Basic Information

Gene Symbol
-
Assembly
GCA_905333075.2
Location
HG995395.1:12747440-12819293[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 2.4 3.7e+02 3.7 0.9 2 23 490 511 489 511 0.90
2 17 0.0026 0.4 13.0 0.0 1 23 521 544 521 544 0.95
3 17 0.022 3.4 10.1 0.4 2 21 669 688 669 689 0.94
4 17 0.05 7.7 9.0 3.8 2 23 750 771 749 771 0.95
5 17 1.1 1.7e+02 4.8 0.7 1 23 783 807 783 807 0.91
6 17 0.00018 0.028 16.6 0.3 2 23 814 837 813 837 0.97
7 17 0.2 31 7.1 0.3 1 23 843 865 843 865 0.93
8 17 0.0047 0.73 12.2 2.9 1 23 871 893 871 893 0.98
9 17 0.5 77 5.8 0.6 2 20 904 922 904 924 0.90
10 17 0.21 33 7.0 0.2 1 23 1003 1025 1003 1025 0.97
11 17 2.9 4.4e+02 3.4 7.2 1 23 1032 1054 1032 1054 0.95
12 17 0.0019 0.3 13.4 1.8 1 23 1104 1127 1104 1127 0.95
13 17 0.00069 0.11 14.8 0.5 1 23 1134 1157 1134 1157 0.98
14 17 0.0053 0.83 12.0 0.2 2 23 1179 1201 1178 1201 0.96
15 17 0.00042 0.066 15.5 1.2 1 23 1248 1270 1248 1270 0.96
16 17 0.00017 0.026 16.7 0.1 1 23 1276 1298 1276 1298 0.97
17 17 0.00054 0.083 15.2 0.7 3 23 1306 1327 1304 1327 0.95

Sequence Information

Coding Sequence
ATGATGGAGCCGCAACCACCTCTGATCCTCTGCATGGAGAATGCGTCGGGTGAGGAAGTGGCGCTCAGGATAGAACCCGATGATAACTTCCAGATGTTTCTAGATAAAGCCAGGTTACTCCTAGGCTTTGACGTGGACATAAACTCGATAACCAGAAACCAGCCCGTTTCTCTATCAGAGAATGTTTATCAATTCTTAGTAAACGCGGAACAAAACTTACAAGCGGACGAACTAACACAAAACTTTGACCAAATGTTGGACACCAACGATGGAGCCAACGACTTGGTGTACATATTGGACGATGGCACACAAATCCGTGCTTCACAAATACACTTTGATAATGATGATCCTTTAGTAGATTTGACAGCTGagaaaataccttttgttaaatACGCTGACGACGTCACTGatgtagatgatgatgaaatacatATTCAGGAAactaaaaagattaatattgtTGAAAGTCCTGTGTCGAGATGGTCGAGTAAAAACTCGAGTCCAAAATGCAGTTTCGTTAACTCTCTTCCGTTCAAATTAGTATGTAATAATACATCAGGTTTCGAAGCTCAATTCACTAAATATTTAGAAGCAAATACAACTAAAACTTACGCTACCTTAAACCCAGTAACAACTCGAAATAAATCTCCAAAAAGCTTGATCAAAGATAATTTTAAGAACTACGATGATAGTTATCATAGGAACGACAACTTGTCTTATACTCGGGAAGAGATTCTGAACATGTTCAAAGACTCCCCGATGACCTCACTGCCGTATGACCAGGGTTACAGTGAGAGGAGACATGTTCGAAAGACGGACCCTTCAAGGCTTGTTCATAAGAATTGGAGTAAGCCTCTTTCTTACGTCGATATTGACGGAGTATTGATAGGGGAAAGCGAGAGccaaatatgttttatttgcGGCAAACATGTGGACAGCAACGTTGATAAATTGTACCTTTTTGACAACGAAGATCAAAGATTGTATAGGTGCTCACCACAGAAAAAAATGTCGACACAATTGAAAATTATCTGCGAGTGTTGTCTTAACGAAAATTTTACACCGTGTCGAATGAAAAGCGCAAATCAATTCTTAAATCCCGACGAATTTCTCGTCATAAGAAATAATCAGCAATATATCTTccaaaaggttaaaaacttcAATTTCGCACATCTAGGCAAAGCTAAAGAGATCATAAACAAGATAGAGAAGAAAATAGACAAAGAAGAGTTTGTTAAAGTCGAGATTGGTTCTGATGGTGAAATCATTACCAAGCCCATAGACACACGGTGTGATGACGTCATCATTGTTAAAGATGAGAAGAAGGAGGGTAGTTCGAGTGACGTAGAGATTGTAGAGCCGGAACCAGAGATAGATAATATCATAGACAATTTGGAGGAAGCTGACGAGGAGGTGAAAGAGTTTTTGGGGAAATATCAACGTGATGATAGTGAAGTTACTGAATTAAAATGCAGATTCTGTGAACAAATCTTCTCGGATCTGGCGGCAGTTACAGATCACTGTGAAACACACAAACATGACTTAGAAGATGGCGAAGTTTTTCCGTGTCCACTCTGCAATTATGGTTATGCAAATTTAAAATGGCTAAAAGCCCATGTGAAGGCAGCCCACGAAAAGACTGAAACccctaaaatattaaaagaagaaaatGAACCTATGAAACAGGAGAATGCAGATGACGGAGAAACTCCTGCTAAAGTATCACCGCCCATTGCGACTCGCACAAGGAGTTCTAGTAAAAAGGGAGATGGCGATAGAAAagAGAATGAAAAATCGGACGATGTTAAGGCTGAATCTAATACTCAGGCGACGGAGCCACCCATCATAAAAACGGAGGTAAAGCAAGAATCCCTGGACAGTAGTGAGGATGAGATCTGGATCGTTCAGACTGCTGATGCTGAAGCCACACAGGAGCTGCAGAAACTACTCTGCAGTGCCAAGgTTAAAGAAGATGGACAAGATGGTGAATCTGAAAAGACACCCAAATGTGTTAATTGCGGGCAAATATTCGCCAACGCAGATGGCCTGTCAAACCATCGCTGCAGAAGACGCAACCGTAAGCGGAAGTCCAAGGACAAccttatatgtatacctactgaGGAAGATTTTTTGAAGaGAGCTCAAGGACGCCCTCGACCAGCAGATACATCAATAGACAATGATCTTCTTACTATGcgtCCCCGAAAACGCCGCAACCGGGAACCCACGTCCAACCCTCAAGTGGTGACCTGCCACAACTGTAATGAGTCCTTCACGTCCAAAGTTAGACTCAAGTTTCATATGCAATTCCACGAAACGTCAAACCAAACCCGGTCAGACGGGCGCTACTCCTGCTCCGAGTGTGACGACGCCACCTTCGCCACGGAGACGGAGCTCTTCGACCACGTCCACTTCCAACATGACAAGCAGAAGAGGTGGCAATGTCCCGTCGAGGGTTGTGGGAAGACTTTCTTCCTCAGGGCAACCTTAACAAAACACAGTCGCACGCATACGGACACACGGCGCTACGTGTGTGTTACATGTGACAAGAGATTCTTAGATAAACAGACGTTAGATGAGCATGGAGTTACACATTTACAGATAAAACCCTTCCAATGCCACATATGCCTGAAGCAGTTAACCCGTCGCTCGCGCTTGCGTATGCATGTGCGTGCGCACGAAGAGGAGTTGGCGCCGAGGCTTGTGCGCGTCTGTGCGGTCTGCAAGAGGGCTTTTAGAGATCATCGGCATGCACAGGAGCACGCATCAAAATCGACGGAATGTATCGAAGCTTTCGCAAACGAGTTAAAAGAAGAGGCTGAAGAAGTATCTATGCAGTTGTCGCCTACCAGTGGTTTAGTCAGACATACTGTGCAGGTTGTTGAATCTCCAAAGCTATCAAAGCCGATAAAACGACAGGTGACGAACGAAGTGGGCGAGCCACTTCTATCTCAGTTAGCTGATGAAGCGCGCGCTTTGATAAGGGTGGTCGAGATTGAGAAGGCGTTCCGCTGCGAGTATTGTGAAGAtgTGTTCTATTTGGAGACCGGTCTGAACACGCACCGCGCTATACACAAAGGAGTCAAGAATCCCTTCACTTGCCACATATGTAAAGTTAGCTTCGCTACTTATTCCAGATGCACAACCCACAAAACAACCCACGGCTTCTACAAGCGCTCACTAGCCGATGCTAAAAAACAAGCCGATGCTAAGAAACAAGCCGATGGCCCCGCACAAGCCGACGCCGACTCCTCCGCACGCTCTGCCACTGGCATACTGGGATACGGTGACTTTCCAGTCGTCAAACACTTCCTATGCGAGGACTGCGGCCGCTCATACCTGCACTGGACATACCTTCAAGTACACAGGCGCATGAAACACGCCAACGAGAACTTTCTGTACAAATGTAACCAGTGCGAACTTACCTTTCCGAACAGCTGGGGCCTGGCGTACCATCGTAAGAAGGTGCACGGCAAGACTGGAGCTGACGACCCTGGGACCACTAGCAAGAGCAGCAGGGACGATTATAGGATACCGTGTCGGGATTGTGATGAGGTGTTGCCGAACAAAACAGCTTTATACAAGCATCGTAAGAAAGAACACAGCGATGGAACTACTCGGGGTTATACTAAACCGgAACTTATCATTTTCAATCTTAGAGACGTCCACGGCAAAGAAGACGAGTCCTGCCTATCCTGCAACAAGACATCGACCACAGAAGGGACATGTCCCCGCCGTCCACACGCGTGTCCCGTCTGTGGACACGCCTTCCGGACACTTTCTATGCGAAATGAACATCTGAGGGTACACACAGGGGAGAGACCCTTTCCTTGTGATGTGTGTGGAGTTGCGTTCAGGAGGTCCACAGCTATGCGGAACCACCGCCTCATCCACACGGGCGTGCGCGCGTGGGCGTGCGGGCGCTGCCCCAAGCGCTTCCGTATCCGCTCCGACCTGCGCACGCACCTGCGGCTCAAACATCCTGCTACTATTGTAGTTGTAGAGATGGAAGGCCTAAACCCGTCGTCTGATGAAGTACTGAAGGCGCTCGCTGCACAAAACGTTCCACACGACAAACTTATAGATATCACTAAGATCTCATTCACGAAGGGCTCAACGAGTGTGATCCCGACGTGCACGCGCGCACTGTCCGCCCTCAACAACGTGCCGCGCACGCACGTCGCGTGCATCAAGCCCGCACCCGCACTGGAAGAATTTCAACCTGCTCGACGCGGTCGTGGCATCGCTAAAAACCCGCGGAGACCCAAAATACTACAGCGAGGGGAAGCGGAGCCACACGACAACTCTGCCTACCCCATCGTTGGTGGCGAAgaGCTATCAGATCTGAACGTGCAGCTCCTGCTACGGGATGGCGTGCTAGTGAACAGCAACCAAATGGTTCAGCTACAGTTAGATGACCCTATACTGATGGAGTGA
Protein Sequence
MMEPQPPLILCMENASGEEVALRIEPDDNFQMFLDKARLLLGFDVDINSITRNQPVSLSENVYQFLVNAEQNLQADELTQNFDQMLDTNDGANDLVYILDDGTQIRASQIHFDNDDPLVDLTAEKIPFVKYADDVTDVDDDEIHIQETKKINIVESPVSRWSSKNSSPKCSFVNSLPFKLVCNNTSGFEAQFTKYLEANTTKTYATLNPVTTRNKSPKSLIKDNFKNYDDSYHRNDNLSYTREEILNMFKDSPMTSLPYDQGYSERRHVRKTDPSRLVHKNWSKPLSYVDIDGVLIGESESQICFICGKHVDSNVDKLYLFDNEDQRLYRCSPQKKMSTQLKIICECCLNENFTPCRMKSANQFLNPDEFLVIRNNQQYIFQKVKNFNFAHLGKAKEIINKIEKKIDKEEFVKVEIGSDGEIITKPIDTRCDDVIIVKDEKKEGSSSDVEIVEPEPEIDNIIDNLEEADEEVKEFLGKYQRDDSEVTELKCRFCEQIFSDLAAVTDHCETHKHDLEDGEVFPCPLCNYGYANLKWLKAHVKAAHEKTETPKILKEENEPMKQENADDGETPAKVSPPIATRTRSSSKKGDGDRKENEKSDDVKAESNTQATEPPIIKTEVKQESLDSSEDEIWIVQTADAEATQELQKLLCSAKVKEDGQDGESEKTPKCVNCGQIFANADGLSNHRCRRRNRKRKSKDNLICIPTEEDFLKRAQGRPRPADTSIDNDLLTMRPRKRRNREPTSNPQVVTCHNCNESFTSKVRLKFHMQFHETSNQTRSDGRYSCSECDDATFATETELFDHVHFQHDKQKRWQCPVEGCGKTFFLRATLTKHSRTHTDTRRYVCVTCDKRFLDKQTLDEHGVTHLQIKPFQCHICLKQLTRRSRLRMHVRAHEEELAPRLVRVCAVCKRAFRDHRHAQEHASKSTECIEAFANELKEEAEEVSMQLSPTSGLVRHTVQVVESPKLSKPIKRQVTNEVGEPLLSQLADEARALIRVVEIEKAFRCEYCEDVFYLETGLNTHRAIHKGVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRSLADAKKQADAKKQADGPAQADADSSARSATGILGYGDFPVVKHFLCEDCGRSYLHWTYLQVHRRMKHANENFLYKCNQCELTFPNSWGLAYHRKKVHGKTGADDPGTTSKSSRDDYRIPCRDCDEVLPNKTALYKHRKKEHSDGTTRGYTKPELIIFNLRDVHGKEDESCLSCNKTSTTEGTCPRRPHACPVCGHAFRTLSMRNEHLRVHTGERPFPCDVCGVAFRRSTAMRNHRLIHTGVRAWACGRCPKRFRIRSDLRTHLRLKHPATIVVVEMEGLNPSSDEVLKALAAQNVPHDKLIDITKISFTKGSTSVIPTCTRALSALNNVPRTHVACIKPAPALEEFQPARRGRGIAKNPRRPKILQRGEAEPHDNSAYPIVGGEELSDLNVQLLLRDGVLVNSNQMVQLQLDDPILME*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00121732;
90% Identity
iTF_01247427;
80% Identity
-