Gfla020598.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Gortyna flavago
Gene Symbol
lz
Assembly
GCA_963669345.1
Location
OY770144.1:11428815-11445166[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.4e-18 1.8e-14 54.2 0.2 93 129 22 58 19 58 0.97

Sequence Information

Coding Sequence
ATGGAACGTATAAAAGTTACAGTAAATATTCAAACAAACATCCAAAACGAAGAAAACATCGGCGGTAAATCGTTCACGTTAACGATAACCGTGTCGACGACGCCGCCGCAAGTGACCACGTACAACAAGGCCATCAAGGTGACGGTAGACGGACCCAGGGAACCACGCTCTAAAACCATGCTCTCTCTCCTAGGGCAGCAGCAGCAGTTCCACTTCGCGTTCGGACAGAGACCCTTCCCGTTCCCCCCGGACCCGCTAGGAGGGTTCCGGATGCCACCCATCACTACCTGCCAGAATATGAGTCAATTCGGTCTAAGTTCGAGCAACTCGCACTGGGGCTAcggcggcgcaggcgcataTCCAGCGTATTTGCCGTCGTGTGCAGCGCCGGCTGCGTCACAGTTCAACCCTCCGGCGCTGGGCTTCGCCGGAACCGTGCCTGACCAGACTCCCACGCAAGACTTTACGGCTAATAATACAGTTCTTCCGGACACGACGGGTGTTGATCTAGACCAACAGCTATCAGGCCTTGTGGGCTCCTCCCCATCGCACCATGGAAGCCTCCTACCAcgctacaacaacaacacaGACTACAGCCTCTCGACAGGCCCACGGTCACTTAGCGACAACAGTTCGCAGCCCGAGTCCCCCGTACAGGACGACCTGCTCACTTCAAACACGTCCACGAACATCGGCCACAATCACACAAACAGCTCGAACTTTCCTTCGTTAATGGGATCACAGAACACTTCGTACGGCGGCAGTAACTGCAACAACTCGCTGTACCCCGTCCTGCCGGCGAGCTTGCTATACAGTCAGTTATACACCGCCGCCAACCAGACGCACAACTTCCACCCGCTGCACTCAAACTCAATACACTCGACGCAAAATCACCATAATGAGCTACAGACGATGATGGACCAGATATCATCGACGACAAACAATCACAGACAACACGGGAATCATGGACAAGAATTACTCCTGGGCGGAGGAAATTCTTGCGCGGCGGCCGCGGCTAGGGGCGAGGACGGGCGGGTGAATAATCTCGGACAAAGAGGTAATCCGCAACCAGACAGCAACACAGTGTGGCGACCCTACTAA
Protein Sequence
MERIKVTVNIQTNIQNEENIGGKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFPFPPDPLGGFRMPPITTCQNMSQFGLSSSNSHWGYGGAGAYPAYLPSCAAPAASQFNPPALGFAGTVPDQTPTQDFTANNTVLPDTTGVDLDQQLSGLVGSSPSHHGSLLPRYNNNTDYSLSTGPRSLSDNSSQPESPVQDDLLTSNTSTNIGHNHTNSSNFPSLMGSQNTSYGGSNCNNSLYPVLPASLLYSQLYTAANQTHNFHPLHSNSIHSTQNHHNELQTMMDQISSTTNNHRQHGNHGQELLLGGGNSCAAAAARGEDGRVNNLGQRGNPQPDSNTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00971009; iTF_00077265; iTF_00715587; iTF_00834403; iTF_01076163; iTF_01279043; iTF_01545539; iTF_00017956; iTF_00075236; iTF_00859236; iTF_00935460; iTF_01020964; iTF_00204908; iTF_01082212; iTF_00462149; iTF_01245712; iTF_00325146; iTF_00156030; iTF_00341992; iTF_01561797; iTF_00649800; iTF_00635174; iTF_00680297; iTF_00412298; iTF_00801579; iTF_00953294; iTF_00246960; iTF_01170347; iTF_00666285; iTF_00895697; iTF_00702669; iTF_00699877; iTF_00700780; iTF_00784173; iTF_00275022; iTF_00825358; iTF_00284303; iTF_01429711; iTF_00636048; iTF_00823700; iTF_00784976; iTF_01264176; iTF_01452112; iTF_01547302; iTF_00072497; iTF_01331205; iTF_00354865; iTF_00737251; iTF_01463939; iTF_00705764; iTF_01161093; iTF_00410055; iTF_01438670; iTF_00887196; iTF_00323248; iTF_01509360; iTF_00027537; iTF_00660084; iTF_00658139; iTF_00655872; iTF_00656919; iTF_01335705; iTF_01528057; iTF_00662010; iTF_01463034; iTF_01133499; iTF_00856380; iTF_00661056; iTF_00407345; iTF_00122130; iTF_01544659; iTF_00444884; iTF_00159605; iTF_00967829; iTF_01502741; iTF_00150262; iTF_00695254; iTF_01506945; iTF_00824484; iTF_01506118; iTF_00796301; iTF_00843280; iTF_01403222; iTF_00123127; iTF_00035417; iTF_00040569; iTF_00161337; iTF_00162283; iTF_00403545; iTF_01217271; iTF_01436793; iTF_01358665; iTF_00427870; iTF_01166366; iTF_00783202; iTF_01491652; iTF_00076229; iTF_01416549; iTF_00907655; iTF_00278889; iTF_01172107; iTF_00124012; iTF_01341996; iTF_01192398; iTF_00074255; iTF_01415599; iTF_00719984; iTF_00299925; iTF_01221270; iTF_00341113; iTF_00185086; iTF_00017120; iTF_00905888; iTF_00119386; iTF_00923386; iTF_00751803; iTF_01134560; iTF_01279963; iTF_00390140; iTF_00654012; iTF_00818140; iTF_01080508; iTF_01079670; iTF_01543676; iTF_01542734; iTF_00063357; iTF_00837245; iTF_00835326; iTF_00836295; iTF_01489918; iTF_00250239;
90% Identity
iTF_00185086;
80% Identity
-