Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_900659725.1
Location
CAACVG010002203.1:1486574-1528453[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.2e-11 4.6e-08 32.7 0.0 2 69 293 359 292 367 0.91
2 2 3.3 1.3e+04 -4.0 0.1 47 65 882 900 881 901 0.81

Sequence Information

Coding Sequence
CTTAAAATTTCTTCTACAGAAGAATCAACTGAGGAATCAAATCAGACAATAGAAGATGTTAAAATAAAACCCAAAGAGGAAAAACTAGATAACAAAGAGCAACCATCAACTGACCAGCTCTCTGCTGTGAATAATTCAGACTTGATTGACTTTACAATCAACAACCGGATTGAAGCATTAGACTTCAACCAGGAATGGTATCCAGCAAAAATCTTGGAGGTGGACCACCAAGAGAATGAAGTGCTGATCCATTTTGAAAAGTTCTCCAGTAAGTATGATGAATGGGTGAGCATGACAAGCTCAAGACTACGTCCAATGCAGCAGACCAATGAGACCATAGAACCTGTAATAACAGCTCCACCAGCAAGTATTAAGGTTGCTGGTACAACACATCAGTTTGAAGTTGGTGAGAGATGTTTGGCTGCTTGGAGCAACTCTCAGAAGTTCCCTGCAACTGTGTCTAAAGTTTTGGAGAATAACACATACGAAGTCCTGTTTGATGACGGCTTCGTAAAGACATTGAAGGGACACCGGATGTCGAAGACGGGCAGCAAGCCTTTGCAAGCGTCGCCGTTGTTTGAGCCGATTAAGAGTAGCAAGCAGGATCGCAgggaaaagaagaagaagctgaACGTAGCGTCGCTGTTCAAGAAACGACAGCGTGGCACCGGTGGCAGTGGAAGTGGAGGGGAAGCCAGTGCCGAAGGAGAGAAACCCACCAAGAAGGTTAGGCACAAGGCTGAGCCTTCGACCTTGGCTACTATACCCGCAGCCGCCGATACTGCTGTCGATGATGTACAGAACTGGAGGCCtttGTGGCACAAAGGCAGACCTGTTGGTACTGATGCAATGCTAGAGACAGGCGACGGACTGAAGCACACTGTCATTGTGCCTGATCCGCGGCTTCCAGAAGGCTGGGCGAAGCATTTGCTGCGTAGGAATATTAagggaggtggcgtcaaatgGGACACCATAATTACCAGTCCTGAAAATAGAAGATTCAGATCGAAGCACGAAGTGCGCGTCTTCTTAGAAGCCAACCCGACAGAAGGTCTGAACGTGAACATGTTTGATTTCTGTCTGGTCAGATCTAAGCCCAAAAAAGTCAAACAACCACCCGTAGAGACACCTGAAATGCCTCCTGAACCGGCACCTGTCGTAGAGCCGCAAGATGATTCGCAGATGATAGAAGAGCAAGACTCCCAAGATGAAGATAACTCTAATAGTCTGAAGATCCTATTTGAAGACAATGCATATAAGTGCCCCATTGAAGGGTGTGGTAAGAACTTCCGCAGGGAGAACCTAGCACAGATGCATGTTAAGCACTACCATCCAGAATACACCAAGTTCCTTGATTCTACGCCTAACGTAGCAGATTTAGCTTATGCTAGGACAGTTGGGGAAAATCTCGACAAATCGCCAGGTCCGTCAAGTAGACCTCCGGTATTGAAACCAGCTGTGAAGGCATCAACACCAAAGGCGTCAAAGTTGACTCAATCTCCACACTCAGAGATGGCGGATTTGAGACCAGCTGGCGCTCAGTCGCCCAGTATAAGCAAGTCCAAGGATGCCGAAATCATAAAGTTATTGAATTCGAAACCATCTGACAAAAAGGAGTCGGATATGACACAGAGCCATTCTCTTGGGATACCGCCAGGCGGATATCCAGACTTGAAGTTGAAGGATCTGCTGAGCAAGTCTGAAGGTGTACCGAAAAGGGACGAATTCAGCAAGTCGTTTGCTGCTAGTCGACCTGCTGGCATCAAGACCTTGCTTCCTGTTGCCAGGCAGCAAGCCGGTGATTCTGCTATGAGCCAACAACAGCAACAGCAGCAGCCCTCGCCGGACCTCCCACCCGCGACCGGCAAACGTAAACGCGTCACCTCCGACAACGCAGATCATACCGGCGCCAGGAGCAAACATCCCCGTTCCACTCCCCCGCCCTCCCAAACAACCGAGCAGCCCCCCTCCTCGCTGTCCCCCGCCTCCGTCCAACATCCGATTCCTGTCACCGGCGACAACTCTGTCGATCCGCTCCCTACCGCCCAACCCGCGACGGCCGCTCCCCTCCCCGAGGATCCTCCCGACTCCTCCAAACCCGACCTTCCCCCTAACAATATCATCATTGAAGGTGGCGAGGTGATCAAGATCGTCCGCATGAAGCAGGAGGAGATCATCAACTGCACGTGCGGCTACACCGAGGAGGACGGACTTATGATACAGTGCGAGCTGTGTCTCTGCTGGCAGCACGCTTATTGCAATAATATCGAGAGGGAGAGTCAGGTACCTGAGAAGTATATATGTTACATCTGCCAAAATCCGTTCAGAGAGCGACTGTCTCGCAAGTACTATCATGATCAGGATTGGTTGAAGCAGGGCATTCTTCCAACCGGTAGCTACCACTCCAGAGATGAAGAACAGTTACAGAAACGatttgaaaagctaaaaaaGTGCCATGATTTATCTGGCGGTTTGCAGGAACTCAAAGATTACATGCACAGCCTCGCAATCAAGCTCAAGATTGCTGAAATGAAGAATCATCCAAAATTGTACCTGTGGGCGAAAATGTGGGAGAAGAATTCGCTTCCCGAAAAAGTGAAAGAAGAATGCGATGAAACTAAGCACAAAATagaaaacatagaaaacgaaGATCATCAATACATAAAAACGAATGACCCCGAAAAACAAGAGAAACCCGACGATGCTATGCTAATGATGATTCTTAAAGCGGGAAAAGAGGTGATGCCAAAGTTAGATCTGAATTTGCTGATGGATAACAACATGAGCCAGCTCCCCATCATCCCTCAACCAGAGGCTGCGATCGACTCGAGCGTCTGTAGGGATAACCTGCTTCACCACATCCGCCACCAGGAGTCTCTAGTCGAGGAGagGTTGGATGACTTCGAGAAACAAATAGACGCATTGGAGGAGTGTATGGACATGGAGGTGGATATgaactatcccaaaatgagGCACTCCTTGCAGATGCTCGCCAGGGACCTGGAGAAGTTGAAAGAGTTCAGTCACACCACTACCATATGA
Protein Sequence
LKISSTEESTEESNQTIEDVKIKPKEEKLDNKEQPSTDQLSAVNNSDLIDFTINNRIEALDFNQEWYPAKILEVDHQENEVLIHFEKFSSKYDEWVSMTSSRLRPMQQTNETIEPVITAPPASIKVAGTTHQFEVGERCLAAWSNSQKFPATVSKVLENNTYEVLFDDGFVKTLKGHRMSKTGSKPLQASPLFEPIKSSKQDRREKKKKLNVASLFKKRQRGTGGSGSGGEASAEGEKPTKKVRHKAEPSTLATIPAAADTAVDDVQNWRPLWHKGRPVGTDAMLETGDGLKHTVIVPDPRLPEGWAKHLLRRNIKGGGVKWDTIITSPENRRFRSKHEVRVFLEANPTEGLNVNMFDFCLVRSKPKKVKQPPVETPEMPPEPAPVVEPQDDSQMIEEQDSQDEDNSNSLKILFEDNAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGENLDKSPGPSSRPPVLKPAVKASTPKASKLTQSPHSEMADLRPAGAQSPSISKSKDAEIIKLLNSKPSDKKESDMTQSHSLGIPPGGYPDLKLKDLLSKSEGVPKRDEFSKSFAASRPAGIKTLLPVARQQAGDSAMSQQQQQQQPSPDLPPATGKRKRVTSDNADHTGARSKHPRSTPPPSQTTEQPPSSLSPASVQHPIPVTGDNSVDPLPTAQPATAAPLPEDPPDSSKPDLPPNNIIIEGGEVIKIVRMKQEEIINCTCGYTEEDGLMIQCELCLCWQHAYCNNIERESQVPEKYICYICQNPFRERLSRKYYHDQDWLKQGILPTGSYHSRDEEQLQKRFEKLKKCHDLSGGLQELKDYMHSLAIKLKIAEMKNHPKLYLWAKMWEKNSLPEKVKEECDETKHKIENIENEDHQYIKTNDPEKQEKPDDAMLMMILKAGKEVMPKLDLNLLMDNNMSQLPIIPQPEAAIDSSVCRDNLLHHIRHQESLVEERLDDFEKQIDALEECMDMEVDMNYPKMRHSLQMLARDLEKLKEFSHTTTI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00249015; iTF_00248962;
90% Identity
-
80% Identity
-