Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8.5e-30 7.3e-26 90.2 0.2 2 65 10 74 9 74 0.98

2 3 1.2 1e+04 -3.2 0.0 14 38 86 110 80 113 0.54

3 3 1.1 9.1e+03 -3.0 0.0 12 28 161 176 158 180 0.62

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8.5e-30	7.3e-26	90.2	0.2	2	65	10	74	9	74	0.98
2	3	1.2	1e+04	-3.2	0.0	14	38	86	110	80	113	0.54
3	3	1.1	9.1e+03	-3.0	0.0	12	28	161	176	158	180	0.62

Coding Sequence: ATGGCAGATAGTCAACAGAGCCGATTCGAGAAGTCGCTAGGATTGCTGACTACTCGTTTCGTATCTTTACTCCAGAAAGCGAAGGACGGCGTGCTGGATTTGAAAGTCGCCGCAGACCTTCTGGAGGTACGACAGAAACGGCGCATCTATGATATTACCAATGTGCTTGAAGGTATTGGTCTTATAGAGAAGAAGAGCAAGAACAGCATTCAATGGAAGGGTGCAGGACCTGGCTGCAATACACAAGAAGTCGGCGAAAAACTGACAGATCTAAAGGAAGAGATCAGCAAATTGGAGGATCACGAACAGCTGTTGGATACCCATACCCGATGGATTCAGcaaagcataaaaaatataaaagatgataatataaataagaaatatgcatatatcaCATACGAAGacgttaaagaaaattttgtggATCAATTTGTACTAGGAATACAGGGTCCTCCAGACATGGAAATAACAGTACCAAATGTTTTGAAGACTGTCATGCAAGAGGATACagtgataaattataacatgacTCTGAAAAGTAACTTGGGAGAAATTAAAGTGTATATGGTCCAACCTGAATTAGCTAAAACTTATGATAATAAAGTGTTAGAAATGAGATTACGAGAAGAGATAATAAAAGGTACAAAGCGCGGAAATGAAGATGAGAAGAAAGAGGAAGTTACTGTTAAACCAAAGAGGAAAGTTGGAAGGCCACCAAAAAACAGTACTAAACCAGATCCGATATTAACTGatgatgaagaagaagaagattcGGAATTAATAGAAGCTAAGATAGTCTTACGTGATGTAAGCACCGCagatattgtcCAAAGAGATTTGGAGTTTCTTGATCAATTGTATTCTGACTTTTGTGGACCATTGATGAGATTAAGTCCACCTCCTGGGGAAAAAGATTATCATTTCAATCTTAGTGAGAACGAAGGTGTTTGTGATTTATTTGACATTACGACATAA
Protein Sequence: MADSQQSRFEKSLGLLTTRFVSLLQKAKDGVLDLKVAADLLEVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGAGPGCNTQEVGEKLTDLKEEISKLEDHEQLLDTHTRWIQQSIKNIKDDNINKKYAYITYEDVKENFVDQFVLGIQGPPDMEITVPNVLKTVMQEDTVINYNMTLKSNLGEIKVYMVQPELAKTYDNKVLEMRLREEIIKGTKRGNEDEKKEEVTVKPKRKVGRPPKNSTKPDPILTDDEEEEDSELIEAKIVLRDVSTADIVQRDLEFLDQLYSDFCGPLMRLSPPPGEKDYHFNLSENEGVCDLFDITT

Sequence clustering based on sequence similarity using MMseqs2