Basic Information

Gene Symbol
Aef1
Assembly
GCA_945910015.1
Location
CAMDTZ010000260.1:607793-608572[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.001 24 7.1 0.4 20 48 130 158 117 162 0.78
2 4 1.9e-05 0.44 12.6 0.0 21 50 159 188 155 190 0.87
3 4 0.0049 1.2e+02 4.9 0.1 21 51 187 217 185 218 0.87
4 4 0.00013 3 9.9 0.1 21 47 215 241 213 246 0.89

Sequence Information

Coding Sequence
ATGCAGCGGCTGTTGCCTCACAAATTAAACGAAACGTGCACTACTTCTTCTATCTCTCAGTCAAAATCTGAACCCGAACACCACACTCCAAGCGAACACACACACACTGAAAATTGCTCCCCTCGCCATCTTTCCTACACAATGACTAATTGTGAAATCGTTATTGTTGCCACAACCGATGAACCAGCCACAGATTTGCAAATACCCTTTAACGTGATAACCTCAGCGGCAACAGTATCAGCGGCTGGTCCCACTACTACGACACATCACCTCGCTCCATTGCAACAACAGCATACCGAACAGCAGCAGCTGCTGCAGCCAGAAAGTATCCAACAACAAGTGCAAACAGGAGCACTACCGCCACATTTGGACCGTCCGCCGACAAACGGTCCCGAGAAGCCATTCCAATGCAATATATGTGAGCGAAGATTTCGACAGCTCAGCACACTAACGAATCACGTAAAAATTCATACCGGCGAGAAACCCTACAAATGCACGATCTGCGACAAAACCTTCCGACAATCGAGCACCCTTACGAACCATATGAAAATCCATACCGGCGAGAAACCCTTCATCTGCTCATACTGTCCCAAGCAGTTCCGCCAGCTGAGCACGCTAACGAATCACCTGAAAATCCATACCGGGGAGAAGCCGTTCGAATGTGCCGTTTGCAAAAAACAATTCCGCCAATCGAGTACGCTCAACAATCACATAAAGATCCACGTCATGGACAAGGTATACATACCAGTAAAAATCAAAACCGAGGAGGACGAAGGATGA
Protein Sequence
MQRLLPHKLNETCTTSSISQSKSEPEHHTPSEHTHTENCSPRHLSYTMTNCEIVIVATTDEPATDLQIPFNVITSAATVSAAGPTTTTHHLAPLQQQHTEQQQLLQPESIQQQVQTGALPPHLDRPPTNGPEKPFQCNICERRFRQLSTLTNHVKIHTGEKPYKCTICDKTFRQSSTLTNHMKIHTGEKPFICSYCPKQFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVMDKVYIPVKIKTEEDEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01223723;
90% Identity
iTF_00672533;
80% Identity
iTF_00241707;