Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.5e-05 0.035 12.4 0.1 20 53 5 38 3 39 0.89

2 7 0.00011 0.26 9.6 0.0 20 52 61 93 47 95 0.88

3 7 0.018 43 2.5 0.0 20 44 89 113 87 121 0.85

4 7 0.0006 1.4 7.2 0.3 21 53 118 150 115 151 0.88

5 7 0.0015 3.6 6.0 0.1 22 52 175 205 170 207 0.88

6 7 0.023 57 2.1 0.2 22 51 203 232 200 233 0.70

7 7 0.0012 2.9 6.3 0.0 20 44 229 253 226 260 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.5e-05	0.035	12.4	0.1	20	53	5	38	3	39	0.89
2	7	0.00011	0.26	9.6	0.0	20	52	61	93	47	95	0.88
3	7	0.018	43	2.5	0.0	20	44	89	113	87	121	0.85
4	7	0.0006	1.4	7.2	0.3	21	53	118	150	115	151	0.88
5	7	0.0015	3.6	6.0	0.1	22	52	175	205	170	207	0.88
6	7	0.023	57	2.1	0.2	22	51	203	232	200	233	0.70
7	7	0.0012	2.9	6.3	0.0	20	44	229	253	226	260	0.91

Coding Sequence: ATGTTCATTCACAGCTCAGAAAAACCGTTTGTTTGTGAAATTTGTAAATTCTCTACTCGATATCGATCAAATTTAAGGATACATGAGATGATGCACAGTTTGGTAAAACCATTTGTTTGTGAAACTTGTGGGTTTTCCGCTCGACGTAAGGGGACTTTGAAGGAACACATGATGATTCACAACTCAGATAAACCATTTGTTTGTAATACTTGTGGGTTCTCTGCTCGACGTAAGAGGGCTTTAAGGGAACACATGATGATTCACAACTCCGAAAAACCATTTCTTTGTGAAACTTGTGGGTTCTCTACTGGACGTAAGCGTACTTTAAAACAACACATAATTAATCACAGCTCAGTAAAACCGTTCGTTTGTAGAATTTGTGGTTTCTCTACTCGACATCAGTCAATTTTACAGAGACACATGCTCATGCACAGCTTGGAAAAACCATTTGTTTGTGAAACGTGTGGGTTTTCTACACAACTCCAATCAATTTTACAGAGACACGTGCTCAATCACAGCGTAGATAAACCATTTGTTTGTGAAACTTGTGGGTTCTCGACTCGCCGTCGTTATAATTTAAAAGAACACTTGACGATTCACAGCTCGCTAAAACCGTTTGTGTGTGAACCGTGTGGGTACTCTACCCAACGTAAGTCTACATTAAAGAGACACATGGTCATTCACAACTCAAGAAAACCATTTACTTGTGGAACTTGTGGGTTCTCGACTCGATATAAAATCAATTTAAAGAAACACATGATGAATCACAGCTCGGTAAAAAAACGCACAGTTTAA
Protein Sequence: MFIHSSEKPFVCEICKFSTRYRSNLRIHEMMHSLVKPFVCETCGFSARRKGTLKEHMMIHNSDKPFVCNTCGFSARRKRALREHMMIHNSEKPFLCETCGFSTGRKRTLKQHIINHSSVKPFVCRICGFSTRHQSILQRHMLMHSLEKPFVCETCGFSTQLQSILQRHVLNHSVDKPFVCETCGFSTRRRYNLKEHLTIHSSLKPFVCEPCGYSTQRKSTLKRHMVIHNSRKPFTCGTCGFSTRYKINLKKHMMNHSSVKKRTV

Sequence clustering based on sequence similarity using MMseqs2