Pmel013038.1
Basic Information
- Insect
- Phyto melanocephala
- Gene Symbol
- ewg
- Assembly
- GCA_941918875.1
- Location
- CALNXE010001480.1:126762-138587[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 1.3e-108 1.8e-104 348.7 0.1 1 212 78 288 78 289 0.98 2 3 2 2.8e+04 -8.8 15.6 89 135 430 476 385 490 0.68 3 3 0.12 1.7e+03 -0.9 0.5 67 111 766 810 760 868 0.65
Sequence Information
- Coding Sequence
- ATGAATGTCACTACTATATCGACGGGTAATCATGCTACCCAGGCCGCTGTCGAGAGCATTACGAATGTCAAACATCAACAACAGACCTATAAAATTGAAATGCTTGAGGACAGTTTGGCATCCGACGATGAGGACGATGATTTAATTAGCAGCGATGGCAGCATATTTGATGAAACTGAATTGACACAAATTGCAGTGCAAGATGATTTGGCTAATCAATTGGCGGCTGCCGGACCTGTAGGTGTAGCTGCTGCAGCAGCAATAGCATCATCGAAAAAACGCAAACGACAACATTCGTTTGAAACGAATCCGTCGGTGCGTAAAAGACAACAGAATAGATTATTGCGCAAGTTGCGCGGCATAATTTATGAGTTCACGGGACGTGTGGGTAAACAAGCAGTGGTGTTAGTGGCAACACCCGGTAAACCGAATACAAGTTATAAGGTTTTTGGTGCCAAACCCCTAGAGGATGTAGTACGTAATCTTAAGAATATTGTAATGGATGAGTTGGAAAATGCTTTAGCCCAACAAGCACCACCGCCACCACAAGAGGATCCTTCATTATTTGAACTGCCTCCGTTAATTATCGATGGTATACCCACACCTGTGGAGAAAATGACTCAGGCCCAGTTAAGAGCTTTCATACCACTTATGCTAAAATACTCGACTGGACGAGGTAAACCCGGTTGGGGACGTGAGGCGACTCGGCCACCTTGGTGGCCCAAAGAATTGCCCTGGGCTAATGTACGCATGGATGCCAGATCTGAAGATGACAAACAAAAGATTTCGTGGACTCATGCTTTACGTAAAATTGTCATCAATTGCTATAAGTATCATGGTCGCGAAGATCTCTTGCCCACATTTGCCGACGAAGAGGAGAAAGTTACCCAAATGATCTCACATGAAGATGAGGATGAGGAAGAAGAAGTGATGCAGATTCAACCTGTTAGTAATCAAGCCACCACTATACAAACGATACACACAACTAATGCTCCAACAAATGCTACAACTAATGTAAGGCAACAAGTAAATGTCGTTAAAATAAATAGTTCAGGCACTGTCATAACCACAACAAATCCACATAATCCAAATAATCCTGGACCCACCATTATACAAAGTACGAATGATCAACATATAAcaacaacggctcgcttgccggcatcaacaaagattgaattgtgtccagcaccaatcgcacagataacacagcaacaacatcatcaacagcagcagcaacaacagcagcagcaacaacagcagcagcagcaacagcagcagcaacatcatcaacagcaacaacaacagcatcatcagcaacaacatcatcaacagcagcaacaacaccatcaaatacaaactacaaatgtaacttctcaacaactggcCAATGCTCAAGTTTGCATTGAACCAATGACTTTGGGAGATGTCGATTACACAACTCAAACGGTCTTATCAACTATACAAAATGCCGATGGCACTGTTTCGCTTATTCAAGTTGATCCTAATAATCCTATAATTACATTACCGGATGGTACCACTGCTCAAGTCCAGGGTGTTGCAACGTTGCATCAGGGTGAAGGTGGTGCCACCATACAAACAGTGCAAAGTTTGGGTGATGTTAATGGTCACGAAAATATGACGGTCGATTTGACAGAGGCATCAGTAGCACAAGATGGTCAGATTTATATAACGGCTGAGGATGGTCAAGGTTATCCAGTGTCCGTTAGTAATATGATTACATTACCGGTATCAGCGTCAATGTATCAATCAATGATGGCCAATATCCAACAAATACATACAAATAGCGATGGAACAGTGTGTATAACACCAATGCAGGTAGATGCTCATACAAATAATAATAATAATTCAAattcaaatacaaataatagtagcagtaatagttgtagtagtagtagtattagtaatagtaacaaaagcaacagcaataataatgataatggcagtagcagcaacagaaatgcagcaacaactacaagaacgcctacacaatatcaatgttattcaataatggcagcaacgcccattgctaacgcaacagctcaacgattgctgacaaattcagctttAAATCAAACCCAAAATATAGTTAATAGTTTAAATTTAAATAGCAATGCTAGTGGTAATAATAGTAATAATAATATTAGCTCTAATAGTATACGTTGCCAAATAATAAACGCCTCTAGTTTACAACAAAATTCTAGTCAAATGAATTGCCAACACCAACAACAACAACAGCAGCAGCAACAACAAAATTATTTAGCAAATGTTTTACAAAATGCAACAGCTAAAGTTTTCATAGCAAATCCGACACATTTAAATCTAACCACCGCCACTAATATTTTAAACAACAACAACAATAATGATGCAACAACTAACAATAATAACAATAATAATAATAATAATAATAATAATAATAATCATAATAATGGTCACATAAAATTTGCTACAGCCATGCCGTTGCCAATAGTAGTTGCTACCACAACTCAGAATCCCCAGTCTCTAGCAGTCACAGCTGCTGAGGAAAATTCTAGCAGTGCAACTAATAGAAAAAGTGGCAGTGGTGCTGTTAGCAATAGAAAATCAGGACACAAACGTCGTAAGCAAACATTTCCCAAAGATATACCAATTAAAATAGAGGAGAAACGTACTGCAGATGTTATTAACGCCAACACTAGTAAAAACAACTCGGGCGAAAGCCTTTTGAATATACAAATTGTCAATACTGCAGACAATAGTGTTGTTGTTGCAGGTGGTGCTGGTGGTGGCACGTTAAGTGTCGGTAGTGTCGTAGGTAGTTTAGGCAATTTACGAGTTGGCAATCGTCTTGTCAGTGTAGACGTAAGCTCCTCTTCCAACAACAACCCTGGGTCTCAGTTACCCACAAAAGCCATTAAAATAGAAACAGTCGACAATTAA
- Protein Sequence
- MNVTTISTGNHATQAAVESITNVKHQQQTYKIEMLEDSLASDDEDDDLISSDGSIFDETELTQIAVQDDLANQLAAAGPVGVAAAAAIASSKKRKRQHSFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVVRNLKNIVMDELENALAQQAPPPPQEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGREATRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADEEEKVTQMISHEDEDEEEEVMQIQPVSNQATTIQTIHTTNAPTNATTNVRQQVNVVKINSSGTVITTTNPHNPNNPGPTIIQSTNDQHITTTARLPASTKIELCPAPIAQITQQQHHQQQQQQQQQQQQQQQQQQQQHHQQQQQQHHQQQHHQQQQQHHQIQTTNVTSQQLANAQVCIEPMTLGDVDYTTQTVLSTIQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLGDVNGHENMTVDLTEASVAQDGQIYITAEDGQGYPVSVSNMITLPVSASMYQSMMANIQQIHTNSDGTVCITPMQVDAHTNNNNNSNSNTNNSSSNSCSSSSISNSNKSNSNNNDNGSSSNRNAATTTRTPTQYQCYSIMAATPIANATAQRLLTNSALNQTQNIVNSLNLNSNASGNNSNNNISSNSIRCQIINASSLQQNSSQMNCQHQQQQQQQQQQNYLANVLQNATAKVFIANPTHLNLTTATNILNNNNNNDATTNNNNNNNNNNNNNNNHNNGHIKFATAMPLPIVVATTTQNPQSLAVTAAEENSSSATNRKSGSGAVSNRKSGHKRRKQTFPKDIPIKIEEKRTADVINANTSKNNSGESLLNIQIVNTADNSVVVAGGAGGGTLSVGSVVGSLGNLRVGNRLVSVDVSSSSNNNPGSQLPTKAIKIETVDN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00259516;
- 90% Identity
- -
- 80% Identity
- -