Nfer012020.1
Basic Information
- Insect
- Nowickia ferox
- Gene Symbol
- ewg
- Assembly
- GCA_936446695.1
- Location
- CAKZFO010000086.1:17384000-17399729[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1.9e-108 2.3e-104 348.7 0.1 1 212 78 288 78 289 0.98 2 5 3 3.7e+04 -12.7 17.8 77 115 396 434 386 456 0.48 3 5 0.12 1.5e+03 -0.3 7.9 85 137 454 506 447 519 0.78 4 5 0.12 1.5e+03 -0.3 0.9 58 149 709 802 704 808 0.81 5 5 0.026 3.2e+02 1.9 0.8 66 141 848 927 838 936 0.60
Sequence Information
- Coding Sequence
- ATGAATGTGACCACTATATCGACGGGTACACATGCTACCCAGGCAGCAGTCGACAGTATAACAAATATCAAACACCAACAGACGACCTACAAAATAGAAATGCTCGAGGACAGCCTGGCCTCTGACGATGATGACGACGATTTGATTAGCAGCGATGGTAGCATGTTCGATGAAACCGAGCTGACTCAGATTGCTGTGCAAGATGACTTGGCCAATCAATTGGCTGCTGCTGGACCAGTGGGTGTAGCTGCAGCTGCAGCTATAGCATCGTCGAAAAAACGCAAACGGCAACATTCTTTCGAAACGAATCCATCGGTGCGCAAAAGGCAACAGAATCGATTACTGCGTAAATTACGTGGCATAATCTACGAGTTTACCGGTCGAGTGGGCAAACAGGCGGTAGTGTTGGTAGCAACACCCGGCAAACCCAATACAAGTTACAAGGTTTTTGGTGCCAAACCTTTAGAGGATGTAGTACGTAATCTTAAGAATATTGTCATGGATGAACTGGAAAATGCTTTAGCCCAACAAGCGCCACCCCCACCTCAAGAGGATCCCTCATTATTCGAACTGCCACCATTAATTATTGATGGTATACCAACACCTGTAGAGAAAATGACACAAGCCCAGCTAAGAGCCTTTATACCTCTTATGCTTAAGTATTCAACCGGTCGAGGTAAACCGGGATGGGGACGCGAGGCAACTAGACCTCCTTGGTGGCCAAAAGAATTGCCTTGGGCTAATGTACGTATGGACGCCAGGTCTGAAGATGACAAACAGAAgATTTCCTGGACCCATGCTTTGCGAAAAATTGTCAttaattgttataaatatcatGGACGCGAGGATCTCTTGCCCACGTTTGCCGACGAAGACGACAAAGTAACTCAATTGATCTCACACGAAGAGGAAGAGGAGGAAGAAGAAGAGGTGATTGTACAACCTATCAACAATCAAGCTACTACTATACAAACAATACATACAACCAACCATGCACCAACAAATAATGCGGCTAACCAACAAGTAAATGTGGTTAAAATTAACAGTTCTGGCACTGTTATAACCACAACAAATCCACATAATCCAAATAATCCTGGACCCACCATTATACAAAGTACGAATGATCAACATATAACTACAACGGCAAGATTGCCAGCGTCGACAAAGATTGAATTGTGTCCTGCGCCGATAGCTCAGATAACACAGCAACAGcatcatcatcaacagcagcagcagcagcagcaacaacagcagcagcagcaacaacaacagcagcagcagcaacagcaacagcagcagcagcagcaacaacaacagcagcaacatcatcaacaacagcagcagcagcagcaacaacaacaacaacaacagcatcaacaacagcagcagcagcagcaacagtcGCATCAaccacaacagcaacaacatcatcaaataCAAACGACAAATGTAACGACACAACAACTGGCCAATGCACAAGTTTGCATAGAACCCATGACTTTGGGAGATGTTGATTATACCACTCAAACGGTTTTGTCAACCATACAAAATGCCGATGGCACCGTTTCACTTATACAAGTTGATCCTAATAATCCTATTATAACTTTACCAGATGGTACAACGGCTCAAGTGCAGGGTGTTGCAACGCTTCATCAAGGAGAAGGTGGTGCGACCATTCAAACTGTACAGAGTCTGGGTGACGTTAATGGCCATGAAAATATGACGGTGGATTTGACAGAGGCTACGGTAGCACAAGATGGTCAAATTTATATAACGGCCGAGGATGGCCAGGGTTATCCGGTGTCCGTTAGTAATATGATTACATTACCGGTATCAGCATCCATGTATCAATCAATGATGGCCAATATACagcaaatacatacaaatagtGATGGAACAGTGTGTATAACACCAATGCAGGTAGATgttcaaaacaacaacaacaataataataataatcataataataatagttcTAATgccaatgcaaatgcaaataatAGTAGTAgtaataatagtaatagtaataatgATGATGGCAATAGCAATGGAAATAGTAataccacaacaacaacaacagctacaGCAGCAACTGCAGCGTCCCCACATTTTCAATGTTATTCAATAATGACAGCAACGCCCTTTGCCTCCACAACAGCTCATCGGCTATTGACAACTACAGCTTTaaatcaaacacaaaatttagtgaataattcaaatttaaatagcAACAATAGCAGTAgttgcaataataataataacaacactAGTTGTAATAGTAGTAATAATATACGTTGCCAAATTATAAACGCCTCTGGTTTACAACAAAGTTCTAGTCAAATGAATTgccaacaacagcagcaacaaaactATTTAgcaaatgttttacaaaatgcAACAACTAAGGTTTTCATAGCAAATCCAGCACATTTAAATCTAGCGGCAGCCgctaatatttttaacaacaacagtACCACtactaacaataacaataatagtaATAAGAATAGTTgtcataacaataacaataataataataataataatggccACATAAAAATTACCACCGCTATGCCATTGCCAATAGTTGTTGCTGCCACAACTCACCAACGCCAGTCAATGGCAGCGGAGAGAATTAGTGCAAGAAGTAATAGAAAATCAGGACACAAACGTCGTAAGCAAACCTTTGCCAAAGTCATACCAATAAAAGTAGAGCAAAATATTattagcagcaacaacaacaacaatacgaaCGCACGCGAAAGAGttttaaatatagaaattgTCAATGATACCAGGGATAACAGTGTTGTTGCTGCAACTAATGGGGGTTGCACTGCAATGTCGACTTCTGGCTCTCAAATGCCGGCCAAAACGATTAAACTCGAGGCGGCGGACAACTAA
- Protein Sequence
- MNVTTISTGTHATQAAVDSITNIKHQQTTYKIEMLEDSLASDDDDDDLISSDGSMFDETELTQIAVQDDLANQLAAAGPVGVAAAAAIASSKKRKRQHSFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVVRNLKNIVMDELENALAQQAPPPPQEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGREATRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADEDDKVTQLISHEEEEEEEEEVIVQPINNQATTIQTIHTTNHAPTNNAANQQVNVVKINSSGTVITTTNPHNPNNPGPTIIQSTNDQHITTTARLPASTKIELCPAPIAQITQQQHHHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHQQQQQQQQQQQQQQHQQQQQQQQQSHQPQQQQHHQIQTTNVTTQQLANAQVCIEPMTLGDVDYTTQTVLSTIQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLGDVNGHENMTVDLTEATVAQDGQIYITAEDGQGYPVSVSNMITLPVSASMYQSMMANIQQIHTNSDGTVCITPMQVDVQNNNNNNNNNHNNNSSNANANANNSSSNNSNSNNDDGNSNGNSNTTTTTTATAATAASPHFQCYSIMTATPFASTTAHRLLTTTALNQTQNLVNNSNLNSNNSSSCNNNNNNTSCNSSNNIRCQIINASGLQQSSSQMNCQQQQQQNYLANVLQNATTKVFIANPAHLNLAAAANIFNNNSTTTNNNNNSNKNSCHNNNNNNNNNNGHIKITTAMPLPIVVAATTHQRQSMAAERISARSNRKSGHKRRKQTFAKVIPIKVEQNIISSNNNNNTNARERVLNIEIVNDTRDNSVVAATNGGCTAMSTSGSQMPAKTIKLEAADN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00259516;
- 90% Identity
- iTF_01397066;
- 80% Identity
- -