Agaa006541.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Autographa gamma
Gene Symbol
lz
Assembly
GCA_905146925.1
Location
LR989866.1:7536843-7548282[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.2e-17 6.4e-14 52.2 0.5 94 129 5 40 2 40 0.96

Sequence Information

Coding Sequence
ATGAAATCACGTAAATCGTTTACGTTAACGATAACAGTATCGACGACGCCGCCGCAAGTGACGACGTACAACAAAGCCATCAAGGTGACGGTGGATGGACCTCGGGAGCCGAGATCTAAGACCATGCTGTCTCTCCTAGGGCAGCAGCAGCAGTTCCACTTCGCGTTCGGGCAGCGCCCGTTCCCGTTCCCGCCGGACCCGCTCGGAGGGTTCCGTATGCCGCCCATCACTACCTGCCAAAACATGAGTCAATTCGGGTTAAGTTCGAGCAACTCGCACTGGGGCTACGGCGGCGCTGGCGCGTACCCGGCGTACCTGCCGTCGTGCGCGGCGCCCGCGGCCTCGCAGTTCAACCCGCCTGCACTCGGCTTTGCCGGCACCGTGCCTGATCAAACGCCCACGCAGGATTTTACGGCTAATAATACTGTGTTACCGGACACGACGGGCGTCGATTTAGACCAGCAGTTGTCGGGCCTAGTGGGCTCGTCACCGTCGCACCACGGCAGCCTTCTGCCGCGCTACAACAACAACACCGACTACAGCCTCTCGACAGGCCCGCGCTCACTCAGCGACAACAGCTCGCAACCAGAGTCCCCCGTCCAGGACGATCTCCTCACATCAAACACGACCACCAACATCGGACACAATCACACAAACAGCTCCAACTTCCCCTCACTAATGGGATCACAAAACTCATCGTACGGCAGCAGTAACTGCAACAACTCGCTGTACCCCGTCCTCCCCGCGAGCTTGTTATACAGCCAGCTGTACACGGCAGCCAACCAAACACACAACTTCCACCCGCTGCATTCGAACTCGATACATTCAACGCAAAACCACCACAACGAACTGCAAACTATGATGGATCAGATCTCGTCGACGACGAACAATCACCGGCAGCACGGGAACCACGGGCAGGAGCTGCTGCTGGGCGGCGGCAACTCGTGCGCGGCGGCCGCGGCCCGGGGCGAGGACGGCCGGGTCAACAACCTCGGACAAAGAGGTAATCCGCAGCCAGACAGCAACACGGTGTGGCGACCCTACTAA
Protein Sequence
MKSRKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFPFPPDPLGGFRMPPITTCQNMSQFGLSSSNSHWGYGGAGAYPAYLPSCAAPAASQFNPPALGFAGTVPDQTPTQDFTANNTVLPDTTGVDLDQQLSGLVGSSPSHHGSLLPRYNNNTDYSLSTGPRSLSDNSSQPESPVQDDLLTSNTTTNIGHNHTNSSNFPSLMGSQNSSYGSSNCNNSLYPVLPASLLYSQLYTAANQTHNFHPLHSNSIHSTQNHHNELQTMMDQISSTTNNHRQHGNHGQELLLGGGNSCAAAAARGEDGRVNNLGQRGNPQPDSNTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00757914;
90% Identity
iTF_00971009; iTF_01506945; iTF_00824484; iTF_01506118; iTF_00843280; iTF_01079670; iTF_01080508; iTF_00783202; iTF_00834403; iTF_01076163; iTF_01279043; iTF_01386499; iTF_00017956; iTF_00075236; iTF_00859236; iTF_00935460; iTF_01082212; iTF_01491652; iTF_00076229; iTF_01331205; iTF_01561797; iTF_00357193; iTF_01193391; iTF_00896550; iTF_01547302; iTF_00836295; iTF_00907655; iTF_00341992; iTF_00649800; iTF_01077960; iTF_00278889; iTF_00680297; iTF_01077961; iTF_01358665; iTF_00055178; iTF_00661056; iTF_00687691; iTF_00801579; iTF_01170347; iTF_01172107; iTF_00124012; iTF_01341996; iTF_00077265; iTF_00784173; iTF_00796301; iTF_00825358; iTF_01192398; iTF_01438670; iTF_00074255; iTF_00284303; iTF_00780815; iTF_01415599; iTF_01416549; iTF_01429711; iTF_00250239; iTF_01494095; iTF_00249493; iTF_00323248; iTF_00636048; iTF_00719984; iTF_00784976; iTF_01245712; iTF_01264176; iTF_01509360; iTF_00027537; iTF_00072497; iTF_00354865; iTF_00737251; iTF_00705764; iTF_01020964; iTF_00699877; iTF_01161093; iTF_00204908; iTF_00700780; iTF_00702669; iTF_00786544; iTF_00119386; iTF_00856380; iTF_00407345; iTF_00774289; iTF_00122130; iTF_01018354; iTF_00299925; iTF_00967829; iTF_01502741; iTF_00150262; iTF_00695254; iTF_01221270; iTF_01403222; iTF_00275022; iTF_00123127; iTF_00204151; iTF_00035417; iTF_00040569; iTF_00341113; iTF_00403545; iTF_01217271; iTF_01335705; iTF_00325146; iTF_00662010; iTF_00757914; iTF_01033498; iTF_00751803; iTF_01279963; iTF_01281083; iTF_00818140; iTF_01528057; iTF_01124380; iTF_00063357; iTF_00837245; iTF_00156030; iTF_00462149; iTF_00457022; iTF_00620999; iTF_01181681; iTF_00213193; iTF_00159605; iTF_00835326; iTF_00390140; iTF_01489918; iTF_00353855; iTF_00352815; iTF_01072223; iTF_01463939; iTF_00656919; iTF_01133499; iTF_00008677; iTF_00410055; iTF_00412298; iTF_00009780; iTF_00444884; iTF_01463034; iTF_00289403; iTF_00658139; iTF_00654012; iTF_00655872; iTF_00660084; iTF_00017120; iTF_00905888; iTF_01134560;
80% Identity
-