Basic Information

Gene Symbol
-
Assembly
GCA_949629185.1
Location
OX451379.1:2671150-2705612[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 2.3 2.1e+02 3.7 0.9 2 23 490 511 489 511 0.90
2 18 0.0025 0.23 13.0 0.0 1 23 521 544 521 544 0.95
3 18 0.0094 0.85 11.2 2.3 2 21 669 688 669 689 0.94
4 18 0.048 4.4 9.0 3.8 2 23 750 771 749 771 0.95
5 18 1 94 4.8 0.7 1 23 783 807 783 807 0.91
6 18 0.00018 0.016 16.6 0.3 2 23 814 837 813 837 0.97
7 18 0.3 27 6.5 0.4 1 23 843 865 843 865 0.93
8 18 0.0046 0.42 12.2 2.9 1 23 871 893 871 893 0.98
9 18 0.71 64 5.3 0.5 2 20 904 922 904 924 0.90
10 18 0.053 4.8 8.8 0.2 1 23 1003 1025 1003 1025 0.97
11 18 2.8 2.5e+02 3.4 7.2 1 23 1032 1054 1032 1054 0.95
12 18 0.0019 0.17 13.4 1.8 1 23 1098 1121 1098 1121 0.95
13 18 0.00066 0.06 14.8 0.5 1 23 1128 1151 1128 1151 0.98
14 18 0.0052 0.47 12.0 0.2 2 23 1173 1195 1172 1195 0.96
15 18 0.031 2.8 9.6 5.2 3 23 1221 1242 1220 1242 0.95
16 18 0.00041 0.037 15.5 1.2 1 23 1267 1289 1267 1289 0.96
17 18 0.00016 0.015 16.7 0.1 1 23 1295 1317 1295 1317 0.97
18 18 0.00052 0.047 15.1 0.7 3 23 1325 1346 1323 1346 0.95

Sequence Information

Coding Sequence
ATGACGGAGCCGCAACCACCATTGATCCTCTGCATGGAGAATGCGTCGGGTGAGGACGTGGCGCTCAGGATAGAACCAGATGATAACTTCCAGATGTTTCTGGATAAGGCCAGGTCACTCCTAGGCTTCGATGTAGACATAAACTCGATAACCAGAAACCAGCCCGTTTCATTATCAGAAAATGTCTACCAATTCCTAGTAAACGCTGAACAAAACTTACAAGCAGACGAGCTAACACAAAACTTTGACCAAATGTTGGACCCCAACGATGGAGCCAACGACTTGGTCTACATATTGGACGATGGCACACAAATCCGTGCCTCACAAATACACTTCGACAATGATGATCCTTTAGTTGATTTGACTGCTGagaaaataccttttgttaaatACGCTGAAGATGTCACTGACGTAGATGTTGATGATATAAATATTCACGAAACTaagaaaattaatattgttgaaaGTCCTGTGTCCAGATGGTCAAGTAATAACTCTAGCCCAAAATGCAGTTTTGTCAACTCTCTTCCATTCAAATTAGTGTGCAATAATACTTCGGGTTTCGAAGCTCAATTCACGAAATATTTAGAAGCGAATACAACAAAAACCTACGCGACCCTAAACCCTGTGACAACTCGAAATAAATCTCCGAAAAGTTTGATCaaagataattttaagaactacGATGATAACTATCAGAGGAATGACAACTTGTCGTACACTCGGGAGGAGATTTTGAACATGTTCAAAGACTCCCCGATGACGTCACTGCCGTATGACCAGGGTTACAGTGAGAGGAGACATGTTCGGAAGACGGATCCTTCGAGACTTGTTCATAAGAGTTGGAGTAAGCCTCTTTCTTACGTCGACATTGATGGGGTATTGATCGGAGAGAGCGAGAGCCAAATCTgttttatttgcggcaaacatgtggATAACAATGTTGATAAATTGTACCTTTTTGATAACGAAGATCAGAGGTTATATCGGTGTTCTCCGCAGAAGAAAATGTCAACTCAGCTAAAAATTATCTGCGAGTGTTGTCTTAACGAAAACTTCACTCCATGTAGAATGAAAAGCGCAAATCAATTCTTGAATCCTGATGAATACCTCGTGATCAGAAACAATCAGCAATATATCTTccagaaagttaaaaacttCAATTTCGCGCACCTAGGTAAAGCTAAAGAAATCATAAACAAGATAGAGAAGAAAATAGACAAGGAAGAGTTTGTTAAAGTCGAAATTGGCTCTGATGGAGAAATTATTACCAAGCCCATAGACACTAGGTCTGatgacattattattgttaaagatGAGAAGAAGGAGGGCAGTTCGAGTGACGTAGAGATTGTAGAGCCGGAACCAGAGATAGATAATATCATAGACAATTTGGAGGAAGCTGATGAGGAGGTGAAGGAGTTTTTGGGGAAATATCAACGCGATGATACTGAAGTTACTGAGTTAAAATGcagATTCTGTGAGCAAATCTTCTCTGATCTGGCGGCAGTGACGGATCACTGTGAAACGCACAAACATGACCTAGAAGATGGAGAAGTATTTCCTTGTCCACTCTGCAATTATGGTTATGCAAATTTAAAATGGCTGAAAGCTCATGTGAAGGCGGCTCACGAGAAGACAGAGACCCTTAAAGTATTAAAAGAAGAAAATGAACCAGTTAAAGAGGAGAGTAAAGATGACGAAgagataaaaacaaaagcatcATCACCCATTGCGACTCGTACTAGAAGTTCTATTAAAAAGGGAGATGGCGATAGAAAAGACGATGAGAAGTCGGATGAAGTTAAGGCTGATTCTAAAACTGAGGTGACGGAGCCACCCGTCATAAAAACGGAGGTAAAGCAAGAATGCCTGGACAGCAGTGAGGATGAGATCTGGATCGTTCAGACTGCTGATGCCGAAGCCACACAGGAGCTGCAGAAACTACTCTGTAGTGCCAAGGTTAAAGAAGATGGGCAAGATGGTGAATCTGAAAAGACACCTAAATGTTTTCATTGCGGCCAGATATTCACGAACGCAGATGGGCTGTCAAGCCATCGCTGTAGAAGACGCAACCGGAAGCGGAAGTCCAAGGACAACCTCATATGTATACCTACTGAGGAAGACTTCTTGAAGAGAGCTCAGGGTCGCCCTCGGCCAGGTGATACGTCAATAGACAGTGATCTTCTTACTATGCGGCCTCGTAAACGCCGCAGCCGGGAACCGACCTCCAACCCTCAGGTGGTGACTTGCCACAACTGTAATGAGTCCTTCACGTCCAAAGTTAGACTCAAGTTTcatatGCAGTTCCACGAAACATCAAACCAAGCCCGGTCAGACGGGCGCTACTCCTGCTCCGAGTGTGACGACGCCACCTTCGCCACGGAGACGGAGCTCTTCGACCACGTGCACTTCCAGCACGACAAGCAGAAGAGGTGGCAGTGTCCCGTCGAGGGCTGCGGGAAGACCTTCTTCCTCAGgGCAACCCTAACAAAGCACAGTCGCACGCACACAGACACACGACGATATGTGTGCGTGACATGTAACAAGCGGTTTTTAGACAAACAGACGCTAGATGAACATGGAGTGACGCATTTACAGATAAAACCCTTCCAATGCCACATATGCCTGAAGCAGTTAACCCGTCGCTCGCGCTTGCGTATGCATGTGCGCGCGCACGAAGAGGAGTTGTCGCCGAGGCTTGTGCGCGTCTGTGCGGTCTGCACGAGGGCCTTTAGAGATCATCGGCATGCACAGGAGCACGCCTCAAAGTCAACAGAATGTATCGAAGCTTTCGCAAACGAATTAAAAGAGGAAGCGGAAGAGGTGTCAGTACAGTTGTCGCCTACCAGTGGACTTGTCAGACATGCTGTGCAGATAATTGAATCTCCGAAGCTATCAAAGCCCATCAAACGCCAAGTGTCGAATGAAATGGGCGAGCACCTCCTGTCTCAGTTAGCTGACGAAGCGCGCGCTCTGATAAGGGTGGTCGAGATTGAGAAGGCGTTCCGCTGCGAATATTGTGAAGATGTTTTCTATTTGGAAAGTGGTCTGAATACCCATCGTGCGATACACAAAGGAGTCAAAAATCCCTTCACCTGCCACATCTGTAAAGTTAGCTTCGCTACTTATTCCAGATGCACAACCCACAAAACAACCCACGGCTTCTACAAACGCTCGCTAGCCGACGCTAAGAAGCAAGCCGACGGTCCCGCACAAGCTGATGCCGACTCCTCCGCCCGCTCTGCCACCGGCATTCTGGGATACGGCGATTTTCCTGTCGTCAAACACTTCCTATGCGAGGACTGCGGCCGCTCGTACCTACACTGGACGTACCTACAAGTACACAGACGCATGAAACACGCGAATGAAAACTTTCTGTACAAATGTAACCAGTGCGAACTTACCTTTCCAAACAGTTGGGGCCTGGCGTATCATCGTAAGAAGGTGCACGGCAAGTCTGGAGCTGACGACCCTGGAACCACCAACAAGAGCAACAGGGATGATTATAGGATACCGTGTCGGGATTGTGACGAGGTGTTGCCCAACAAAACAGCTTTGTACAAGCATCGTAAGAAAGAACACAGCGATGGAACTGCTCGAGCTTATACTAAACCAGGCATGTATGCGAGTGCAGAGTCAGGATCCACAGGCGGAGCGTGTTCCCATTGTCACGCCACGTTCACGCACGCGATTGATCTGCACAAACACGTCAAAGAAGTCCACGGCAAAGACGATGACTCCTGCCTATCCTGCAACAATACATCGACCACGGAGGGGACATGTCCGCGCCGGCCGCACGCGTGTCCCGTCTGCGGACACGCCTTCCGGACACTATCTATGCGGAACGAACATCTGAGGGTACACACAGGGGAGAGACCCTTTCCTTGTGACGTTTGCGGAGTTGCGTTCAGGAGGTCCACAGCCATGCGCAACCACCGCCTCATCCACACGGGCGTGCGCGCGTGGGCGTGCGGGCGCTGCCCCAAGCGCTTCCGCATCCGCTCCGACCTGCGCACGCACCTGCGGCTCAAGCATCCCGCCACCATTGTCGTTGTAGAGatGGAAGGCCTGAACCCGTCGTCTGAGGAAGTACTGAAGGCGCTCGCTGCACAAAACGTTCCTCACGACAAGCTTATAGATATCACTAAGATGTCCTTCGCAAAGGGCTCAACGAGCGTGATACCTTCGTGCGCACGCGCACTGTCAGCCCTGAACAACGTGCCGCGCACACACGTCGCGTGCATCAAACCTACGCCCGCACTGGAAGAATTTCAACCGGCCCGTCGAGGTCGCGGCATCGCTAAAAACCCGCGACGACCCAAGATACTGCAGCGAGGCGAGGTGGAGCCACACGACAACTCTGCCTACCCTATCGTTGGTGGAGAGGAGCTGTCAGATCTGAACGTGCAACTCCTACTGCGGGATGGCGTGCTAGTCAACGGGAACCAGATGGTCCAGCTTCAGTTAGACGACCCTATTCTGATGGAGTAG
Protein Sequence
MTEPQPPLILCMENASGEDVALRIEPDDNFQMFLDKARSLLGFDVDINSITRNQPVSLSENVYQFLVNAEQNLQADELTQNFDQMLDPNDGANDLVYILDDGTQIRASQIHFDNDDPLVDLTAEKIPFVKYAEDVTDVDVDDINIHETKKINIVESPVSRWSSNNSSPKCSFVNSLPFKLVCNNTSGFEAQFTKYLEANTTKTYATLNPVTTRNKSPKSLIKDNFKNYDDNYQRNDNLSYTREEILNMFKDSPMTSLPYDQGYSERRHVRKTDPSRLVHKSWSKPLSYVDIDGVLIGESESQICFICGKHVDNNVDKLYLFDNEDQRLYRCSPQKKMSTQLKIICECCLNENFTPCRMKSANQFLNPDEYLVIRNNQQYIFQKVKNFNFAHLGKAKEIINKIEKKIDKEEFVKVEIGSDGEIITKPIDTRSDDIIIVKDEKKEGSSSDVEIVEPEPEIDNIIDNLEEADEEVKEFLGKYQRDDTEVTELKCRFCEQIFSDLAAVTDHCETHKHDLEDGEVFPCPLCNYGYANLKWLKAHVKAAHEKTETLKVLKEENEPVKEESKDDEEIKTKASSPIATRTRSSIKKGDGDRKDDEKSDEVKADSKTEVTEPPVIKTEVKQECLDSSEDEIWIVQTADAEATQELQKLLCSAKVKEDGQDGESEKTPKCFHCGQIFTNADGLSSHRCRRRNRKRKSKDNLICIPTEEDFLKRAQGRPRPGDTSIDSDLLTMRPRKRRSREPTSNPQVVTCHNCNESFTSKVRLKFHMQFHETSNQARSDGRYSCSECDDATFATETELFDHVHFQHDKQKRWQCPVEGCGKTFFLRATLTKHSRTHTDTRRYVCVTCNKRFLDKQTLDEHGVTHLQIKPFQCHICLKQLTRRSRLRMHVRAHEEELSPRLVRVCAVCTRAFRDHRHAQEHASKSTECIEAFANELKEEAEEVSVQLSPTSGLVRHAVQIIESPKLSKPIKRQVSNEMGEHLLSQLADEARALIRVVEIEKAFRCEYCEDVFYLESGLNTHRAIHKGVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRSLADAKKQADGPAQADADSSARSATGILGYGDFPVVKHFLCEDCGRSYLHWTYLQVHRRMKHANENFLYKCNQCELTFPNSWGLAYHRKKVHGKSGADDPGTTNKSNRDDYRIPCRDCDEVLPNKTALYKHRKKEHSDGTARAYTKPGMYASAESGSTGGACSHCHATFTHAIDLHKHVKEVHGKDDDSCLSCNNTSTTEGTCPRRPHACPVCGHAFRTLSMRNEHLRVHTGERPFPCDVCGVAFRRSTAMRNHRLIHTGVRAWACGRCPKRFRIRSDLRTHLRLKHPATIVVVEMEGLNPSSEEVLKALAAQNVPHDKLIDITKMSFAKGSTSVIPSCARALSALNNVPRTHVACIKPTPALEEFQPARRGRGIAKNPRRPKILQRGEVEPHDNSAYPIVGGEELSDLNVQLLLRDGVLVNGNQMVQLQLDDPILME

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00121732;
90% Identity
iTF_01247427;
80% Identity
-