Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_949316355.1
Location
OX438532.1:14076046-14086371[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3e-12 9.3e-09 35.0 0.1 3 69 413 478 411 486 0.90
2 2 3.5 1.4e+04 -4.1 0.1 46 61 986 999 983 1006 0.76

Sequence Information

Coding Sequence
ATGGGGCGGAAATGCAGTGTAGAAAGCTGTCTGTCCGACTCCAACAGACCTGAAGACATGGGGGTAACATTTCATAAGGTACCGATGCACCCTGACGTAAGACCGAAATGGATGTCTTTGTGCCATATACCGGACGATAAAAAGACCGTCAAGATAATCTATGTTTGCTCAAGGCATTTCTTGCGCGCGGACTTTTGTAATTTCAAAGGAAAGAAGTACATGCTGAGACAAGGAGTGCTACCTAGTGTCTTTCCTTGGGATAAGTCGAGACTCGAGGCTATCAAAGCCGAAGCTACAGTCAAGAAGGAGAAAAACATGGATGAACCAAACGCGGATGTGATGAAGGGCGAGTTGGAGGAGTCTACTTTGGATATCAAGTCCGAAGAATCTACTGAGGAATCAAATCAAACAATAGAAGATGTAAAAGGAGAGCCCAAACAGGAAAAACTGGAAGATAAACAACAACCACCTGGAGATCAACCATCTGCCATAAATAATTCAGACTTGATTGATTTCACAATCAACAACCGAATTGAAGCTTTGGACTTCAACCAAGAATGGTATCCAGCAAAAATTTTGGAAGTAGACCATCAGGAGAATGAAGTACTGATCCATTTTGAGAAGTTCTCGAGCAAGTATGATGAATGGGTGAGTATGGAAAGCTCAAGGTTGCGTCCGATGCAGCAAACCGCAGTACCTGAAACAACAGCTTCACCAGTGGGGAGGAAAGTTACTGGTATGACAGATATGTTTGAAGTAGGCGAGAGATGTCTGGCTGCCTGGAGCAACTCCCAGAAATTCCCTGCAACTGTGTCCAAGGTGTTGGAGAATAACACATACGAGGTCCTGTTCGACGACGGTTTCGTAAAGACCTTGAAGGGTCACCGGATGTCGAAGTCGGGCAGCAAGCCGTTGCAGGCGTCGCCACTGTTCGAACCGATCAAGAGTAGCAAGCAGGACCGTagggagaagaagaagaagttgaaCGTAGCGTCGTTGTTCAAGAAGCGGCACCGCGCCAGTGCTGGCGGCGGCAACGCCAGTGGCGGAGAAGCGGCCGAAGGGGAGAAGCCTACCAAGAAAGTGAAACACAAGGCAGATGCTTCACTCAATGCTGGTGCCGCTTTAGCCCCAGATACTTCTGCGGACGATATCCAGAATTGGAGGCCGTTATGGCACAAGGGCAAACCTGTCGGTACGGATGCAATGCTGGAGACAAGCGACGGTCTGAGACACACCGTCATCGTACCTGATCCGCGGCTCCCTGAAGGCTGGGCCAAACATTTGCTGCGCAGAAGTGTCAAAGGGGGCGGCGTTAAATGGGAAACGTACATTGTCAGTCCTGAAAATAGAAGATTCAGATCGAAATACGAAGTCCGCGTCTACTTGGAAGCCAATCCGACAAAAGGGGTGAATGTGAACATGTTCGACTTCTGTCTGGTCAAATCTAAGCCCAAGAAAACCAAAAAACCACCCGTTGAAATACCCGAACTGCCTCCTGCACCTCTACCTGTTTTGGAGTCGCAAGATGATTCACAGATGACAGAAGAGCAAGACTCTCAAGACGAAGACAACTCAAACAGCTTGAAGATACTGTTCGAAGACAACGCATATAAGTGTCCGATTGAAGGGTGCGGCAAGAACTTTCGCAGGGAGAACCTGGCCCAGATGCACGTGAAACATTATCACCCGGAGTACACAAAGTTCCTCGATTCCACTCCCAACGTGGCTGATCTAGCTTACGCCAGGACAGTGGGAGAGAATCTCGACAAATCTCCAGgtcCGTCAAGTAGACCACCGGGGTTGAAACCAGCTGTGAAGGCATCAACACCAAAGACGTCAAAGTTGGCCCAGTCTCCCCATCCAGAGATGCCGGATTTGAGACCGATGGGTGCTCAATCGCCTGGTATAAGCAAATGCAAGGATGCCGAAATTATAAAGTTATTGAACTCGAAACCGCCCGACAAAACCGAATCAGATTCAGCACAGggAATTCCGTCGGGTATCTCACCAGGCGGTTATCCAGATATGAGACTGAAGGACCTGTTAAACAAGTCTGAAGATGTACCGAAGAAGGACACATTCAGTAAGTCATTTGCGGTTAGTCGACCTGCTGGTATCAAGACATTGCTGCCTGTCGTGAGACAACAAGCAGTAGATCCATCTCAGAGCCAGCAGCAGCAGTCTCCTTCTGATCCCCCATCCGCGACGGGCAAACGCAAACGCGTCGCTTCCGAGATCTCCGAGCACGCCACCAGGAGCAAACAGCACCGTGCCACCACTCCACCTCCCTCCCAAACTTCCGAACAGCACCCCTCCCCAACTCCCTCCGTATCCCAACCTCCCATCCCGGTTACCGGCGATTCTCCGCTCCCCGCCGCCCAACCTACGCCCCCTCCCACAGGAGACCTTCCCCCCTCCCAACCTGACCCTCCTAACAATATCATCATTGAAGGTGGCGAGGTGATCAAGATCGTCCGCATGAAACAGGAGGAGATAATCAACTGCACCTGCGGCTACACGGAGGAGGACGGTCTTATGATACAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCTTATTGCAACAATATCGAGAGGGAAAGTCAGGTACCGGAGAAGTACGTGTGCTACATCTGTCAGAACCCGTTCAGAGAGCGACTGTCCCGCAAATACTACCACGATCAGGACTGGCTGAAACAGGGCATACTACCAACCGGTAGTTACCACTCCAGAGACGAAGAACAGCTTCAGAAACGGTTCGAGAAGCTGAAAAAGTGCCATGATCTATCCGGCGGTTTGCAGGAACTGAAAGATTACATGCACAGCCTTGCCATCAAACTTAAGATTGCTGAAATGAAAAATCACCCGAAACTGTACCTGTGGGCCAAAATGTGGGAGAAGAATTCGCTTCCCGAAAAAGTAAAAGAGGAGTGCAACGAAACTAAGCATAAGATCGAAAACGAAGATCATCAGTATATAAAAACGAATGAAGATTcggaaaaacaagaaaaacccGACGATTCCATGCTGATGATGATCCTAAAAGCGGGGAAGGAGGTGATGCCAAAGTTGGACCTGAATTTGCTGATGGACAATAATATGAGTCAGTTGCCAATCATTCCTCAACCAGAAGCTGCTATAGATTCAACCGTGTGCAGGGACAACTTGCTTCACCACATTCGTCACCAGGAATCGCTGGTCGAAGAGAGGTTGGACGACTTCGAGAAACAGATCGACGCATTGGAGGAATGCATGGATATGGAGGTCGATATGAACTATCCTAAAATGAGACATTCTTTGCAGATGCTCGCCAGAGACCTTGAAAAGCTGAAAGAGTTCAGTCATACCACCACTATATGA
Protein Sequence
MGRKCSVESCLSDSNRPEDMGVTFHKVPMHPDVRPKWMSLCHIPDDKKTVKIIYVCSRHFLRADFCNFKGKKYMLRQGVLPSVFPWDKSRLEAIKAEATVKKEKNMDEPNADVMKGELEESTLDIKSEESTEESNQTIEDVKGEPKQEKLEDKQQPPGDQPSAINNSDLIDFTINNRIEALDFNQEWYPAKILEVDHQENEVLIHFEKFSSKYDEWVSMESSRLRPMQQTAVPETTASPVGRKVTGMTDMFEVGERCLAAWSNSQKFPATVSKVLENNTYEVLFDDGFVKTLKGHRMSKSGSKPLQASPLFEPIKSSKQDRREKKKKLNVASLFKKRHRASAGGGNASGGEAAEGEKPTKKVKHKADASLNAGAALAPDTSADDIQNWRPLWHKGKPVGTDAMLETSDGLRHTVIVPDPRLPEGWAKHLLRRSVKGGGVKWETYIVSPENRRFRSKYEVRVYLEANPTKGVNVNMFDFCLVKSKPKKTKKPPVEIPELPPAPLPVLESQDDSQMTEEQDSQDEDNSNSLKILFEDNAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGENLDKSPGPSSRPPGLKPAVKASTPKTSKLAQSPHPEMPDLRPMGAQSPGISKCKDAEIIKLLNSKPPDKTESDSAQGIPSGISPGGYPDMRLKDLLNKSEDVPKKDTFSKSFAVSRPAGIKTLLPVVRQQAVDPSQSQQQQSPSDPPSATGKRKRVASEISEHATRSKQHRATTPPPSQTSEQHPSPTPSVSQPPIPVTGDSPLPAAQPTPPPTGDLPPSQPDPPNNIIIEGGEVIKIVRMKQEEIINCTCGYTEEDGLMIQCELCLCWQHAYCNNIERESQVPEKYVCYICQNPFRERLSRKYYHDQDWLKQGILPTGSYHSRDEEQLQKRFEKLKKCHDLSGGLQELKDYMHSLAIKLKIAEMKNHPKLYLWAKMWEKNSLPEKVKEECNETKHKIENEDHQYIKTNEDSEKQEKPDDSMLMMILKAGKEVMPKLDLNLLMDNNMSQLPIIPQPEAAIDSTVCRDNLLHHIRHQESLVEERLDDFEKQIDALEECMDMEVDMNYPKMRHSLQMLARDLEKLKEFSHTTTI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00260610;
90% Identity
iTF_00249015;
80% Identity
iTF_00249015;