Cvom001310.1
Basic Information
- Insect
- Calliphora vomitoria
- Gene Symbol
- ewg
- Assembly
- GCA_942486075.2
- Location
- CALNXM020000023.1:3809929-3821146[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1.3e-108 1.3e-104 348.7 0.1 1 212 78 288 78 289 0.98 2 5 2 2.1e+04 -7.4 11.6 77 115 394 434 387 440 0.49 3 5 0.11 1.2e+03 -0.8 7.2 84 137 436 490 430 502 0.64 4 5 0.064 6.7e+02 0.0 0.8 67 133 684 752 674 765 0.74 5 5 0.03 3.2e+02 1.1 1.0 66 134 772 839 760 847 0.64
Sequence Information
- Coding Sequence
- ATGAATGTGACTACAATATCGACGGGTAGTCATGCTACCCAGGCGGCAGTTGAGAGCATAACCAATGTCAAACACCAACAACAGACCTATAAGATAGAAATGCTCGAGGACAGTTTGGCATCCGACGATGATGACGATGATTTAATTAGCAGTGATGGCAGCATGTTCGATGAAACGGAATTGACTCATATTGCAGTGCAAGATGATTTGGCCAATCAATTGGCTGCTGCCGGACCAGTGGGTGTAGCTGCTGCAGCAGCTATAGCATCGTCAAAGAAACGCAAGCGACAACATTCGTTTGAAACGAATCCATCGGTGCGCAAAAGGCAACAGAATAGATTACTGCGCAAATTGCGCGGTATAATCTATGAGTTTACCGGACGTGTGGGTAAACAGGCTGTGGTTTTGGTGGCAACACCTGGAAAACCCAATACCAGCTATAAAGTTTTTGGAGCCAAACCACTAGAGGATGTAGTGCGTAATCTTAAGAATATTGTTATGGATGAATTGGAAAATGCTTTAGCCCAACAAGCACCACCCCCACCACAAGAAGATCCCTCGTTATTTGAACTGCCACCTCTTATCATAGATGGTATACCCACACCCGTGGAAAAAATGACACAGGCCCAGTTGAGAGCTTTCATACCACTGATGCTCAAGTACTCAACTGGTAGAGGTAAACCGGGTTGGGGTCGTGAAGCCACCAGACCACCATGGTGGCCCAAAGAATTGCCCTGGGCTAATGTACGCATGGATGCCAGATCTGAAGATGATAAACAGAAGATATCCTGGACTCATGCTTTACGTAAAATAGTCATCAATTGTTATAAATATCATGGCCGCGAAGATCTCTTGCCCACATTTGCCGACGAAGAGGAAAAAGTAACCCAAATGATCTCACACGAAGAGGAAGAGGAGGAAGAAGAGGTGATTGTACAGCCTGTTAGTAATCAAGCCACTACTATACAAACAATACACACAACAAATGCACCAACAAATACTACAACTAATCAACAAGTAAATGTGGTTAAAATTAATAGTTCAGGAACTGTAATAACCACAACAAATCCACATAATCCAAATAATCCTGGACCCACCATTATACAAAGTACGAATGATCAACATATAACAACAACGGCACGTTTACCAGCGTCCACAAAGATTGAATTGTGTCCTGCGCCCATGACACAGATAACAcagcaacagcatcatcaacagcagcagcagcatcagcaacaacagcagcagcaacaacagcaacaacaacaacaacagcagcagcagcagcaacaacataatcttcaacaacagcaacataatctccaacaacaacaacaacagcagcaacagcatcaacaacagcagcagcaccaccagcaacaTCATATACAGACCACAAATGTGACTTCTCAACAGCTGGCCAATGCCCAAGTTTGCATAGAACCAATGAATTTGGGAGATGTTGATTATACCACTCAAACGGTCTTATCAACTATACAAAATGCTGACGGCACTGTTTCGCTTATACAAGTTGATCCTAATAATCCTATTATTACATTACCGGATGGTACCACAGCTCAAGTCCAGGGTGTTGCTACGCTACATCAAGGAGAAGGTGGTGCCACTATTCAAACTGTTCAAAGTCTGGGTGATGTTAATGGTCATGAAAATATGACGGTCGATTTAACAGAGGCCACAGTGGCTCAAGATGGTCAAATTTATATAACGGCCGAGGATGGTCAAGGTTATCCAGTGTCCGTTAGTAATATGATTACATTACCGGTGTCAGCATCAATGTATCAATCAATGATGGCCAATATCCAGCAAATACATACGAATAGCGATGGAACCGTGTGTATAACACCAATGCAGGTAGATGCTCATACCAATAACAATAATAATTCTAATGCAAATACCAATAATAGTAGCAATAATAGTTGTAGTAGTAATAATAGTAGTAGTAATAGCAATGTTAATAGTAATAATGATGCTGATGGCAACAGTAGCGGAAATCCCAATACAGCAGCAGCAACAACAACGCCCCAACAATATCAATGTTATTCAATAATGGCAGCAACGCCCATTGCTAACACAACAGCTCATCGGCTGTTGACAAATACAGCTTTAAATCAAACACAACAGAATTTAGTTAATAATTTAAATAGCAATATTAGTGTTAATAATCATAATAATAGTAATATTAGTCCTAATAATATACGTTGCCAAATAATAAACGCCTCTAGTTTACAACAAAATTCTAGTCAAATGAATTGCCAACAACAGCAGCAACAAAATTATCTAGCAAATGTTTTACAAAATGCAACAGCTAAAGTTTTTATAGCAAATCCGACACATTTAAATTTAACAAATGCCACTAATATTTTAAACAACAACAACAATAATAATGATGCAACAAATAACAATAACCATAATAGTAATAATAACAATAATAATAATGGTCATATAAAAATTGCCACGTCTATGCCATTGCCCATAGTTGTTGCCACCACAGCTCAACATGCACAGTCTGTTGCAGCCACTGGTGCTGGGGCAAATTGTAACATTGTTAGTGGAGCTAATTGTAGTAATAGAAAATCAGGACACAAACGTCGTAAGCAAACCTTTGCCAAAGTTATACCAATTAAAATAGAGGAAAATCTTTCGACAGATGCTGCCACTAGCAACAACAGCATCAATCATAATAACAATAATGCTAGCGATAGCCTTTTAAATATACAAATTGTCAATACTACAGATAATAGTGTTGTTGTTACGGGAGGGGGTGGCTTAAGTGTTGGTGGTGTCGTGGGTAGTTTAGGCAATTTAAGAGTTGGCAATCGTCTTGTCAGTGTAGATGTTACCTCACCATCTACCAACTCTGGGTCACAGTTACCCACCAAAGCCATTAAACTAGAAGCACTCGACAATTAA
- Protein Sequence
- MNVTTISTGSHATQAAVESITNVKHQQQTYKIEMLEDSLASDDDDDDLISSDGSMFDETELTHIAVQDDLANQLAAAGPVGVAAAAAIASSKKRKRQHSFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVVRNLKNIVMDELENALAQQAPPPPQEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGREATRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADEEEKVTQMISHEEEEEEEEVIVQPVSNQATTIQTIHTTNAPTNTTTNQQVNVVKINSSGTVITTTNPHNPNNPGPTIIQSTNDQHITTTARLPASTKIELCPAPMTQITQQQHHQQQQQHQQQQQQQQQQQQQQQQQQQQQHNLQQQQHNLQQQQQQQQQHQQQQQHHQQHHIQTTNVTSQQLANAQVCIEPMNLGDVDYTTQTVLSTIQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLGDVNGHENMTVDLTEATVAQDGQIYITAEDGQGYPVSVSNMITLPVSASMYQSMMANIQQIHTNSDGTVCITPMQVDAHTNNNNNSNANTNNSSNNSCSSNNSSSNSNVNSNNDADGNSSGNPNTAAATTTPQQYQCYSIMAATPIANTTAHRLLTNTALNQTQQNLVNNLNSNISVNNHNNSNISPNNIRCQIINASSLQQNSSQMNCQQQQQQNYLANVLQNATAKVFIANPTHLNLTNATNILNNNNNNNDATNNNNHNSNNNNNNNGHIKIATSMPLPIVVATTAQHAQSVAATGAGANCNIVSGANCSNRKSGHKRRKQTFAKVIPIKIEENLSTDAATSNNSINHNNNNASDSLLNIQIVNTTDNSVVVTGGGGLSVGGVVGSLGNLRVGNRLVSVDVTSPSTNSGSQLPTKAIKLEALDN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01074177; iTF_00921187; iTF_01235460; iTF_01176680; iTF_01397066; iTF_00975342; iTF_00199600; iTF_01258964; iTF_01376374; iTF_01173911; iTF_01201335; iTF_00900280; iTF_00349915; iTF_00899262; iTF_01260735; iTF_00435264;
- 90% Identity
- -
- 80% Identity
- -