Basic Information

Gene Symbol
-
Assembly
GCA_009739505.2
Location
CM019182.2:45364687-45426105[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00025 0.021 15.4 5.8 1 23 109 131 109 132 0.96
2 17 0.00062 0.051 14.2 0.9 2 23 149 170 148 170 0.97
3 17 3.2e-06 0.00027 21.3 0.7 1 23 176 198 176 198 0.97
4 17 2.9e-05 0.0024 18.4 0.8 1 23 204 226 204 226 0.98
5 17 0.0025 0.2 12.3 0.6 1 23 233 255 233 255 0.97
6 17 0.024 1.9 9.2 3.1 1 23 261 283 261 283 0.98
7 17 2.5e-06 0.00021 21.7 0.3 1 23 289 311 289 311 0.96
8 17 3.6e-07 3e-05 24.3 0.2 1 23 317 339 317 339 0.98
9 17 0.071 5.9 7.7 1.3 2 23 347 368 347 368 0.94
10 17 7.9e-06 0.00065 20.1 2.1 1 23 434 456 434 456 0.97
11 17 1.1e-05 0.00095 19.6 1.7 1 23 517 539 517 539 0.98
12 17 0.005 0.41 11.3 0.7 1 23 545 567 545 567 0.98
13 17 7.2e-06 0.0006 20.3 0.3 1 23 573 595 573 595 0.98
14 17 0.0012 0.098 13.3 3.2 1 23 601 624 601 624 0.94
15 17 0.0057 0.47 11.1 0.0 2 23 628 650 627 650 0.95
16 17 0.96 79 4.1 0.2 2 23 657 679 656 679 0.92
17 17 0.065 5.4 7.8 0.2 1 20 780 799 780 802 0.94

Sequence Information

Coding Sequence
ATGGCGGAAGTCCAGAAAATGGACGAAGGCTACAAAGAAGAATTCGTATTCGTCGAGGAATATTTCCCTTTAGATCTCCACGAAGAAGAAGTCGTCGCCGAACCAGTCGACGGCCAGGAAATCGTCGTTCAGCACTCCGAACACCAGGAAATCATCCACGATGTTCGATGCGTGGTTTCAGCAACCAACAGCATCCTCCCAGACAGCTATGACCCGACGGACCCTTCGCAGTGGGCTCAAGAAGAGGTCATCATCGAATCCTCGGAAAACCAACCAGTCGCAGCGGTCATCAAGCTGGAGACAGACGACTCCCAGTCACACGTCTACGAGTGCTACAAGTGCGCCAAGCGTTTCAACTACAAAGACAAGCTTTTCAAGCACATGAAACTCCATCATGCTCGTGGGGACGATGTCATGATTGAGCGGGATGGCAAGCGAATTTGGACCTGCACTCAGTGCGACAAGACCTTCATCTCTCGTAAAGGTTCTATCATTCACCAGCGCACCCACACGGGAGAAAGGCCGTATTCCTGCTCTGTGTGTCAGAAGAGGTTCATCGACTCTAGCACCCTTATGAAGCACCAGGTTATTCACCAAGCAGTTCGACCATTCAGCTGCCTGGTCTGCCGTCGAGGGTTCAACCAAAAAGTCGCTCTTCAGCGCCACGAGAGAACGCACGGTCAAATTCAGCCCAACTTCAAGTGCAAGTTCTGTCCCAAGACCTTCCTCGTCGGAAGCAGCTTGCAGGCCCACGAGAAGATACATTCCGGGATCAAGCCGTACACGTGCCAGTACTGCCCAAGCAGGTTCCACACATCCACCGCTCAGCGGCAGCACGAGCGAGTCCACACTAACGAGAGGCCTTACGCCTGTAGCTACTGTCCGAAAGCGTTCAAAGATTCAGGGACCCTCTTCAAACACCAAGTGATTCATTCTGGTATACGACCGTTCGTCTGTCCGATTTGCTCTCAAGGATTCACGCAGAAAGTCGCTTTGAGGAAACACATCCGTTCTCACGTCTCGAGGAACCACGACAACACCTGTGAGGTTTGCGAGAATCAGTTTTTCTCCAAAGAGGATCTCTGTACTCACGTGGAAGACCATATTGAACAACACCCAAGCATCACTCAGGTGAAAATCATTGCTACGTCCTCGATGAGAAACAAACAAGAACTTCTGGTTGCTGAAAACGTCGACAGACCTAATTCTCCGGAGCCTGAACGGACGGAAAGTGATCTCAGTGATTTGGCGACGCTGTGTGATGTGGCTATTTCCACTGCTGGCGACTTAGCACAGAGTTTCCCCTGCCTGCACTGCGGCATGACTTTCCGCAGAAAGAAATCGTTGGAATCCCATCTGACAATACACCGGACGTCTACTTCAGTGGAAGCTAGAGTGTCAAACGAAATAGAAGTTGAGGGTGGCACCATAATAGCGACTGGACCTTCGGAGACACTCGTCATCTCGAGTGGAAGCAACGATAAAGGAAGTGGCAAATCCTTGTCGCCTACGGGAGCCAATAGCGCCTCCAAACACCCTAAAAGGTTCTTCTATTGCGAGAGGTGTGATAAAACATTTTCGTCGCGAAACGGCTACATTATCCACCAAAGAAGCCACACCGGAGAACGTCCTTACCCATGCAGATGGTGTGAAAAAGCGTTTGGTGACTCGGCAACACGACACAAACACGAGCGCATCCACACGGGGGAGCGGCCATTCAAGTGTTCCAGATGTCCCCGCGCCTTCAACCAACGCGCTGCCCTCAGAGCTCACCAGGTCACCCACACAGTCGACCGGGCCTTCCTGTGCAAGTACTGCCCTTCGAGCTTCCCCTACTACGCCACCCTCAAGCGCCACCAGCAGTCTTGCCACTCTAGCCTGCCCTGCCCTTTGTGCGCCGCTGCTTTCCCCGACCCTAAGAAGCTCTTCGTTCACATCAAAAATATTCACGCTTTGGAGACTAATTTAACCTGCACCCTCTGCGACTCGGTGATGTTCACCGACACCACAGAGTTCTCTGAGCACATGGTCTGGCACGGGAAACAACAGCAAAACGATCCCAAGaTGGTCGACGCGGAAGTTGAAAAAGAAACGGAAACGCAAATCGAGATCATCACAACGCAAAATATCAAAGAAGAGAtcgtggaagaagaggaaatcgTCACGGAAGAAGTTTACACGACGGAAGTTACCTTTGAGGAGATGGGAGATGCCGAGACGACCTCGTTCGTGGAGGAAGGCTACTCGGAGGAGGTCTACACCCAGGATGACCCCGCCGTCGAGGAGATCATCGAGCAGACGATCGTCACTGAAGATTTCCCCATAGTCGACGGAGCCTACAGCTGCGACGTCTGCGGTCTTCTGTTCCACGAGAAAGAGGCGCTTCAAGAACACGTGCCGCTGCATTTCTAG
Protein Sequence
MAEVQKMDEGYKEEFVFVEEYFPLDLHEEEVVAEPVDGQEIVVQHSEHQEIIHDVRCVVSATNSILPDSYDPTDPSQWAQEEVIIESSENQPVAAVIKLETDDSQSHVYECYKCAKRFNYKDKLFKHMKLHHARGDDVMIERDGKRIWTCTQCDKTFISRKGSIIHQRTHTGERPYSCSVCQKRFIDSSTLMKHQVIHQAVRPFSCLVCRRGFNQKVALQRHERTHGQIQPNFKCKFCPKTFLVGSSLQAHEKIHSGIKPYTCQYCPSRFHTSTAQRQHERVHTNERPYACSYCPKAFKDSGTLFKHQVIHSGIRPFVCPICSQGFTQKVALRKHIRSHVSRNHDNTCEVCENQFFSKEDLCTHVEDHIEQHPSITQVKIIATSSMRNKQELLVAENVDRPNSPEPERTESDLSDLATLCDVAISTAGDLAQSFPCLHCGMTFRRKKSLESHLTIHRTSTSVEARVSNEIEVEGGTIIATGPSETLVISSGSNDKGSGKSLSPTGANSASKHPKRFFYCERCDKTFSSRNGYIIHQRSHTGERPYPCRWCEKAFGDSATRHKHERIHTGERPFKCSRCPRAFNQRAALRAHQVTHTVDRAFLCKYCPSSFPYYATLKRHQQSCHSSLPCPLCAAAFPDPKKLFVHIKNIHALETNLTCTLCDSVMFTDTTEFSEHMVWHGKQQQNDPKMVDAEVEKETETQIEIITTQNIKEEIVEEEEIVTEEVYTTEVTFEEMGDAETTSFVEEGYSEEVYTQDDPAVEEIIEQTIVTEDFPIVDGAYSCDVCGLLFHEKEALQEHVPLHF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

80% Identity
-