Basic Information

Gene Symbol
Zfa
Assembly
GCA_937001565.2
Location
CAKZJP020000635.1:888333-897029[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.011 1.6 10.9 1.6 3 23 649 670 648 670 0.96
2 23 0.25 36 6.7 0.3 1 22 1054 1075 1054 1075 0.95
3 23 9 1.3e+03 1.8 0.4 1 22 1117 1138 1117 1140 0.82
4 23 0.02 2.8 10.1 4.8 2 22 1150 1170 1149 1170 0.93
5 23 2.6 3.7e+02 3.5 0.1 3 23 1179 1200 1177 1200 0.89
6 23 0.021 3 10.0 0.2 3 23 1221 1242 1219 1242 0.96
7 23 0.004 0.56 12.3 2.5 1 23 1248 1271 1248 1271 0.95
8 23 0.15 21 7.4 0.0 1 23 1297 1320 1297 1320 0.90
9 23 0.023 3.2 9.9 3.4 1 23 1325 1347 1325 1347 0.97
10 23 0.01 1.5 11.0 0.2 1 23 1353 1376 1353 1376 0.95
11 23 0.0048 0.69 12.1 0.8 1 23 1389 1411 1389 1411 0.97
12 23 0.00021 0.03 16.3 1.8 1 23 1461 1484 1461 1484 0.97
13 23 0.0032 0.45 12.6 0.9 1 23 1544 1567 1544 1567 0.95
14 23 0.0029 0.41 12.8 2.1 2 23 1594 1616 1593 1616 0.95
15 23 0.048 6.7 8.9 0.1 2 23 1622 1644 1621 1644 0.94
16 23 0.0021 0.3 13.2 0.4 1 23 1688 1711 1688 1711 0.97
17 23 0.00051 0.072 15.1 1.0 1 23 1719 1741 1719 1741 0.93
18 23 0.00013 0.019 16.9 0.3 2 23 1834 1856 1834 1856 0.93
19 23 2.7e-07 3.8e-05 25.4 1.4 3 23 1863 1883 1862 1883 0.98
20 23 0.027 3.8 9.7 0.3 1 23 1901 1923 1901 1924 0.95
21 23 0.22 32 6.8 0.0 1 23 1947 1969 1947 1969 0.97
22 23 0.033 4.7 9.4 0.6 1 23 1975 1998 1975 1998 0.95
23 23 0.00031 0.044 15.8 0.4 1 23 2006 2029 2006 2029 0.96

Sequence Information

Coding Sequence
ATGAATGTAAACTATGATCGTGTTTGTAGACTGTGCTTGTCATCTCGAGGCGAATTACTGCCGATTTTTCCTACCACCAGTTCGGATGACTCGGAACCTCCCGTCCTCGCTTTGAAAATCAAGGATTGTGTGTCCGTACAGATAAACGAAAATGACGACCTGCCCACTAATGTCTGCAGGAAATGCATAGAAAATGTCAATAACTGGCatgtttttaaaaatgtatgtgaaaGGACACAAAACAAACTACAGTCTCTAAAAGATGGCAGCCAACTAGAAGAGgtgaaaataaaaagtgaacCACTATCTGATGGGGCTTATGATGATGGAGTGGTCATTGATGGCTCATATCCTGTCATTGAGAATGCTCAGAATGCTGGCTATTCAAACAAAGTGCAACCTGAAGGTCCCCCAATCTTGGCTTCGTTGGGGCTCACACCAAGAAGTGATAAGAAATGTGTGGACCCGCGAATGGATTGGCATCGGGTCCATGCAATTTTGGACATGGTTCAAGACAATGAGGTGATTGACTCTCTGCAGGCAAAGGAAGAGTGCGATGTTTTACAGCATTCTGATCATGACTCAGACACAGAAGCCGAACTCCAACCAGAAATTGATGATGATTATGTTGATTGCAAAAGTGGTTACatatgcaaaaataaaaaagttatatcaAAAGTTCCAAAACTATCAACTTCTGTAAATAATGCCAGAGTCAAAGAAGCTTTCAAACTTAGGAAACGTAAATCAGAAGTTCGTAAACATTGTTCACAACCAAAAAATGCGTGGCAGTTGTTATTCACCGATGACCTACTAGAATTGATTGTTTCTTCTACTAATGACAATATTGTGACAAATGGGAAAAGTATCACAGAGTCAACTAGTGTCAGCGAAATTAAAACGCTTATCGGTATTCTGTATCTGCACGGCATAATGCGGCCGACGCATCAGAAAAGTGGTGACCTTTGGAACAGTGAATGTGGTGTTCCTTGCATCAGAAATGTCATGAAATACGAAAGGTTTAAATTCCTGCTTCAAAACATGAGCTTCGATAAAGAATACGACGACAGCATTATACAGTTCGACATAATGAAGCGTATGCGTAAAGTATTCGAAATCTTCGCCATGAATTGCAGAACATCTCACGAGATCGAGAATGTCGCGGTTATTGATGAGATCATCGTGCCAGTTTATGGACCTTGCCCATTTCGATACGATATTGATAAGAAGCCGCTGAAGCGGGGCATAAAAATGGTATTGCTAGTTGATCCATCCACATTCTATATGAGCAATTTAGACGTCATTACTGATCCTTATTTTGGCGCCGAAGAGATAACGAAAAAGTTGGTTCAGCATTTAGCTGGAACCGGCAGAGCTATTGTTATGGATAGTTGGTTCACATCTCCCTCATTGATGGATAGCCTTAGAAATGAGTACCAGTTGTATTCTATTGCAGCCTTGAACCGTAGCAGTGATATGATTCCCCCACTATTCCTATCACAATACAGGAAATGTCGAACATTCATGTCTGGATTTATTGATCATGAAGTATCACTGACATCTTATGTCAATACTGAGGGGAAATCAGTTAATGTATTGACTAATGAGCCTAGATATTACAGGAAGGGTCATATAAATCACACTACAGTTGTATCGGTGTATAAGAAGAATCAGTCGGCTGTAGAAGTTGTGGATGTTCTCATGAATTACTACACTACAATGCAACACACAAATGATTGGACACTGTCCTTATTCTTTACATTGCTGAATATTGCCTCTGGTGCAGAGAGTGAAAACAATGAAGAAGACGAGGAAGAAATGAACGAGCCCGCACAAAATTTCCCGAAAATGCCCCACATGCCTGAGGTGTCCATCACGGTGATGAGGCCTACTGGTGAAACCTTGCACGCTCGCCAAGGTATTCACCAACTCGCCTCCAAACTGTGCCTCGTCTGCGGCCGCTCCTACAGGTACTCCCACAACGCACGCAGACATGAACTTACCTCTCACAGTTTCGATagatatacaaacaaaattacTCCTAAAAAAACCCTTAATCATCTACAACCCAAACTCAGACCGAACCCATTCAACCCCAAAGCACGGATGATGCCGAATCCTATTAGTCATAAGATGCAGTTCTTTAACAAGAACATGTCAACAAAAATAATGCCCATAAACAAAGTTATAACGCCACAGAAACCCATTCCAATAAAGACGTCAAAGACACAAAATAATTTGCCTTATCCTCTACGCATTAAAGCACTCAAAGAtttacaaataaagaaaaaggagcCTCAGATTCTAAAGACTTTGTTAACCGCTAAACCTGAAGTTCTGGTTTCCGAACCAGAAATTCTTAATTCTGGGCCCGAAAGTCCGGAAACATTGATATCTGAGCCTGAAATTGCGTCTTTTCAAGTCGAAGCTATTCTTACGGAACCCGATGCCGATGCATACGATGATCCACAGCAAGGCGATGAAGAAATGGATGAAGAAATGAATAACGATCAAAGTCAAAACTATGACACAGTCGAAATGGACTCTGAAAATGAAATAGAGATTGCTCGTCAGCACGGCATTGAACACGAAGGTGAGGAAAATGCTGATGAGGAAGAGAATATCGATCATGATGACGATAATAACATGGAAGGCGCTCAGAGCGATAACGAGAAAGACGGCAATGACGATACAGCCGAAAGTCAAGAGAACATGGAAGAAGATGATAGTGTTGATATTAAACCTGAAGACCAAATTAAGGACGATGAAGGCCAAGAGGAGAGAGAACACGAAGAATTAGAACTGAACCACAACGAAAACGAGGAAGAAGACGATGATGAACTTCCAATATCATTAGCGCCCGTCGTCGAAATAAGTGAGGGATTGCAAGCAGACTCGTTTAACAACGAAGTCAACGAAGACGACGAGGAACTCGATGAAACTGCCGATACCAATGAAATCATTGAAGATGAGGAGCAAGTCAAAGAACTTGATCCTGACAAAACATATGTCACGAAAACCCAAAGAGACTTCATCCAGAAGTATCGTGACATAATTCAGCAAATCAACACGAAGCGGTGTTTATGTTGCGATCGAGAACATCCTCGCAGAAAAGCTGTTATACAACACTTGCAGAAAAACGGACACAAGGTACCAAAACACACTTGTTACAACTGCGTCATCACGTTCGGACATATTGGCGCTCTACTCAGTCATATGAGGTCGAATTCTTGCACTAATTTGTGGAAGAttatttacaatgaaaatggtATTACTGACGACTTAGTTCTCGAAGATGAGCCGAAAGAGGTCAAGGTTGCATACAAAGATATTTTCAATGCCAGGTCATACGCTTGCAAGCTCTGCCCAGCTAAATTTCAACTGAAACAGTTTATTATGAAGCATGTTTTGGATACTCACGAGGATGGACAATCTAGGGTACCGCTCTGTTGTGTCCACTGCCGTTCTAGGTTCAAAGATAAGAGCTTGCTAAAGAAACATATTCGTAAAGGTGATTGTACAGTTTATATTGCTTGCGATTTGTGCTCAGAAAAGTTCGGGAACATGCAGGACTTCAACGACCACGCGCTAGGTATCCACGCTGGCAGTTTCGATCAGTCGGATAATCAAAGCAAATGTGTTGACGGTCGACCAACAGACTGTCCTTTGTGCGGAAAGAAAAACAGCAGCTATCCGAATTTAGTGAAACATTTGAAAATTATACACGCGGAGGAGAAACCTCACTACTGCCAGCATTGCGACGCTAAATACGAGCAAGCTACTGATCTGAACAAACACATTTACATGGAGCATTCTGACAGGACATTAGGCATGGCGCCCGCTGAACCGGATATGTCCTTAGTTAAGGAAGAAGCAGAGGAGTACCATTACTCCTGCACAGAATGTAATGCCATATTCGAAACTGTTGATGCGTGGACCGATCATCAAGTCGCCGAACATAACCAAGTAGCCCATCACTGTGACCAGTGTGAAAAGAAATTCCTTCGTCCTTCAGAGCTGGCAGAGCACAAGAACACACACTTGAGGGTTAAATTCTATCCTTGCAGTGTATGCCCTAACTCTTACAGCACTCCACAGAAACTGTCTGAGCATGTGCAGCAGTCACATCCAGGAATTGGCGCAGTCGCGGCAACTGAGTCGGAATTCTTCTGCGACATCTGTATCAGAGCATTCAAAAGTCGCCAAGCTTACTCTAATCATATGCGTATTCACGctaaagtacctactactaaCAGAAAGCCAGCTCCAGGTAAAGAGGGATTCGCACCACAAATTATCGGGAAACCTATCAAACAATATCCTATGGTTCAACCTGGCTTTGTGTCAtttaaacctaattacaacATCCCTAACGCTCCATATTCATGTGACATTTGTGGTAAAGGTTTCATGCACAAGAAGAATATATGGAAACACAAGAAAGTGTTGCATGCCGATATTTTAGTCGATAGACATGACAGTGAAGAGAACACCATGCAAGCTTCCACAGAAGAGGAGGAATTCAACCCTGATGAGAATGGTGCCGTTCTCTCAACGCCACAATTTGACAGTTTTAACTTTTCGAGCTTCCCGAACAATGCTCAACAAACGCCAACAGATACAATGTCGTATGCGTGTGATTTATGCAGCAAACGGTTCCCGCTTAGGACTAGTTTATGGAAACACAAGCGCGCTAAACATGGAATCGTAAACCCTAGCGCTAACAGTAGCAACGATACATCCACGCCGTCGGCTAGTGGGGAAGGCAGCAGTAGATCTAGCTGCACTATATGTAGAATCACATTTTCAGATAAAAAGTCTTATTATCGTCATCGAAAGAATGTCCACAAATCTACCGTTCAAATGTGCAAAATATGTGGCAAACCGCTAAGTTCAACTTTGGAACTATACGAGCACTTGAAAGCCGCTCATGCAAGGGAATTACTGGGTTATAACGCTAACCAAGGCTCCAGTAAATCACAAGATATTTCACAAGAGATTGAACCCGATTATGAAAATGATCAGGAGTCTGTCGACCCCAGCGTCGATTACCAAGCGCGCTACCCGTGTGATACTTGTGGCAAACAATTTGTGGGTTTGCTAGCGCTGCAAAACCACCAGTGCATCAACCACATACCATCACAACCACAGACGTTTGACTGCGAAATTTGTCACAAGAGCTACACTTCAATATCTGCGCTAAAAAGCCATCGTGGGTGGCATTTACGTTCACCCGATGGAAAAGCAGCCGCCAACAATTCAGGCCTATGGATGCCTCAGCACAAAGTTACTAGCAAGATTAGCAAACACGAGGTCATCGACCCGTCACAACTTGCTAAGGTCACACATACCCCCACTCCCCCTCCTGTCACTGCTACCGCAGCGAAAAGAAGACTACCACCAGAGGTCGAAGTGACAGTCGTAAATCCAAATAAGAAACTGCGCTCAGACGACTCTGTCGACTTGGATATGCAAAGTACTGGAGCAATTGAGGATAGGTACTGTACGATTTGTGACAAGGAATTTACAAAACGCGCGGCGTATCAGCGCCACATGGACGAGGTACATCAACCGAACTCTGTGTTCTGCCCGATCTGTGATAAGAGTTTTACAAGGAAATCCACACTGCTCATTCACATGAAGAAACACTACGAGAGCGGTGAGGGCAGTTCCTCTGCTACAGGTCAAGGGGACGATGATTACTCCTGTGATTTGTGTGGCGCTCAGTATGACAATGATCAGGCTTTGAGGGCGCACCGAGCGCGGCACCATGGAGAAGATGAAGAGTCGGCAGAAGAGAGTGATGACGGAAATGTTCCTATTGCTCCTCCCGGTGAGTTCACATGTGCGCAATGCGGTGACGGCGTGGCTACACCAAGAGACCTCATCGCCCATCGCACAATGCACGCTACTCCCACCAAATTCTTCTGTAACATATGCAAAGTGTACTTCGCTCGGGCGCTCGACCTCTCCTCGCACACTCGGGCGCGACACGCTGACAATGAAAAGGTATTCTTCCCGTGTGCCATGTGTGATAGGTTTTACATGAACAAGAAGAGTTTACAGCGGCACATCGAGATGGCTCACTGA
Protein Sequence
MNVNYDRVCRLCLSSRGELLPIFPTTSSDDSEPPVLALKIKDCVSVQINENDDLPTNVCRKCIENVNNWHVFKNVCERTQNKLQSLKDGSQLEEVKIKSEPLSDGAYDDGVVIDGSYPVIENAQNAGYSNKVQPEGPPILASLGLTPRSDKKCVDPRMDWHRVHAILDMVQDNEVIDSLQAKEECDVLQHSDHDSDTEAELQPEIDDDYVDCKSGYICKNKKVISKVPKLSTSVNNARVKEAFKLRKRKSEVRKHCSQPKNAWQLLFTDDLLELIVSSTNDNIVTNGKSITESTSVSEIKTLIGILYLHGIMRPTHQKSGDLWNSECGVPCIRNVMKYERFKFLLQNMSFDKEYDDSIIQFDIMKRMRKVFEIFAMNCRTSHEIENVAVIDEIIVPVYGPCPFRYDIDKKPLKRGIKMVLLVDPSTFYMSNLDVITDPYFGAEEITKKLVQHLAGTGRAIVMDSWFTSPSLMDSLRNEYQLYSIAALNRSSDMIPPLFLSQYRKCRTFMSGFIDHEVSLTSYVNTEGKSVNVLTNEPRYYRKGHINHTTVVSVYKKNQSAVEVVDVLMNYYTTMQHTNDWTLSLFFTLLNIASGAESENNEEDEEEMNEPAQNFPKMPHMPEVSITVMRPTGETLHARQGIHQLASKLCLVCGRSYRYSHNARRHELTSHSFDRYTNKITPKKTLNHLQPKLRPNPFNPKARMMPNPISHKMQFFNKNMSTKIMPINKVITPQKPIPIKTSKTQNNLPYPLRIKALKDLQIKKKEPQILKTLLTAKPEVLVSEPEILNSGPESPETLISEPEIASFQVEAILTEPDADAYDDPQQGDEEMDEEMNNDQSQNYDTVEMDSENEIEIARQHGIEHEGEENADEEENIDHDDDNNMEGAQSDNEKDGNDDTAESQENMEEDDSVDIKPEDQIKDDEGQEEREHEELELNHNENEEEDDDELPISLAPVVEISEGLQADSFNNEVNEDDEELDETADTNEIIEDEEQVKELDPDKTYVTKTQRDFIQKYRDIIQQINTKRCLCCDREHPRRKAVIQHLQKNGHKVPKHTCYNCVITFGHIGALLSHMRSNSCTNLWKIIYNENGITDDLVLEDEPKEVKVAYKDIFNARSYACKLCPAKFQLKQFIMKHVLDTHEDGQSRVPLCCVHCRSRFKDKSLLKKHIRKGDCTVYIACDLCSEKFGNMQDFNDHALGIHAGSFDQSDNQSKCVDGRPTDCPLCGKKNSSYPNLVKHLKIIHAEEKPHYCQHCDAKYEQATDLNKHIYMEHSDRTLGMAPAEPDMSLVKEEAEEYHYSCTECNAIFETVDAWTDHQVAEHNQVAHHCDQCEKKFLRPSELAEHKNTHLRVKFYPCSVCPNSYSTPQKLSEHVQQSHPGIGAVAATESEFFCDICIRAFKSRQAYSNHMRIHAKVPTTNRKPAPGKEGFAPQIIGKPIKQYPMVQPGFVSFKPNYNIPNAPYSCDICGKGFMHKKNIWKHKKVLHADILVDRHDSEENTMQASTEEEEFNPDENGAVLSTPQFDSFNFSSFPNNAQQTPTDTMSYACDLCSKRFPLRTSLWKHKRAKHGIVNPSANSSNDTSTPSASGEGSSRSSCTICRITFSDKKSYYRHRKNVHKSTVQMCKICGKPLSSTLELYEHLKAAHARELLGYNANQGSSKSQDISQEIEPDYENDQESVDPSVDYQARYPCDTCGKQFVGLLALQNHQCINHIPSQPQTFDCEICHKSYTSISALKSHRGWHLRSPDGKAAANNSGLWMPQHKVTSKISKHEVIDPSQLAKVTHTPTPPPVTATAAKRRLPPEVEVTVVNPNKKLRSDDSVDLDMQSTGAIEDRYCTICDKEFTKRAAYQRHMDEVHQPNSVFCPICDKSFTRKSTLLIHMKKHYESGEGSSSATGQGDDDYSCDLCGAQYDNDQALRAHRARHHGEDEESAEESDDGNVPIAPPGEFTCAQCGDGVATPRDLIAHRTMHATPTKFFCNICKVYFARALDLSSHTRARHADNEKVFFPCAMCDRFYMNKKSLQRHIEMAH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00017541;
90% Identity
iTF_00758469;
80% Identity
-