Aepo001446.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Apamea epomidion
Gene Symbol
egg
Assembly
GCA_947507525.1
Location
OX382253.1:7404580-7439085[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2 5.9e+03 -2.6 0.0 29 38 580 589 550 590 0.65
2 2 1.9e-13 5.6e-10 39.1 0.0 4 73 621 683 618 687 0.88

Sequence Information

Coding Sequence
ATGACAGCTTTGGAATTAGAAAAAGCTCGAGAAACATCCAAATGCATCAACTATTGTTGCACGAGCGACAACAAAGTGCCCTACAAACTGGCGGAGCCGTCAGTGGTGGCGTACTACGACGCGGGCAGGAAGAGACGCTCCATGGTGTGCCAGCCATGCGCCGATGTGGTCACTGCTAGGAGTCAGAATCTAATCCAAGGCATAAAGGATCTAACTCCACTGATAGACCTGGATATGGACAAGTTATCACAAGACCTGGTGGAGATATCCGACTCGGAGTCTGAAGATGAGGTTACGAGTACTGAGGAACCTAAGGAGAGTATCGGAGAGAAGGGGGCTCAATTCATAGAAGAAAATCTGGCTAAGTATTTGAACGACACGTGGAAGAAGTACGACATGGACACACGCCTCAAAGAGACACAGATTATGCTAGATGATGAGATTGAGAAACTTGAACAGGACAGCAAAGAAATAGACGCAATGCTAAACGAGTGTCAGATAGCGACAGACAAGCTTCGCTGCGAGTTATACGCAACCTTCGAGTGTCGGCGAGAGAATCTACCCTCTTTAGTTATATACGACACGCCTGACTCTAAAACTCGTCAAGCTAAGCGGCGTTTGTCGTCACAAAGTGAGACGACTCCAGCCAAACGTCCCGCTATACCACTTGGATATGCTCCTTTAGATGGCGGCTACTCTAAGGAAAAAGCAGCAGTCCCCGCGCCAGACAACAAACTAGATGATGACAAAGATATATCAGTAGTGAAGCTATCAGCTGAAGCCGCCCCCGCAGACTTGCCCCCGCCCGGCGAGATCTCGCGCCCGCCGCTGCGCGTGGGCATGCCGGTGTACGCCATGAAGAACGCCTTCGGACCCTGGCTTAAAGGCAGAGTGGTGGAGATACAGCCGAAGAATACGAGTGGGGGCAACCCATTCTCTGTGTGTCTTGTGAAATTCGACCATAAAGTGAAGACGAATGGGAAAGTGTTGCACGCAAGATGCATCGCGTATTCTGAGCCCGCTGATGTTAGAATGACTATTGGTACTCGCCTCATAGCCCTGTTCAAAGATTCGAACAAGCGCGAATCTTACTACTCGGGTGTTGTAGCTGAAATACCCAATCCAGTCAATAATTATAGATACCTAGTATTCTTCGACGACGGCTACGCTCAATACGTCCAACACCAGTTCACCCGTCTAGTCTGCGAAAGTTCTCCCTTAGTATGGGAGGAAGTACATCCATTCTCGCGGGAATTCGTCCGCAAGTACCTAACGGAGTATCCAGAGAGACCGATGGTCAGGCTGCATGAGGGGCAGCATCTGAAGACTGAGTGGAACGGAAAATGGTGGTCATCCCGAGTGACCCGCGTGGACGCGTCGCTGGCGCAGGTGATGTTCGTGGGCGACGGGCGGCGCGAGTGGATCTATCGCGGATCCACGCGCCTCGCGCCTCTCTACCTCGAGCTGCGCGCCGCTGAACGACACCGACCCAGACCCATGCCTAGGAGCAAGGCGCAGCCTAGGTTCAATATGCCGTACGTAGAGTACACTCGGTCGGATGAGCAGGAGTCGAACAAGCAAGTGGATGCGCAGGCGCAGCAGCAACAACAACAGCAGCAGCAGCAGATACAAAATGAGGAGATACGTCGCCAACGCGCCGTAGCTAAGAAGTCTACCTCAGCACCTCCCCAAGTGCTCCCGCCATCACAACAGGTTGCGCCCACCCACTTGGATACCGTCACCAGCAGAGTTGTGTACTACACACCAAAGAACGCGGTGAAACCGTTGAAAATGGTGCCACACAGGTGTGGTCCGAGATGCAAGCGAAGCGACGTACTCTCACTAAAGGAATTGAGAACTTATAATCCTCTGGCTAAACCACTGCTCAGCGGATGGGAAAGACAAATTGTCCGCTTCAAAGGCCACAAGGAAGTGATGTACCGCGCGCCCTGCGGCCGCCGCTTACGCAACATGCGCGAGTTACATCAGTACTTACGATCTATAGACAGTGACTTGCCTGTAGACCTGTTTGATTTCCACTACTCTACGCATTGTCTGGCCGAGTTCGTGCTGAACAAGTGTTTAGTTGGGAAAAAGGACCTCTCCCACGGCAAAGAGAACGTCCCAGTACCCTGCGTGAACTACTACGACGACTCCTTACCGGAGTTCTGTTCGTACAACACCGAACGCACTCCCACGGCCGGTGTGCCACTCAACCTGGAGCCCGAGTTCCTGTGCGGTTGCGACTGTACTGATGACTGCCAGGATAAATCAAAATGCGCTTGTTGGAAAATGACGCTAGAGGGCGCTCGCACCATCGGGCTACGTGGACCTAATTTGGGCTATGTTTATAAGAGACTGCCTGAACCGTTACCTTCTGGGATATACGAGTGCAATTCTAGGTGTAAATGCAAGCATACATGTTTAAATCGAGTGGCTCAGCATCCACTACAATTAAAATTACAAGTTTTCAAAACTCCGAACCGCGGTTGGGGTATCCGCGCGCTGAACGACGTGCCCAAAGGCTCCTTCCTATGTGTGTACGCTGGGAATCTGCTCACTGATGCTACGGCTAACTTGGACGGTTTGAACGAGGGCGACGAATATCTAGCAGAATTAGATTACATAGAAGTTGTAGAACAGATGAAGGAGGGCTATGAAGAGGACATTCCTGAGGCCGACAAGAAATTAGACAAGAAAGAAAGTAGGGAAGGTGACGACAGTGACGAGGATGAGCCGTCATCCTCCGACGATGAGGAGACGGCTGATAAAACTGACAAGGAAGATGATGACTTCAGACCGGGATACATTGGACTTGGCGTTACAGAGTTCAGCAAACGCCTCCGTAAACGCGAAAAATCAAAGAAAGATAAAGAAAATGCGGCGGGTGATGAGAAAGAAAAGGACAAAGATACGACTAAAGATACAACTAAAGATACGGCCAAAGATACGACTAAAGAACCGAATGCTGAAGAGGATTGTATTACTATCAGTGATGATGAAGAAGTACGAGAACCTTCAAGATTCATGGCGCAAGCAAACATGGGAGCTAACGAATATATATCTAAATACAAGTCTGTTCGCACGTTATTCGGTAAGGACGAGGCGTGCTATATCATGGACGCTAAGGTTCAAGGCAACATTGGCAGATATCTCAATCACTCCTGCTGCCCGAATGTCTTTGTACAAAACGTGTTCGTGGACACCCACGACCCTCGCTTCCCCTGGGTGGCGTTCTTTGCACTCTCACACATAAAAGCGGGCACCGAGCTCACCTGGAACTACAACTATGACGTGGGTTCGGTTCCCGGGAAGATACTTTACTGTCATTGTGGAGCTGCTAACTGTAGGGGACGACTGTTGTAA
Protein Sequence
MTALELEKARETSKCINYCCTSDNKVPYKLAEPSVVAYYDAGRKRRSMVCQPCADVVTARSQNLIQGIKDLTPLIDLDMDKLSQDLVEISDSESEDEVTSTEEPKESIGEKGAQFIEENLAKYLNDTWKKYDMDTRLKETQIMLDDEIEKLEQDSKEIDAMLNECQIATDKLRCELYATFECRRENLPSLVIYDTPDSKTRQAKRRLSSQSETTPAKRPAIPLGYAPLDGGYSKEKAAVPAPDNKLDDDKDISVVKLSAEAAPADLPPPGEISRPPLRVGMPVYAMKNAFGPWLKGRVVEIQPKNTSGGNPFSVCLVKFDHKVKTNGKVLHARCIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQFTRLVCESSPLVWEEVHPFSREFVRKYLTEYPERPMVRLHEGQHLKTEWNGKWWSSRVTRVDASLAQVMFVGDGRREWIYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRFNMPYVEYTRSDEQESNKQVDAQAQQQQQQQQQQIQNEEIRRQRAVAKKSTSAPPQVLPPSQQVAPTHLDTVTSRVVYYTPKNAVKPLKMVPHRCGPRCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRFKGHKEVMYRAPCGRRLRNMRELHQYLRSIDSDLPVDLFDFHYSTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLRGPNLGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTPNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPEADKKLDKKESREGDDSDEDEPSSSDDEETADKTDKEDDDFRPGYIGLGVTEFSKRLRKREKSKKDKENAAGDEKEKDKDTTKDTTKDTAKDTTKEPNAEEDCITISDDEEVREPSRFMAQANMGANEYISKYKSVRTLFGKDEACYIMDAKVQGNIGRYLNHSCCPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKILYCHCGAANCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00124298; iTF_01377495;
90% Identity
iTF_00237602;
80% Identity
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