Basic Information

Gene Symbol
MBD3
Assembly
GCA_035578155.1
Location
JAPWDM010000002.1:50195255-50198600[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.3e-26 6.7e-22 78.3 0.1 2 72 7 72 6 75 0.94
2 2 0.0014 11 7.1 0.1 29 74 96 149 80 152 0.84

Sequence Information

Coding Sequence
ATGGCTAGTATAACAATTGAGaagaaaaaatatgattgcAATTCTTTGCCAAAAGGATGGCAAAGAGAAGAGGTGTTGAGAAAAACGGGATTATCAGCCGGAAAAGTAGATGTATATTATTACAgTCCAAATGGGCAAAAGTTTCGCAGCAAACCACAGTTGGCACGTTATTTTGGTGATTCCATTGATCTGGCTATGTTTGATTTCCACACTGGCAAATTCAACTCTCTGCTCTTGCGCAAAAACAAGCTGCAGAGGGGTACCCAATTTGATTACAGtaGAGGTGTAAGAAACGATGCCTCCTTAGTACCTCCAATTAGGCAAACCGCTTCAATTTTTAAACAACCAGTTACTGTTTATAAGACACAAGAAGGTAAAGTGAAAACAGATTTTAAACATGGGCCACAAGAAAAACCAAAACAACTGTTTTGGGAGAAACGTTTAGAGGGATTGCGTGCATGCGACTTAGATGGAATCGAGTTCGACGCTATGGAACTTCCTAAAGGTTTGAAACCGgTTGGACCACATGTTAGTGAAGAGACGATAATTCAATCATTAGCGACAGCGCTGCATGTTTCAACACAACCAGTCACTGGCCAAACAGCTCCAAAATCAGTATTAGAAAAGAATCCGGGCGTTTTTTTAAACCCGGAACAACCACTAGTTCAAGCGGTACAAATCGGTGAAGAGGACATTCGTCGTCAAGAAGAACGTGTTCAACTTGCTCGAAAACGATTACAAGAAGCTCTCCgaagttaa
Protein Sequence
MASITIEKKKYDCNSLPKGWQREEVLRKTGLSAGKVDVYYYSPNGQKFRSKPQLARYFGDSIDLAMFDFHTGKFNSLLLRKNKLQRGTQFDYSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKTDFKHGPQEKPKQLFWEKRLEGLRACDLDGIEFDAMELPKGLKPVGPHVSEETIIQSLATALHVSTQPVTGQTAPKSVLEKNPGVFLNPEQPLVQAVQIGEEDIRRQEERVQLARKRLQEALRS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01343982;
90% Identity
iTF_00332360; iTF_01060635;
80% Identity
-