Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.13 2.4e+02 1.8 0.1 22 44 41 63 38 68 0.81

2 7 0.87 1.6e+03 -0.8 0.0 22 46 124 148 103 153 0.73

3 7 0.045 81 3.3 0.0 23 46 151 174 144 180 0.83

4 7 0.014 25 4.9 0.0 21 52 177 208 166 209 0.82

5 7 0.0016 2.9 7.9 0.1 21 46 205 230 201 232 0.91

6 7 0.00017 0.3 11.1 0.0 20 51 232 263 229 264 0.89

7 7 0.00019 0.35 10.9 0.1 21 46 261 286 259 289 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.13	2.4e+02	1.8	0.1	22	44	41	63	38	68	0.81
2	7	0.87	1.6e+03	-0.8	0.0	22	46	124	148	103	153	0.73
3	7	0.045	81	3.3	0.0	23	46	151	174	144	180	0.83
4	7	0.014	25	4.9	0.0	21	52	177	208	166	209	0.82
5	7	0.0016	2.9	7.9	0.1	21	46	205	230	201	232	0.91
6	7	0.00017	0.3	11.1	0.0	20	51	232	263	229	264	0.89
7	7	0.00019	0.35	10.9	0.1	21	46	261	286	259	289	0.92

Coding Sequence: ATGGTTTTGGATATAGAAAAAGGAATTCACTCATCCAATCGGAATGAGCATGTTGATGATGAGGAGAAAAATAGTGGTGATGATGGCATAACAACATACGTGGAGAATCTTCCACCGGATGAACAGCAATACAGGTGTTACATTTGCAAGCAATCATTTTGGCTGAAACGCGATCTATTCAGGCACAAGCACATGAATACTCGTTGCAACAGAGATGTTTCACCTGTGCATGAAATATCACCACATCGGAAAAAACCGAACGCAGAGGAGTCTGGAAGTACAGCGCGAACGAAAAAGGTGGGCGATTCAAAGCGGGATAAGCAAGATGACGGAAAGGATTGTACTCATCTCGTAAAAAGCAGCACCGCTTCATCAAAGAGCTCCTGTTCGGAGTATTACACAGAATTCAGGGACAAGAGCAATTTGACCAAGCAATTAAGGATCCAAATGAAGCCGTATGAGTGCGGGGTTTGTAAGAAGATTTTCAGGTACTCTAGCGGTTTGACCAACCATCGTACAATTCATACTGGTAAAAAGCCGTTCGAGTGCGGAGTTTGTAAAAAAACATTCAGTCGTCGTAACGATTTGACTCGCCATCTTCGGATTCATACTGGTGAAAAGCCGTACGAGTGCAAACATTGTATGAAAGCTTTCAGTCAATCCAGCACTTTGACCCGCCATCTTGGGATGCATAATAGTGAAAAGCCGTTCGTGTGCGGGGTTTGTGACAAAGCTTTCAGCCAACGGGGCGATTTGACTCGCCATCTCAAGATTCATACTGGTGAAAAACCATTTGCATGCGACATttgcaaaaaaacatttcgacaAAAGGTGCACATACGTCAACACATGAATGTTCACATTCCCAACGgtaaaaaaaaattacaagtGCAAAAAAGTGTTCCACCAACGACACATTCTGTCCGAGCATCGTAA
Protein Sequence: MVLDIEKGIHSSNRNEHVDDEEKNSGDDGITTYVENLPPDEQQYRCYICKQSFWLKRDLFRHKHMNTRCNRDVSPVHEISPHRKKPNAEESGSTARTKKVGDSKRDKQDDGKDCTHLVKSSTASSKSSCSEYYTEFRDKSNLTKQLRIQMKPYECGVCKKIFRYSSGLTNHRTIHTGKKPFECGVCKKTFSRRNDLTRHLRIHTGEKPYECKHCMKAFSQSSTLTRHLGMHNSEKPFVCGVCDKAFSQRGDLTRHLKIHTGEKPFACDICKKTFRQKVHIRQHMNVHIPNGKKKLQVQKSVPPTTHSVRAS

Sequence clustering based on sequence similarity using MMseqs2