Cvic021598.1
Basic Information
- Insect
- Calliphora vicina
- Gene Symbol
- Runx1
- Assembly
- GCA_958450345.1
- Location
- OY288235.1:19109288-19127268[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4 3.6e+04 -7.8 7.7 52 74 15 37 6 50 0.71 2 2 5.8e-74 5.2e-70 234.0 0.0 3 129 85 211 83 211 0.98
Sequence Information
- Coding Sequence
- ATGCATCtcacaaccacaacaacaaatGGCACGGCCAATACCAACAATACGGCCACAgccaataataacaacaacaatagccagaacaataacaacaacagttCGTCAAATACAAatgccaacaacaacaattcatcaaatggcaacaacaacaacagcacagAACAAAATACTCCGCCCACAGCAGCACAACTACTCAATGAGGCCTACACCAAAATGACTTCGGACATTTTGGCCGAACGCACACTCGGTGATTTTCTCACCGAACATCCGGGCGAACTGATACGCACCAGTAGTCCGCTGTTCGTTTGCACCGTATTGCCGCCACACTGGCGTTCGAATAAAACGCTGCCGGTGGCATTTAAGGTTGTCTCATTGGGCGACATCATGGACGGTACAATGGTGACGGTGCGAGCGGGCAACGATGAGAACTATTGTGCTGAGTTGAGAAATTCGACGGCAGTGATGAAGAATCAAGTGGCGAAATTCAACGATTTACGTTTTGTGGGACGCAGTGGTAGAGGGAAAAGCTTTACATTGACAATCACAGTTTCAACAAATCCGCCCCACATTGCCACCTACAACAAAGCCATCAAAGTAACCGTCGATGGACCCCGTGAACCACGCTCCAAAACCAGTAAGTAG
- Protein Sequence
- MHLTTTTTNGTANTNNTATANNNNNNSQNNNNNSSSNTNANNNNSSNGNNNNSTEQNTPPTAAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNSTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTSK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01376410;
- 90% Identity
- iTF_01373834; iTF_01260769; iTF_01312811; iTF_00331321; iTF_01173945; iTF_01194151; iTF_01236432; iTF_00716408; iTF_01137754; iTF_01376410; iTF_00370750; iTF_01165312; iTF_01374750;
- 80% Identity
- -