Basic Information

Gene Symbol
znf423
Assembly
GCA_000143395.2
Location
NW:416653-503510[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 7.1e-06 0.00041 19.9 1.5 1 23 165 187 165 187 0.98
2 21 0.067 3.8 7.4 4.9 1 23 193 215 193 215 0.98
3 21 2e-06 0.00012 21.6 2.3 1 23 221 243 221 243 0.99
4 21 0.00012 0.0066 16.1 0.2 1 23 249 271 249 271 0.99
5 21 0.0062 0.36 10.6 2.2 1 23 435 458 435 458 0.94
6 21 0.36 21 5.0 0.0 3 23 471 492 469 492 0.88
7 21 0.7 41 4.1 0.1 3 23 560 580 559 580 0.97
8 21 0.0065 0.38 10.5 0.7 3 23 596 616 594 616 0.95
9 21 0.0002 0.011 15.3 0.8 1 23 625 648 625 648 0.93
10 21 2 1.1e+02 2.7 0.2 1 23 653 676 653 676 0.92
11 21 0.066 3.8 7.4 2.7 2 23 756 777 755 777 0.96
12 21 0.013 0.77 9.6 0.1 1 23 782 805 782 806 0.93
13 21 2.8 1.6e+02 2.2 0.1 2 23 870 893 869 893 0.81
14 21 0.00032 0.018 14.7 1.1 2 23 909 931 908 931 0.96
15 21 0.00065 0.038 13.7 1.3 1 23 940 963 940 963 0.94
16 21 1.1 63 3.5 0.8 2 23 971 992 970 992 0.95
17 21 0.02 1.2 9.0 0.2 2 23 1157 1179 1157 1179 0.96
18 21 0.054 3.1 7.7 0.8 1 23 1190 1213 1190 1213 0.96
19 21 3.1 1.8e+02 2.1 0.5 2 23 1226 1247 1225 1247 0.93
20 21 0.019 1.1 9.1 0.1 2 23 1256 1278 1255 1278 0.94
21 21 0.063 3.6 7.4 2.6 1 23 1285 1308 1285 1308 0.97

Sequence Information

Coding Sequence
ATGCTTTTCAAAGGCAACAGTTCACGGCTGGAATTGTTGATTGGAAAGATCCACGCACACAAGGAACCGTCACAGGATGAGCAACATAAATCTAAAGAATTACTTACTGGAAAAGCCTCAAATGAGGCGTCAAGTAACCCTGAGTTAACGAAGAAAGCGATCGCGCGAAATGTCTTGCCTGTTGAATGTAGTCTAGCACAATCAGGAATCGCGCAAGACCGCGATCTTTTTCGAGTCAGTCAAGGCTCGGGGGTTAATGGTACGAGTTTTACTGTTTGCGCTCAAGAACGATATAAAGGAACACATAACAGGCGAGAGGCCCTAGGAACCGGAAGTTCCTCGTGGCATAGTGAGGATGGCGGGCCCAACTCGCGTCGCGGCGGCGAGACGCCGTCCTCCTGCGCAACTCCGACATCAGCCAGCTTCCCATCGGAACCCGAAGTTGATGTCGACGTCAACGTCAATCCCGATGGCAATAACCCCGCTGCTCCGTACCCATGCCAATTCTGCGACAGAACGTTCCCGCGGCTCAGCTATCTGAAAAAACATGAACAGAGTCACGGTGATCAGATGCCATATCGATGCAGTTGGTGTAACAGATTATTCAAACACAAGCGCAGTCGGGATCGTCACGTGAAGTTACACACCGGAGACAGGCGATACCGCTGCTCGAAATGTGAAGCCGCCTTCTCTAGAAGCGATCACCTGAAAATCCACTTGAAGACACACGACACCCAAAGGCCTTATCAATGCACGGCTTGCACGAGAGGCTACAGCTCAGCCGCTGCCTTGACATCGCACATGCAATCTCACAAGAAGCATCACCAGTCATCGTCCTCTCAATCAGTTAGCAAGGACGTCGATTATGGTCGGAGAAGCGTCTCCTCGCACAGCACATCATCACCACCGGTGCCGTCATCGCCGTCACCGTCATTGAATCTCAGTCTGAATTCAAGGAATGTCCTGAAAACGTCGCAGGATACTGGTAGTACTTCTACTACACCGATTCTCAATTCGCCCCTGAAACTCGCTTGCATGTACTGCACTCGAGATTCGTTCAGCTGCATGCAGCAGCTGCAGATGCACGTACGCACAATGCATCAGGCAATCCTTAGCGGCGCGGAGAGTTTGGCACGACCACCATCGCCGAGCAGAACGTCCAACGAGCAGCAAACAATATTCTGCTCGCGCGACAAACCTGATCGTCAGGACAGCTCAAAAGATCCACGCTCAGATCAAAAATACCCGCCCGAGGAAAGAGCTGACAAGCCAGCAAGCGAACGAGATCACTACGAGAACGCGTTTACCTGTGACCAATGTACTATGAAATTCTCCACTCTGGCCTGCTTGCGCGATCATTCACTGTCAATACACCGAGTAGACAGTGGTTTCAGCGCTACAATGGTGATATGCCCGTTGTGTGGTATTCCGTGCACTTCAACAGCAGCCTATGCCGAGCACTATGTTCTCCAACACTGCGAAAATCGTCGCCCGGCACAGACAACCAGTATAGATTATAGCGAGACGAAACTGAACGGCGTTTACAACAGTACCCCAGCGAGAGACTCCAGAATGTCGCGAAGCAGAGATGCCCTGGAAGCCGCTAATCTCATGAATAAACGTTCGACTCGATCATCCGCGGACGTCGCTGGTAGCTATACCGCTGACACTTTATTGTGCGGCCAATGCGACGCCGCACTGAAGGATTTTGAATCCTTTCGCGAACACGTAGCTCGGCACCTGCAGGCCGACCACCGTAATCAGGAGACCAACAGGCAACATTTGTGCCCCAAATGTGAGATGAATTTCCCGTCTCGCGAAGACATGCTGGCCCACTTAACCAAACATTACGTAGGACAGATCAGCAAAGAATTCGTATGCGGCGCCTGTAAAAAGTTCTACTCGCATCCAGATCAGCTTCAAAGACATTTGTTGGATGTGCATGCGCATCATTTGTACCGTTGCGCTCTGTGTCGGGACACGTTCGATTCCAAGGTAGCGATACAGGTGCATTTTGCAGTCAAGCACAGCCAAGAGTGTCGGATCTATCGATGCAGTGTATGTACGTTATCCAACAATGAAAATTCGCCGCCGGGAACAAACGCGGCTCCTGGCGACAGCAGGAGCTTCTTCAGAAGCGAAGCTGAGATGGCGGCCCATGTGCGTAATGTGCACGCACCTCCTTCCATCGTTCCTTCCTTAACGAACAGTCCTATCAGAACAACAACAAGGAGTCCAGCTTCGACACCTAGTATTATCACAACGCGCTGTGTCTTTTGCGGGACCTGCTGCAGTTCGGAGCTTGAACTTCAGCTTCATCTGGCCAGTCATTCGGCCAGTCTTTATAGATGTCCCATCTGTAGAGAAGGTTTCGCAGTGGAGTTCCTGTTGGATCGACATGTCGCTCAGGTTCATCATCAGATAGCGCAAGATCATCAAGTGCCATCAGTTAGAAACAGAGAGAACGGACGCGTTCATCGATCGGCTAGAAATCAGGAAGAAACAAAATCTCTGAAGAGAGGCCGTTCACCAGCTTCAAGCAACAACAATTCCCTGAATCAACGTGACAATAACAATAAACGTTCAAATTATGGTATTTCCAGTCAGCAATGCGAGCTTTGCGAACGCGGTGAATTTGCGAACGAGGCCGAGTTGCAGGCACATAAGAAATTAGCTCACACGCCCCCCAAGTTGTCCAACAAGGCTTTATCTACCTTGAGCATGACGTGTGGCTATTGTGGCGAAGTTTGTCGCTCGCGAAACGAGCTGGAATCTCACACGAAGATTCAACATGCATCTAACGAGTCCAGTGGACGTCACAAATGCAATATCTGCGACGAAGTATGCCCATCCAGCGCGAATTTGGCCGAGCACAAACTTCAGAAGCATTGCAAGATCCAATTAAGCGACATGTGTGTAGTGTGTCGTGGTTGTCTCACGTCGGAAAGTCAATTTCTGGACCACGTGCAAAGACACAGCCTGGATAATGTGGATCCGCAACAACGATTGGATAGTACGTTGCCTCATCTGCCCGCGCCATGCGTTGTATGTCGACAGACCTTGATCAGCGATTTGGAATGTCGTCTGCACGCGCGGCATCATTTACGAACGTCCTCAAGTTTGCGCAATATCGGTTCCAGCCCGACTAGTCCTGGTGGTGACAAAGGTCAAAATCAAGGTTGCTGCCTCTGTTTGCGCGATTTTGCAGCCGAAGACTTTGTCAATCTACCACCCAATCCTGCCAGTACAAGCGGACAGCTGCTCAGAGTCTGTAAACCGTGTTACATGCGACATTCTCAGGGACTGCCTATTCTGAACTCGACGACCTATGAACATAGAGCTAAATATGAGACGACTTGGCTCGCGAGCAAGGACGGCCAGTGGGACGAAACTAAGGATAAGTGGGAGCACGAGAAAGGACTCAAAGTAGAAGACCGATTCAGGAACGAAGGGAACGCGGATAAGGAAAGATGCGAAAATTGCGGAGTGAAGTTTGAAGACTTCGAAGAAGCAGAGAAGCACAGGATCACCGAGCATGAAAAAGCTGTCGGTGGTGGCTCGAATACTTACACCTGCATACAGTGTCAAGTGTCATTTTCAACTGAAGCCAAGATTCAGCAACACGTGAGGAAAAAACACTTGGAAGCATCCGGAAAAGCTTCCTTGGAGGCTTTACATTGTCACTTGTGCTTATTCGAGGCCGCCAGTCCTATGCAGCtacaaattcatttaatagagCACACTTTCGTCGGTTGTGCCGCTCTTAGTTGTTATATCTGTCAGTCGCTCTTCACAACTCCTATCGGTCTTCAGAATCATATGCTGCAAGAACATGGACTAGACGCGAGACCGTACGATTGCTCCAAGTGCACACTCAAATTCTTCTTCAGCGCGGAACTGGACCATCACGTACTGACCTTTCACCGTCCGGACTCTTCGTCAGTCGAGAGCGCTCATGAAACGAAGACTCGCGAGTCGAAAAAGCGCGATAACGATGTAACGGTGAAGGAGGAAGTAGTGCAAAGCGGTAAAGAAAAGGTGAAaaaggaggaagagaaagaagaggagGAAGTGAACGTGGACGATCAGGTGGGGCATCACGAAGAGGCTGAACGAAATGAACAGAAACTGAAGATAGAAATAAACAATGAGGCGACATCCGGCAGGATGGAATCGTGA
Protein Sequence
MLFKGNSSRLELLIGKIHAHKEPSQDEQHKSKELLTGKASNEASSNPELTKKAIARNVLPVECSLAQSGIAQDRDLFRVSQGSGVNGTSFTVCAQERYKGTHNRREALGTGSSSWHSEDGGPNSRRGGETPSSCATPTSASFPSEPEVDVDVNVNPDGNNPAAPYPCQFCDRTFPRLSYLKKHEQSHGDQMPYRCSWCNRLFKHKRSRDRHVKLHTGDRRYRCSKCEAAFSRSDHLKIHLKTHDTQRPYQCTACTRGYSSAAALTSHMQSHKKHHQSSSSQSVSKDVDYGRRSVSSHSTSSPPVPSSPSPSLNLSLNSRNVLKTSQDTGSTSTTPILNSPLKLACMYCTRDSFSCMQQLQMHVRTMHQAILSGAESLARPPSPSRTSNEQQTIFCSRDKPDRQDSSKDPRSDQKYPPEERADKPASERDHYENAFTCDQCTMKFSTLACLRDHSLSIHRVDSGFSATMVICPLCGIPCTSTAAYAEHYVLQHCENRRPAQTTSIDYSETKLNGVYNSTPARDSRMSRSRDALEAANLMNKRSTRSSADVAGSYTADTLLCGQCDAALKDFESFREHVARHLQADHRNQETNRQHLCPKCEMNFPSREDMLAHLTKHYVGQISKEFVCGACKKFYSHPDQLQRHLLDVHAHHLYRCALCRDTFDSKVAIQVHFAVKHSQECRIYRCSVCTLSNNENSPPGTNAAPGDSRSFFRSEAEMAAHVRNVHAPPSIVPSLTNSPIRTTTRSPASTPSIITTRCVFCGTCCSSELELQLHLASHSASLYRCPICREGFAVEFLLDRHVAQVHHQIAQDHQVPSVRNRENGRVHRSARNQEETKSLKRGRSPASSNNNSLNQRDNNNKRSNYGISSQQCELCERGEFANEAELQAHKKLAHTPPKLSNKALSTLSMTCGYCGEVCRSRNELESHTKIQHASNESSGRHKCNICDEVCPSSANLAEHKLQKHCKIQLSDMCVVCRGCLTSESQFLDHVQRHSLDNVDPQQRLDSTLPHLPAPCVVCRQTLISDLECRLHARHHLRTSSSLRNIGSSPTSPGGDKGQNQGCCLCLRDFAAEDFVNLPPNPASTSGQLLRVCKPCYMRHSQGLPILNSTTYEHRAKYETTWLASKDGQWDETKDKWEHEKGLKVEDRFRNEGNADKERCENCGVKFEDFEEAEKHRITEHEKAVGGGSNTYTCIQCQVSFSTEAKIQQHVRKKHLEASGKASLEALHCHLCLFEAASPMQLQIHLIEHTFVGCAALSCYICQSLFTTPIGLQNHMLQEHGLDARPYDCSKCTLKFFFSAELDHHVLTFHRPDSSSVESAHETKTRESKKRDNDVTVKEEVVQSGKEKVKKEEEKEEEEVNVDDQVGHHEEAERNEQKLKIEINNEATSGRMES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01406753;
90% Identity
iTF_00182841;
80% Identity
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