Basic Information

Insect: Heliconius nattereri
Gene Symbol: lz
Assembly: GCA_013403645.1
Location: JAAIXI010000212.1:1305956-1314785[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4e-18 1.1e-14 54.2 0.2 93 129 54 90 51 90 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4e-18	1.1e-14	54.2	0.2	93	129	54	90	51	90	0.97

Sequence Information

Coding Sequence: ATGAggcttttttttcagtttttcacGTGGACCGAGCCGCTTCTGGCCCATTACATGTCACCACCCCCACCCCCCACCCGCGGGTGGAAAAATCAGAAAATCGGTATTGGTTGTATCCCGCAGCGAGCCAAAGCGCCCCGCAATACAGCTTTGACGGACgGTAAATCCTTCACGCTGACGATAACGGTATCGACCACGCCGCCGCAAGTCACCACCTACAACAAGGCCATCAAAGTCACCGTCGACGGCCCCCGGGAACCGAGATCAAAGACcaTGTTGTCTCTCCTAGGGCAGCAACAGCAGTTCCACTTCGCGTTTGGACAGAGACCATTTCCGTTCCCACCAGACCCGCTCGGTGGTTTCCGAATGCCACCCATCACCACATGTCAAAATATGAGTCAATTTGGACTTAGTTCGAGTAACTCTCACTGGGGATACGGAGGCGCGGGAGCATACCCTGCTTACTTGCCGTCGTGTGCCGCGCCAGCCGCTACGCAATTCAACCCTCCAGCACTTGGCTTTGCTGGGTCTGTTCCTGATCAAACACCTACACAGGACTTTACAAACAACACTGTTCTGCCGGATACGACGGGCGTTGATCTGGACCAGCAGCTGTCTGGACTCGTCGGGTCGTCTCCGTCGCACCACGGGAGCCTCCTTCCCCGATACAATAACAACACGGATTACAGTTTATCAACGGGTCCCAGATCGCTGAGTGACAACAGTTCCCAGCCGGAGTCGCCAGTTCAGGATGACCTTCTAACATCTAACACAACAAACCTTGGCCACAACCATTCAAATAGCTCGAATTTTCCATCACTAATGGGATCTCAGAATTCATCGTATAATAGCAATTGCAATAACTCCTTATATCCAGTATTACCTGCTAGCCTGTTGTACAGTCAGCTATATACCGCCGCCAACCAAACGCATAACTTCCACCCGTTACACTCAAACTCCATCCACTCCACGCAAAATCATCACAGCGAGTTGCAGACGATGATGGATCAGATATCATCGACGACAAATAATCATCGTCAGCACGGCAGCCACGGGCAGGGGGACCTGTTGTTGGGGGGAGGCAACTCGTgtgcggcggcggcggcgcgggGGGAAGACGGCAGGGTTAATAGTCTCGGACAACGAGGTAATCCCCAACCAGATAGCAACACTGTGTGGCGGCCGTATTGA
Protein Sequence: MRLFFQFFTWTEPLLAHYMSPPPPPTRGWKNQKIGIGCIPQRAKAPRNTALTDGKSFTLTITVSTTPPQVTTYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFPFPPDPLGGFRMPPITTCQNMSQFGLSSSNSHWGYGGAGAYPAYLPSCAAPAATQFNPPALGFAGSVPDQTPTQDFTNNTVLPDTTGVDLDQQLSGLVGSSPSHHGSLLPRYNNNTDYSLSTGPRSLSDNSSQPESPVQDDLLTSNTTNLGHNHSNSSNFPSLMGSQNSSYNSNCNNSLYPVLPASLLYSQLYTAANQTHNFHPLHSNSIHSTQNHHSELQTMMDQISSTTNNHRQHGSHGQGDLLLGGGNSCAAAAARGEDGRVNSLGQRGNPQPDSNTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01386499; iTF_01078852; iTF_00896550; iTF_00213193; iTF_00357193; iTF_00687691; iTF_01193391; iTF_00786544; iTF_00774289; iTF_01181681; iTF_00620999; iTF_00782418; iTF_00775042; iTF_00777782; iTF_00204151; iTF_00261626; iTF_00457022;
90% Identity: iTF_00185086;
80% Identity: -