Preg031117.1
Basic Information
- Insect
- Phormia regina
- Gene Symbol
- Runx1
- Assembly
- GCA_001735585.1
- Location
- MINJ01173588.1:216-758[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 5 3.7e+04 -7.0 6.7 54 73 17 36 5 47 0.55 2 3 1.1 7.9e+03 -2.6 0.2 57 67 48 58 40 66 0.75 3 3 1.3e-52 9.3e-49 165.3 0.0 3 94 87 178 85 179 0.98
Sequence Information
- Coding Sequence
- ATGCATCTCACCACCACAACAACAAATGGCACGGCCAATACCAACAATACGGCCGCAgccaataataacaacaataacaatagccaaaataataacaacaacagttcATCGAATAACAATtccaacaacaataattcaacaaatggcaacaacaacaacagcagcaccGAACAAAATACACCGCCCACAGCAGCACAATTACTCAATGAGGCCTATACCAAAATGACTTCAGACATTTTGGCTGAACGCACACTGGGCGATTTTCTTACCGAACATCCAGGCGAACTAATACGTACCAGTAGTCCGCTATTTGTTTGTACAGTATTACCGCCACATTGGCGTTCGAATAAAACGTTACCGGTGGCATTTAAAGTTGTCTCATTGGGCGATATAATGGATGGTACAATGGTGACGGTACGAGCGGgtaatgatgaaaattattgtgCTGAACTGAGAAATTCAACGGCGGTAATGAAAAATCAAGTGgctaaatttaatgatttacgTTTTGTGGGACGCAGTGGTAGAGGTAAGTGTgagtga
- Protein Sequence
- MHLTTTTTNGTANTNNTAAANNNNNNNSQNNNNNSSSNNNSNNNNSTNGNNNNSSTEQNTPPTAAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNSTAVMKNQVAKFNDLRFVGRSGRGKCE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01376410;
- 90% Identity
- iTF_00258641;
- 80% Identity
- -