATGCTTAACCAACGTGAACCAGATGTACGAATTTCGTAAAGTCATCAGATCGAGTAACATGATTTTAATGAAACGTAGCATGAAGGAAGAGGAGGCGGTTACCTCGCTAAATGAAGATACTTTCGAAACGGAACTCGAATTAAAAGAGGAAGACATTTCAGATTATTACGAAAACGAGGACGACGAAATCGAAACGCCTGTGACTACTAATGTGAAAGAAAACATATTCAAGTGCATGCAGTGCGATTTCACCAGTCCCGACTGCGATTTATGGGTGGCTCATCAAAAGAGACACAAAAAAACCAAGCTAGCTAATTGTGACATTTGCGGAAAATCAGTTATAAGCTATAATCTTAAAAGGCATCACCTCATCCATACAGAATCTCCGATGAATTGTCCAATTTGTGGAACAGTGTGTAAGCACGAGGAATCATTAAGGTCGCACATGTTTACGCACAGAAACGGTCCATATACTTGTACAATATGTGGGAAAGTTTATCGACACAGACAAAGTTACAATGCTCACAAGAAACAACACACAgagtATACAATGGAATGTGCAACATGCGGAAAATTATTTTCCGATAAAACATTGCTGAGTGATCATATTAATGCTCGCAactgtgaaaaaaattttccttgtAAATTTTGCGATAAAGGTTTCACTAGTAATTCTGCTCGAAACACACACGAGAGGCTTCATACCAACGAAAAGCCATTTTCGTGTGATCACTGCGATGAGGTTTTCTCCCAGAAGGTTTCGTTGCAAACGCACCTAAAATCTAAACATCCTAACGAAGAAATCATAGATTTGCCAAAGGaacaaaagaaatcaaaaatatacaagCAGGCTATTTGTAGCATTTGCGGAAAATCAGTTATAAGTTACAACATCAAAAGGCACTACCTGATCCACACAGACTCGCCGGTCACGTGTAAAATTTGTGGGAAAGTTTGTAAGCACGAGGAATCGTTACGAGCGCATATGTATGTGCACAACAAAGGCCCATACCGGTGCACGCTATGTGGGAAGTTTTATCGACACAGACAAGATTACAACGCTCACAAAAAACGACATGCATctggAAATGCCAAGACTATAGAATGCTTAACATGCGGAAAACTGTTTTATAATAAGACTACGTTGGTGAGACATATTTATAGTCACACCGGTGAACGACCCTATCCGTGTAAGTTTTGCAACAAAGGATTCACCAGCACTCACGCCCGAAAGACGCACGAACGGCGGCACACAAACGAAAAGCCTTTTTCGTGTAATTTTTGCGACGCGGCTTTTCCCCAGGGAGTCTCCTTACGAACGCATCTTAAATCGAAACATCCTGACCAAATAATTGTTAACGAAGATATTGCagagtaa
Protein Sequence
MEFECRTCLKLSTNVSHVYSDDLPHKIETIASVEVLESDKFSSKICEECLTNVNQMYEFRKVIRSSNMILMKRSMKEEEAVTSLNEDTFETELELKEEDISDYYENEDDEIETPVTTNVKENIFKCMQCDFTSPDCDLWVAHQKRHKKTKLANCDICGKSVISYNLKRHHLIHTESPMNCPICGTVCKHEESLRSHMFTHRNGPYTCTICGKVYRHRQSYNAHKKQHTEYTMECATCGKLFSDKTLLSDHINARNCEKNFPCKFCDKGFTSNSARNTHERLHTNEKPFSCDHCDEVFSQKVSLQTHLKSKHPNEEIIDLPKEQKKSKIYKQAICSICGKSVISYNIKRHYLIHTDSPVTCKICGKVCKHEESLRAHMYVHNKGPYRCTLCGKFYRHRQDYNAHKKRHASGNAKTIECLTCGKLFYNKTTLVRHIYSHTGERPYPCKFCNKGFTSTHARKTHERRHTNEKPFSCNFCDAAFPQGVSLRTHLKSKHPDQIIVNEDIAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00269403; iTF_00270244;
90% Identity
iTF_00269403;
80% Identity
iTF_00269403;