Basic Information

Gene Symbol
Rfx2
Assembly
GCA_950370525.1
Location
OX493264.1:134747741-134762763[+]

Transcription Factor Domain

TF Family
RFX
Domain
RFX domain
PFAM
PF02257
TF Group
Basic Domians group
Description
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.6 1.8e+04 -2.7 0.5 4 35 51 82 48 102 0.64
2 3 2.4 2.6e+04 -3.3 0.3 23 32 136 145 124 157 0.59
3 3 6.1e-38 6.6e-34 117.2 0.1 3 78 374 449 372 450 0.97

Sequence Information

Coding Sequence
ATGCATTCGCGACTGATTTTGGATCAACAGCAGCATTTACATCACCACTTGCAGCATTTAAATACGTCGACAAACATCAATCATATTTTGGAAAGGTGTTGTTGTAATGCTCGTGCCATAAGTGGTCATCAGAACCAACGGAATCAGCAACATCAACAGCTCCTTCAACAAACCTATCAGGCTTTTACACCACAACACCATCACCATcatcaccaccaccaccatTACCAACATCGCCAGGTGCACCTGCATCAACAGCAATCGGTGAGTCAACAGCAACAACCGCAACAGTTATCTTCACCAGTCCTGTCCGTTTTCTCATCcactcaacaacaacaacatcatcagcaacagcaTCAGCATCAGCCACAAACACAAtacgaaaataaacaaaactctaTAGCCCATCGTTTGTACCATCAATATCACCAGCAGACTGTCGTTACTACCGTATCTTCAAGTTGTTCTGCTGTAGTTGCAGCATCTCCATCATCACACTTGACGCTTTCATCTGTTCCACCTGCTCCCGCTCCTGCTTCTACTCCTGCTGCTTCATTTTCATCTTCTCCAATTTTATCACCAATTCCACCAGGTGTCTCGGCGACGGCATCAACAATGTATCGACGTCATAACAATTTATCATATTGTGGTGtttCCAACCAAGATGCAGGCCAAAACTATCAAGTCCAATACGTGGACACAGAGTTGTATCATAGCAATTCAAGTCAATCTCAAatGGCTTATCCTTTTTGTCCCATTGGAGATTATCAGGCCGGTGGACAATCTTATTATTCCACAACAACAGCTCCCAATTACTCGTCAACTATACCTTTGAATACAGCAACACATCCATCGACGTTGCCATATATAGTGCCAGTGGAAGATGGTCTGCTGTTAAACACATCTTCGCAGTCCCATAGCAGAGATTCTCCACATAGTTTAACGGAAGTTGCATTTATGCAAGAAACCCATAGTACATCCCAAACGCCTACATCTACAACTGCAAACTCCGTAAATATCGGAAGTGTTAATGTACAGGGAGGAAGTAGATCCGGCGGTGGAAATGTCTCTCCGCAACACGACCTCAATACTATAGggaacacaaacaaaatagcCTCAGCGACTattaaatgGCTGTCACGGAATTATGAAACTGCAGAAGGCGTTAGTTTGCCACGCTCAACATTGTATAATCACTACATACAACATTGCAATGAAAGCAAAATCGAACCTGTAAATGCAGCCAGTTTTGGGAAACTCATACGATCCGTATTTGCGGGACTGAGAACTCGACGTCTTGGCACTCGCGGTAATTCAAAATATCATTATTATGGAATACGAATTAAACCAGAGTCGGTGCTTAATCAAATTCCTGATGAAAAGCCAgcatttcaaatacaaattcCAAATACTGCTCACATGACTCAGAACCAAAGTCAAAATCCTATGACCCCCTGCAGTTCAAGTCCAATTGCTGGGACCTCCAGTACGCTACACTCTGGTGGCACTAACAATATGCTGCATAATAGTCGGTATTCCAAAAAAACGCATTCCTTTAAAACGGAAACACATGAAGCTTGTGGCCAAtttattgGCGATGGCGGTGGAGCAATACCATCATTTCCCACAATCGAACTGGACAACACTTTTGATAGCGAGTTAACTCAAGAAGATGTCGAAACATTTCGCTCAATGTATCGTGAGCATTGTGAGAATTTTTTGGATGCTGTCTTAAACCTAGAATTTAATACTATTGAATTTCTTTGGCGAGATTTTTGGCGTGAAAACAGCAGTATGGATGAATGTACCGAAGAGGagaaatatttaactaaagcaaaattatatttaatgtgtCATTGCACAGGGGTTCAGAAGTTCGTGCGTGAGATTGACTACCAATTTTACCAGAATATAGTAGATGTTATAATACCAGACGTCTTAAGGTCTATTCCGAATTCTTTGACGCAAGCCATACgcaattttgctaaaaatatggaaatttgGTTATGTGAATCAATGATCGGTGTTCCTGAACGCATGGTGCAAATAAAATCATCAGCAGTTTCGGCATTCTGTCAAACACTGCGCCGATATACGTCCCTCAACCATCTGGCTCAAGCAGCCAGAGCCGTTCTTCAGAATAGTGGGCAAATAACACAAATGTTGAATGACTTAAATCGCGTAGACTTTCACAACGTCCAGGAACAAGCCGCTTGGGTGTGTCAATGCGAACCGGCAATAGTGCAGCGCCTAGAAAACGACTTTAAATCTGCTTTGCAACAACAAAGTTCTTTGGAACAATGGGCTGCCTGGTTGCAGGTTGTTGTGGAATCAGCTTTACAAGATTATTGCGGAAAGCCTGGCTATGCGAAAGCTGCTCGGCAATTTCTACTTAAATGGAGCTTTTATAGTTCAATGATAATTCGAGACTTGACATTGCGGTCTGCATCGAGTTTTGGCAGTTTTCACTTAATACGATTACTCTATGATGAATATATGTTTTACTTGGTCGAACATAAAATCGCAGAAGCCCATCAGAAAACAGCTATTGCAGTCATTTGCGATCTAAAGcaCAAGGAGGTGGAATTTGATTTTGGCTACCAACTGGAATACATTGCTGCTGATAGTGTTGTAAATGAACGTGGAGCTAAACGAATGAAACATGAATGA
Protein Sequence
MHSRLILDQQQHLHHHLQHLNTSTNINHILERCCCNARAISGHQNQRNQQHQQLLQQTYQAFTPQHHHHHHHHHHYQHRQVHLHQQQSVSQQQQPQQLSSPVLSVFSSTQQQQHHQQQHQHQPQTQYENKQNSIAHRLYHQYHQQTVVTTVSSSCSAVVAASPSSHLTLSSVPPAPAPASTPAASFSSSPILSPIPPGVSATASTMYRRHNNLSYCGVSNQDAGQNYQVQYVDTELYHSNSSQSQMAYPFCPIGDYQAGGQSYYSTTTAPNYSSTIPLNTATHPSTLPYIVPVEDGLLLNTSSQSHSRDSPHSLTEVAFMQETHSTSQTPTSTTANSVNIGSVNVQGGSRSGGGNVSPQHDLNTIGNTNKIASATIKWLSRNYETAEGVSLPRSTLYNHYIQHCNESKIEPVNAASFGKLIRSVFAGLRTRRLGTRGNSKYHYYGIRIKPESVLNQIPDEKPAFQIQIPNTAHMTQNQSQNPMTPCSSSPIAGTSSTLHSGGTNNMLHNSRYSKKTHSFKTETHEACGQFIGDGGGAIPSFPTIELDNTFDSELTQEDVETFRSMYREHCENFLDAVLNLEFNTIEFLWRDFWRENSSMDECTEEEKYLTKAKLYLMCHCTGVQKFVREIDYQFYQNIVDVIIPDVLRSIPNSLTQAIRNFAKNMEIWLCESMIGVPERMVQIKSSAVSAFCQTLRRYTSLNHLAQAARAVLQNSGQITQMLNDLNRVDFHNVQEQAAWVCQCEPAIVQRLENDFKSALQQQSSLEQWAAWLQVVVESALQDYCGKPGYAKAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLYDEYMFYLVEHKIAEAHQKTAIAVICDLKHKEVEFDFGYQLEYIAADSVVNERGAKRMKHE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01373804;
90% Identity
iTF_00259519;
80% Identity
-