Basic Information

Gene Symbol
znf423
Assembly
GCA_001594045.1
Location
NW:1206271-1295818[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 7.2e-06 0.00038 19.9 1.5 1 23 92 114 92 114 0.98
2 21 0.067 3.6 7.4 4.9 1 23 120 142 120 142 0.98
3 21 2e-06 0.00011 21.7 2.3 1 23 148 170 148 170 0.99
4 21 0.00012 0.0062 16.1 0.2 1 23 176 198 176 198 0.99
5 21 0.0063 0.33 10.7 2.2 1 23 362 385 362 385 0.94
6 21 0.37 19 5.1 0.0 3 23 398 419 396 419 0.88
7 21 0.71 38 4.2 0.1 3 23 487 507 486 507 0.97
8 21 0.0066 0.35 10.6 0.7 3 23 523 543 521 543 0.95
9 21 0.00034 0.018 14.7 0.8 1 23 552 575 552 575 0.92
10 21 2 1e+02 2.8 0.2 1 23 580 603 580 603 0.92
11 21 0.066 3.5 7.5 2.7 2 23 683 704 682 704 0.96
12 21 0.013 0.71 9.6 0.1 1 23 709 732 709 733 0.93
13 21 2.8 1.5e+02 2.3 0.1 2 23 797 820 796 820 0.81
14 21 0.00032 0.017 14.7 1.1 2 23 836 858 835 858 0.96
15 21 0.0045 0.24 11.1 1.0 1 23 867 890 867 890 0.93
16 21 1.1 59 3.6 0.8 2 23 898 919 897 919 0.95
17 21 0.02 1.1 9.1 0.2 2 23 1084 1106 1084 1106 0.96
18 21 0.033 1.8 8.4 1.1 1 23 1117 1140 1117 1140 0.96
19 21 1.2 64 3.5 0.1 2 23 1153 1174 1152 1174 0.94
20 21 0.019 1 9.1 0.1 2 23 1183 1205 1182 1205 0.94
21 21 0.063 3.4 7.5 2.6 1 23 1212 1235 1212 1235 0.97

Sequence Information

Coding Sequence
ATGCTTTTCAAAGGCAACAGTTCACGGCTGGAATTGTTGATTGGAAAGATCCACGCACACAAGGAACCGTCACAGGATGAGCAACATAAATCTAAAGAGGCCCTAGGAACCGGAAGTTCCTCGTGGCATAGTGAGGATGGCGGGCCCAACTCGCGTCGCGGCGGCGAGACGCCGTCCTCCTGCGCAACGCCGACATCAGCCAGCTTCCCATCGGAACCCGAGGTTGATGTCGACGTCAACGTCAATCTCGATGGCAATAACCCCGCTGCTCCGTACCCATGCCAATTCTGCGACAGAACGTTCCCGCGGCTCAGCTATCTGAAAAAACATGAACAGAGTCACGGTGATCAGATGCCATATCGATGCAGTTGGTGTAACAGATTATTCAAACACAAGCGCAGTCGGGATCGTCACGTGAAGTTACACACCGGAGACAGGCGATACCGCTGCTCGAAATGTGAAGCCGCCTTCTCTAGAAGCGATCACCTGAAAATCCACTTGAAGACACACGACACCCAAAGGCCTTACCAATGCACGGCTTGCACGAGAGGCTACAGCTCAGCCGCTGCCTTGACATCGCACATGCAATCTCACAAGAAGCATCACCAGTCATCGTCCTCTCAATCAGTTAGCAAGGACGTCGATTACGGTCGGAGAAGCGTCTCCTCGCACAGCACATCATCACCACCGGTGCCGTCATCGCCGTCACCGTCATTGAATCTCAGTCTGAATTCAAGGAATGTCCTGAAAACGTCGCAGGATACTGGTAGTACTTCTACTACACCGATTCTCAATTCGCCCCTGAAACTCGCTTGCATGTACTGCACTCGAGATTCGTTCAGCTGCATGCAGCAGCTGCAGATGCACGTACGTACAATGCATCAGGCAATCCTTAGCGGCGCGGAGAGTTTGGCACGACCACCATCGCCGAGCAGAACGTCGAACGAGCAGCAAACAATATTCTGCTCGCGCGACAAACCCGATCGTCAGGACAGCTCAAAAGATCCACGCTCAGATCAAAAATACCCGCCCGAGGAAAGAGCTGACAAGCCAGCAAGCGAACGAGATCACTACGAGAACGCGTTTACCTGTGACCAATGTACTATGAAATTCTCCACTCTGGCCTGCTTGCGCGATCATTCACTGTCGATACACCGAGTAGACAGTGGTTTCAGCGCTACAATGGTGATATGCCCGTTGTGTGGTATTCCGTGCACTTCAACAGCAGCCTATGCCGAGCACTATGTTCTCCAACACTGCGAAAATCGTCGCCCAGCACAGACAACCAGTATAGATTATAGCGAGACGAAACTGAACGGCGTTTACAACAGTACCCCAGAGAGAGACTCCAGAATGTCGCGAAGCAGAGATGTCCTGGAAGCCGCTAATCTCACGAATAAACGTTCGACTCGATCATCCGCGGACGTCGCTGGTAGCTATACCGCTGACACTTTATTGTGCGGCCAATGCGACGCCGCACTGAAGGATTTTGAATCCTTTCGCGAACACGTAGCTCGGCATCTGCAAGCCGACCACCGTAATCAAGAGACCAACAGGCAACATTTGTGCCCCAAATGTGAGATGAATTTCCCGTCTCGCGAAGACATGCTGGCTCACTTAACCAAACATTACGTAGGACAGATCAGCAAAGAATTCATATGCGGCGCCTGTAAAAAGTTCTACTCGCATCCAGATCAGCTTCAAAGACATTTGTTGGATGTGCATGCGCATCATTTGTATCGTTGCGCTCTGTGTCGGGACACGTTCGATTCCAAGGTAGCGATACAGGTGCATTTTGCAGTCAAGCACAGCCAAGAGTGTCGAATCTATCGATGCAGTGTATGTACGTTATCCAACAACGAAAATTCGCCGCCGGGAACAAACGCGGCTCCTAGCGACAGCAGGAGCTTCTTTAGAAGCGAAGCTGAGATGGCGGCCCATGTGCGTAACGTGCACGCACCTCCTCCCATCGTTCCTTCCTTAACGAACAGTCCTATCAGAACAACAACAAGGAGTCCAGCTTCGACACCTAGTATTATCACAACGCGCTGTGTCTTTTGCGGGACCTGCTGCAGTTCGGAGCTTGAACTTCAGCTTCATCTGGCCAGTCATTCGGCCAGTCTTTATAGATGTCCCATCTGTAGAGAAGGTTTCGCAGTGGAGTTCCTGTTGGATCGACATGTCGCTCAGGTTCATCATCAGATAGTGCAAGATCATCAAGTGCCATCAGTTAGAAACAGAGAGAACGGACGCGTTCATCGATCGGCTAGAAATCAGGAAGAAACAAAATCTCTGAAGAGAGGCCGTTCACCAGCTTCAAGCAACAACAATTCCCTGAATCAACGTGACAATAACAATAAACGTTCAAATTATGGTATTTCCAGTCAGCAATGCGAGCTTTGCGAACGCGGTGAATTCGCGAACGAGGCCGAGTTGCAGGCACATAAGAAATTAGCTCACACGCCCCCCAAGTTGTCCAACAAGGCTTTATCTATCTTGAGCATGACGTGTGGCTATTGTGGCGAAGTTTGTCGCTCGCGAAACGAGCTGGAATCTCACACGAAGATTCAACATGCATCTAACGAGTCCAGTGGACGTCACAAATGCAATATCTGCGACGAAGTATGCCCATCCATCGCGAATTTGGCCGAGCACAAACTTCAGAAGCATTGCAAGATCCAATTAAGCGACATGTGTGTAGTGTGTCGTGGTTGTCTCACGTCGGAAAGTCAATTTCTGGATCACGTGCAAAGACATAGCTTGGATAATGTGGATCCGCAACAACGATTGGATAGTACGTTGCCTCATCTGCCCGCGCCATGCGTTGTATGTCGACAGACCTTGATCAGCGATTTGGAATGTCGTCTGCACGCGCGGCATCATTTACGAACGTCCTCAAGTTTGCGCAATATCGGTTCCAGCCCGACTAGTCCTGGTGGTGACAAAGGTCAAAATCAAGGTTGCTGCCTCTGTTTGCGCGATTTTGCAGCCGAAGACTTTGTCAATCTACCACCCAATCCTGCCAGTACAAGCGGACAGCTGCTCAGAGTCTGTAAACCGTGTTACATGCGACATTCTCAGGGACTGCCTATTCTGAACTCGACGACCTATGAACATAGAGCTAAATATGAGACGACTTGGCTCGCGAGCAAGGACGGCCAGTGGGACGAAACTAAGGATAAGTGGGAGCACGAGAAAGGACTCAATGTAGAGGACCGATTCAGGAACGAAGGGAACGCGGATAAGGAAAGATGCGAAAATTGCGGAGTGAAGTTTGAAGACTTCGAAGAAGCAGAGAAGCACAGGATCACCGAGCATGAAAAAGCTGTCGGTGGTGGCTCGAATACCTACACCTGCATACAGTGTCAAATGTCATTTTCAACTGAAGCCAAGATTCAGCAACACGTGAGGAAAAAACACTTGGAAGCATCCGGAAAAGCTTCCTTGGAGGCTTTACGTTGTCACTTGTGCTTATTCGAGGCCGCCAGTCCTATGCAGCtacaaattcatttaatagaGCACACTTTCGTCGGTTGTGCCGCTCTTAGTTGTTATATCTGCCAGTCGCTCTTCACAACTCCTATCGGTCTTCAGAATCATATGCTGCAAGAACATGGACTAGACGCGAGACCGTACGATTGCTCCAAGTGCACACTCAAATTCTTCTTCAGCGCGGAACTGGACCATCACGTACTGACCTTTCACCGTCCGGACTCTTCGTCAGTCGAGAGCGCTCATGAAACGAAGACTCGCGAGTCGAAAAAGCGCGATAACGATGTAACGGTGAAGGAGGAAGTAGTGCAAAGCGGTAAAGAAAAGGTGAAaaaggaggaagagaaagaagaggagGAAGTGAACGTGGACGATCAGGTGGGGCATCACGAAGAGGCTGAACGAAATGAACAGAAACTGAAGATAGAAATAAACAATGAGGCGACATCCGGCAGGATGGAATCATGA
Protein Sequence
MLFKGNSSRLELLIGKIHAHKEPSQDEQHKSKEALGTGSSSWHSEDGGPNSRRGGETPSSCATPTSASFPSEPEVDVDVNVNLDGNNPAAPYPCQFCDRTFPRLSYLKKHEQSHGDQMPYRCSWCNRLFKHKRSRDRHVKLHTGDRRYRCSKCEAAFSRSDHLKIHLKTHDTQRPYQCTACTRGYSSAAALTSHMQSHKKHHQSSSSQSVSKDVDYGRRSVSSHSTSSPPVPSSPSPSLNLSLNSRNVLKTSQDTGSTSTTPILNSPLKLACMYCTRDSFSCMQQLQMHVRTMHQAILSGAESLARPPSPSRTSNEQQTIFCSRDKPDRQDSSKDPRSDQKYPPEERADKPASERDHYENAFTCDQCTMKFSTLACLRDHSLSIHRVDSGFSATMVICPLCGIPCTSTAAYAEHYVLQHCENRRPAQTTSIDYSETKLNGVYNSTPERDSRMSRSRDVLEAANLTNKRSTRSSADVAGSYTADTLLCGQCDAALKDFESFREHVARHLQADHRNQETNRQHLCPKCEMNFPSREDMLAHLTKHYVGQISKEFICGACKKFYSHPDQLQRHLLDVHAHHLYRCALCRDTFDSKVAIQVHFAVKHSQECRIYRCSVCTLSNNENSPPGTNAAPSDSRSFFRSEAEMAAHVRNVHAPPPIVPSLTNSPIRTTTRSPASTPSIITTRCVFCGTCCSSELELQLHLASHSASLYRCPICREGFAVEFLLDRHVAQVHHQIVQDHQVPSVRNRENGRVHRSARNQEETKSLKRGRSPASSNNNSLNQRDNNNKRSNYGISSQQCELCERGEFANEAELQAHKKLAHTPPKLSNKALSILSMTCGYCGEVCRSRNELESHTKIQHASNESSGRHKCNICDEVCPSIANLAEHKLQKHCKIQLSDMCVVCRGCLTSESQFLDHVQRHSLDNVDPQQRLDSTLPHLPAPCVVCRQTLISDLECRLHARHHLRTSSSLRNIGSSPTSPGGDKGQNQGCCLCLRDFAAEDFVNLPPNPASTSGQLLRVCKPCYMRHSQGLPILNSTTYEHRAKYETTWLASKDGQWDETKDKWEHEKGLNVEDRFRNEGNADKERCENCGVKFEDFEEAEKHRITEHEKAVGGGSNTYTCIQCQMSFSTEAKIQQHVRKKHLEASGKASLEALRCHLCLFEAASPMQLQIHLIEHTFVGCAALSCYICQSLFTTPIGLQNHMLQEHGLDARPYDCSKCTLKFFFSAELDHHVLTFHRPDSSSVESAHETKTRESKKRDNDVTVKEEVVQSGKEKVKKEEEKEEEEVNVDDQVGHHEEAERNEQKLKIEINNEATSGRMES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01406753;
90% Identity
iTF_00182841;
80% Identity
-