Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.7e-68 1.4e-63 215.4 23.9 1 154 29 182 29 183 0.98

2 3 5.2e-39 1.3e-34 120.3 6.4 178 300 182 304 181 304 0.94

3 3 0.024 5.9e+02 -0.0 0.3 122 161 304 343 302 344 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.7e-68	1.4e-63	215.4	23.9	1	154	29	182	29	183	0.98
2	3	5.2e-39	1.3e-34	120.3	6.4	178	300	182	304	181	304	0.94
3	3	0.024	5.9e+02	-0.0	0.3	122	161	304	343	302	344	0.82

Coding Sequence: atggaaTCAGCTATAACTGGGCGAAGGCGAACTGCTACACGACATTCTGCGGAAGATCAAGCACTCGATCAAATAGCTAAGGAGGCAGAAGCAAGACTGGCTGCTAGGAGACAGGCAAGAGCAGAAGCCAGGGAAATACGAATGCGTGAATTAGAAAGACAACAGAAAGAAGCAGAGGAGAATGCTGATAGGGTTTATGACATGTGTGCAGTTGATGTGAACAGAACTATGAGAGTAACTCCAGATCCAGTGCGTACATCGCGACTTCTTACAAATTCCAACAATTTTCAATCGAGTCGTAGATCTTCAGAAGATTCATTAGAAGATGCAGGATTAAGCAGAGATATTAGGcTGGAATTAAAGGAACTTGAAGAAAAATTCAGGAAGGCAATGATAGCTAATGCTCAGCTAGACAATGAAAAATCATCTTATGCCTACCAAGTTGATTTATTGAAAGATAAATTGGAAGAATTAGAGGAAACAACTGCACAATTACGTAGAgaattgagagagaaaaatcgaGATGTTGAACAATTAAAACGGgaaAACGGTTTAGTCATTGTTGACAATAAGGAAAGTGAAGATGAGGATAATGAAAATATGGAAAATGGACTATGTCATAGAAAAAGAGTACTAGTCAGTACAGAAGCTGCTGAATTATTAGAAACGGCTGGTAAAGGTTCACTAGATATTCGACTGAGAAAGTTTGCTTCTGAAAAAAAGGAATTGCAAGATGAAATTCGCCATTTAAGATTGGAATTAGAAGAAACTAAAAATCGTATGAGACCCGAAAAATCATCTGGCTCAATATTAGGTTGTTTATCAGATAACGAAGATATTCAACGTGAAGCAAATAAATTGTTGGccgattataaatttaaattacaaaaagcgGAACAAGATATGTCTACGTTGCAAGCGACAGTGGCTAGATTAGAAAGTCAAGTAATTCGTTATAAATCAGCTGCAGAAGCATCTGAAAAAGCGGAAGATGAGTTGAAAGTAGAAAAAAGGAAGTTGCAAAGAGAAGTatga
Protein Sequence: MESAITGRRRTATRHSAEDQALDQIAKEAEARLAARRQARAEAREIRMRELERQQKEAEENADRVYDMCAVDVNRTMRVTPDPVRTSRLLTNSNNFQSSRRSSEDSLEDAGLSRDIRLELKELEEKFRKAMIANAQLDNEKSSYAYQVDLLKDKLEELEETTAQLRRELREKNRDVEQLKRENGLVIVDNKESEDEDNENMENGLCHRKRVLVSTEAAELLETAGKGSLDIRLRKFASEKKELQDEIRHLRLELEETKNRMRPEKSSGSILGCLSDNEDIQREANKLLADYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREV

Sequence clustering based on sequence similarity using MMseqs2