Basic Information

Insect: Aphis craccivora
Gene Symbol: FoxL1
Assembly: GCA_009835225.1
Location: VUJU01001319.1:1850-22383[+]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.1 9.6e+03 -2.5 0.0 11 31 40 60 37 91 0.64

2 2 5e-40 9.4e-37 125.7 0.0 1 87 136 228 136 229 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.1	9.6e+03	-2.5	0.0	11	31	40	60	37	91	0.64
2	2	5e-40	9.4e-37	125.7	0.0	1	87	136	228	136	229	0.90

Sequence Information

Coding Sequence: ATGAACCGCGGGGGCCAGCCCCAATCACCGGAACAGCCAAGTCATACCTCAGCCGCCGTGGACAGCATGAAGAACGAAGAGCCGACCATACCGAGTCATCACCAGCAGCGGAACATGTTGGCCGAGGCGATAGCGTCTCTGCCGCCAGTGCCTCAGAACTTGTCAGCCATCGCCCTGTTTCATCAGCTGCCCATACTGTACCAGCAGCACTACCAGCACATGTTGCATTCCCGCATTCTGCCCTACTTACAGGAATCTCTGAGGTTGCAGAGTTCCGTCAACTTTGTGGATAAGCCACAGATGCCGACGGTGCCGGCTATCAGCCTGTTTGACCAACCCTCCGAACAGAACGCGGCGGCCGCGGCTGCCGTCGCTGCCGCGGACATGGCGGCAGTCGGATGCAACGAGAAACCGCCTTACTCGTACATAGCGCTTATCGCCATGGCCATAACGTCCACTCCCAACCAGCGGATGACGCTCAGCGAGATTTACAACTACATTACGGACAAGTTCCCGTACTACCGGCGCAACAGACAGGGCTGGCAGAACTCGATCAGGCACAACCTGAGCCTGAACGATTGTTTCATCAAGATCCCGAGAGGCCGGACCGGCATGGACGACAACATGGGCGGCGGCAAGGGCAGCTACTGGACGCTGGACCCGGTGGCCGCTAACGACATGTTCGAGAGGGGCAACTACAGGCGGAGGCGGATGCGCCGGCATAGGCCGTACCAGCAGCAAAACCACCACCAGACGcaacagcaacagccgCTGACCAGTCCTCACCACCATCATCACCACCACTTCGCGGTGTACCCCGAGTTCCAGTTGACAGGCAGGAACGCAGCTGTGGCCGTGGCCGCCGCTGCCGAGTCGCTGGCGGACAAGCAGCACGCCGTGGCCGCCGTCGCGGACACGGTGTCCTCGCACAACCTGGCGTTCCACATCGAGAACCTGATACAGAAGAAGCACCGCGGCGTCGAGATGTCCCAGGAGGAGATCGTGTCGTCCAGCGGCGtgcacaacaacaacaacgatCTGCAGCAGTACGCGGCCGGCGACGACCATCCAAACCACAACCACcaccaacaacaacaacaacaacaccaCCACCGCCATCAGCACGCCGTCGAGTCCAAGCCAAAATTGATCATCATCAACGACGAGGACGACAGCAACATCAGTGGCGGCAGTGGCGGCAGACGCTGCTAA
Protein Sequence: MNRGGQPQSPEQPSHTSAAVDSMKNEEPTIPSHHQQRNMLAEAIASLPPVPQNLSAIALFHQLPILYQQHYQHMLHSRILPYLQESLRLQSSVNFVDKPQMPTVPAISLFDQPSEQNAAAAAAVAAADMAAVGCNEKPPYSYIALIAMAITSTPNQRMTLSEIYNYITDKFPYYRRNRQGWQNSIRHNLSLNDCFIKIPRGRTGMDDNMGGGKGSYWTLDPVAANDMFERGNYRRRRMRRHRPYQQQNHHQTQQQQPLTSPHHHHHHHFAVYPEFQLTGRNAAVAVAAAAESLADKQHAVAAVADTVSSHNLAFHIENLIQKKHRGVEMSQEEIVSSSGVHNNNNDLQQYAAGDDHPNHNHHQQQQQQHHHRHQHAVESKPKLIIINDEDDSNISGGSGGRRC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00018825;
90% Identity: iTF_01304666;
80% Identity: -