Basic Information

Gene Symbol
-
Assembly
GCA_951804975.1
Location
OX638119.1:9829672-9839232[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 29 7e-06 0.0035 20.3 1.0 1 23 218 240 218 240 0.98
2 29 0.01 5.1 10.4 3.7 1 23 263 286 263 286 0.96
3 29 9.3e-05 0.047 16.8 0.8 2 23 293 315 292 315 0.96
4 29 0.056 28 8.0 0.5 2 21 337 356 336 357 0.92
5 29 0.0083 4.2 10.6 0.0 2 23 453 474 452 474 0.94
6 29 0.0042 2.1 11.6 0.6 2 23 481 503 480 503 0.91
7 29 0.00013 0.067 16.3 0.1 1 23 570 593 570 593 0.96
8 29 0.026 13 9.1 0.4 1 23 599 622 599 622 0.96
9 29 0.07 35 7.7 0.8 1 23 635 657 635 657 0.97
10 29 4e-05 0.02 17.9 0.9 3 23 701 722 700 722 0.96
11 29 0.0014 0.72 13.1 0.9 2 23 782 805 781 805 0.95
12 29 3.5 1.8e+03 2.4 0.0 2 23 814 836 814 836 0.84
13 29 0.098 49 7.3 0.1 2 23 843 865 842 865 0.95
14 29 1.5e-05 0.0074 19.3 1.2 1 23 873 895 873 895 0.98
15 29 1.1 5.7e+02 3.9 0.6 8 23 929 945 921 945 0.83
16 29 0.00024 0.12 15.5 3.3 1 23 948 971 948 971 0.97
17 29 0.00047 0.24 14.6 0.3 2 23 978 1000 977 1000 0.96
18 29 0.001 0.52 13.5 3.9 1 21 1024 1044 1024 1045 0.95
19 29 0.003 1.5 12.0 1.8 2 23 1059 1080 1058 1081 0.93
20 29 0.49 2.5e+02 5.1 1.4 1 23 1084 1107 1084 1107 0.94
21 29 0.013 6.8 10.0 1.0 2 23 1114 1137 1113 1137 0.92
22 29 3.4 1.7e+03 2.4 0.2 2 23 1145 1167 1145 1167 0.94
23 29 0.25 1.3e+02 6.0 2.7 2 23 1205 1227 1205 1227 0.96
24 29 1.9 9.8e+02 3.2 0.1 2 23 1233 1255 1233 1255 0.95
25 29 8.3e-05 0.042 16.9 0.2 1 23 1318 1341 1318 1341 0.96
26 29 0.1 51 7.2 3.5 1 20 1366 1385 1366 1387 0.93
27 29 0.56 2.8e+02 4.9 1.3 2 23 1484 1506 1483 1506 0.94
28 29 0.27 1.4e+02 5.9 0.2 2 23 1513 1535 1512 1535 0.94
29 29 5.4 2.7e+03 1.8 2.6 1 23 1546 1568 1546 1568 0.92

Sequence Information

Coding Sequence
ATGGAGCCCAGGGAACGCTATCAGGAGCTCTGCAGACTTTGCGCATCCTACGACGCCGTCAAGATGGACATCTTCGGTCAAGAGGGCAAGAACAGACAGCTCGTTGACAAGATACAAGCTTGTCTGCCGTTTAAGATTGCAGAAGATGATCGACTACCAAAATGCCTGTGTTACCGCTGTATGtacaatttggaaaatttctatGATTTTAGAACAGCATGTGTTAATGCAGTGGCCCTTTTGGAAAGATGTTTACCACCTTCGGAATtgaaTGGAGATGTTACATCTACATTGACATATCGCAATGATTCAGAGCTCTTTAAGGGAAAAGGGAGTATACCAGTATTGATTCCAGAGGCTCCTATTGTGAATCCAAATGCTGCCTTAGGCACACCACCCAGATTAAATTCTGATGGGGAAGCTGATCATGAGACAGAAGAAATTGTTGATAACAGTGGTACAGATGAAGCAACGATAATAGATGATTCCGAAGATCGACATTCGGAAGAGTATGAAATGGATATGGAGACAAATCCAAGTGACTTTTTAGAAATGACTTCAATGGTTACAGAAGAACCAGAAGAATCAGAATTAAGACATCAAGAACTTTCCAGTAATTTATCAGAGCATACATCTCAACAACATGAAGTATATGTTTGTTCATTGTGTAACAAAGCATTTAGTTCAAAAGGTCATTTATCTTTACATGCACGTATTCACGTGGGCGCTGGTGATGTGATTGGTGAAAAAGTTCTTACAGATGATCATACATCTTATAAAAGACCCTATCAATGTGATCTTTGTCATAAATCATATTCCACAGCGAAACATCGTTGGGGTCATGTTTCTACAACTCACAgAGGCCACCCGGCAGTGACCTGCAGTTACTGTTCCCGGATCTACTCAACCCGAACAAATTTAGAGGAACATATAAAATCACGTCACGCTGGCCTTCCAGCACCTACAGAGGTTCTAATGAATAACATCTACCGTCCAGAGAACAGATGTCAGTGTAGTGCATGCGGAAAGATTTGCACGGATGCCATGGAACTGAATCTTCATGGTAGGATTTGTTCTGAAGGACAGAGATTGGACAATCCAGTGAAAAGTGAGAGTAGGGATAACAAACTCGTGGAGAGTTCTGAAGCTTCAAGTATCGGTAGCGATGACGATGGCAAAGATTATAGAACTGCAGAAGCTAAATTAGCCAAGAATCCTCAACTGACAATTCTAAAACAAGCATTAACGAAAGGAGACAGCCTTAAGCGAGATTTTGAAGACAAGTTTACAACAAATTGCAAACCTCAAAAACTACCGAAAACAGAAAATACTAATATTCAAAACATTAAAAAGTGGTACTGTGAATCTTGTCCTCAGTCTTTTACTTCAATTGAGGATTTGAAAGAGCATGAAGCTGTTCATGATGCTGATAAGCCATTCATTTGTATTCTATGTAAAAAAGATTTTGTCCTGAAGTCTTCCTTAAGCAGGCATATTCAAACATTACACGGCGTTGATCCGTTACCCATAGTAGAAAGTGATAAATGTCTAAAAAAGATTGTTTCACAAAATTGGAATGAATCCATGGAGATTGATTTGTACGAAGGTAAAACATCTTCCGAATTTCCTTTATCTCCAGAGATAAATGCAGAAAATGAAGATGATCCTGAGAGTGGGCAAGAAAATCTCATTGAAATTGAAActgtattcgtctgtgagatttgTACTCGTGATTTTAACGATCGCGCGTCACTTTGGCTTCATATCAGAGCTACTCATAAAGAATTTGCGGCATTCGCGTGTggcgtttgtttaaaaatttgcgCGGATAATACGCAACTTTTGAATCATGTAAATATGTACCACGGCGGTTCAAAATTACTACTCTCTGAACAAAGAAgGTATAGTTGTACCATTTGTGGCAGACAACATGATTCTAGGAAAAAGTTAATTGCACACGTGTCTATACATAACGTGGATCCGAATTATGATCCTGCAACTTTTGTTCAGTTGAACAGTAATTATTATGGTGAGAATATTAACGGCAATGAAACTGCAGAACAAATGCTCGATTATGAAGAAGATGGAGATAAAGTGGATTgttatatttgttataaatCATTTCCTAACGAAGATCATTTAATACGACATCAAAGAAATGCACATAGGTCTGAACAACTAGTGCCAACAGGGGATTCTTTAAATTCATCGAGTTTAAACGGTGGTGGAAACAGAGCTCAGTATCATCTCTTTTTCGTTTGTGAACTTTGTGGTAGTTCACATCCTAGTAAATGGGAACGTTGGTTACATGTTAGTTCTTCCCATAGTAATGAACCAGCTATAAAGTGTGACCGTGAAGACTGTGGTAAAATATTTGCTACAAAATCTCTTAGAAACGAACATATTCAACATCATGCAATTCAAGGTTCATCCCCAAATACATGTGAAATTTGTGGTAAACTTTGGGGCAGTAGAGTTGATTATTGGAAGCATGTCATGGGTGTTCATTCGGATACTGTTCCATTGATCTGCGGCGTCTGTCTCAAAGTGTTCCCGAATGTTTTACAATTGAGTACTCATGTCAAGTCAAAGCATTGGCCGTTAACAAATGGTGATTTTAGTTGTGACATTTGTGGTAGACCGTATTCGAATAAATCTAAAATGTCCAGACACAGAAAAATTCATGGTTTTGAAGAGAGTTGCGACAATGGAGcagagaataatgaaaataaagttGATGGACGAACGAGGGAAACTGAATTAAATTGCGAACTCTGTGCAGACTTGATGTTTACCAGtttagaaaaattatgtaatcATAGACGAATTGTTCACGGACTTTTCCCTTGTGATCTTTGCAATAAATGTTACGGAAGAACTTCACATCTGTGGAAACACGTGAATAGAGTTCACAAAGGTCACGAAGATGTAACTTGCCCCTATTGCTTGAAAACTAGTGCTTCAAAGGATCATTTAGCAGCGCACATTTCAAAAATTCACAGATACGAACCTGATTCCAGAAAAGACGGGAAAGATAATAGACAGTTTAAAACTGAGGAAGTTAGTTTGCATTATTGCGAGAAATGTAATAAAGGATTTCATAAACGATATCTTTTACGTAGACATATGAAAGGATGTCAGAATTACAGGAAAGATCCTGGAGCATTGTTAACAAGATGTAGAGCTTGTGAAAGAATATTCAAAGATCGCGCTAGTTTACAAAAACACATTGAGAATCATCATAGTACATATACGTGTCATCTTTGTAACGAGACAATTACATCGAAACTAGGAATTATGACGCATAATAGGGTGAAACACATGGATCATCCAGATTTAACTTGTAATTTTGGATCTTGTAAGAAGTTGTTCAGAACTAAGGAAGATTTGGAAGCCCATAAAAAGGATCACAGgTATCATACAACTCCCAATGTCTGTGACTTCTGCGGCGATACTGTTGAAAATaaactgaaattaaaaatgCACGTGTTGTCTCTTCATCGTAACGAAATTGGCGTATCTTGCGGAGTTTGTTTAATTCCAATGAAGGATCCGAAAGAGCTTAAAGGTCACGTGGAGGAAGTCCATTCCGGTGTCCTCTCGAGACCTAATACATGTCAAGTTTGTGGGAAACAGTATGCCTCAAAATGGAAAGCTTTCGATCATACTAAAAAGTGTCATGGGAAGGTATTCAGGACTTGTAAACAATGTTTAGCTGTTTTCACTGAAGATTCTGCAATTCGTGATCATTATGAAACAGTACATAATATTCCCAAAGATCAGCTTGCTGCATTTGAATACAGATTAGATATCAGGTCGAAAAATGAAGATTTCGAAGTGGGGTCTCCTGATGTAATAGTTAAAGAAGAACCGGAAGATTTGGAATACGATGTAGATATCTGCGATGAGGATTCTAGCGATTCGAAAAGGAGAAGATCTTTAACAGATACTTTTGACTGTGAAATGTGTCCTGAAATGTTCGTGAACAGCGATGCACTTTCAAAACATTATCGGAACATGCATAATACAGATCCAGAAAGAATGTTCAAAAGATTAAAACAAGACGAACAGAGAAGAATGCGTGGAAAAATGAACTTCTTCTGTAAGAATTGCAAAAGACAGTTTTGCACAAAAACGTTGTATTGGAATCATGTGGCAAATTGTAGAAGGAATATTATGCGAAAAGAAGAAGAACTTCTACCTTTGCAAACCGACGTGTTAAGTAATCGAGAggaacttttgaaaaataataatcaaattaaGAAAGAAGAACCTACatcgaatttgaatattcctGATTTTAATCTCTTTGAAGATATAAATCTCCAACTGTCGGGTCAGAGACCTCTTCCAAATCTTATGCCACTCTCTCAGAgAACGAAATCATCGATAAAATGTTCAAGAAAGGATTCCAGGAAAGTGTATGACGAATCAACGAATACAGAATGCGCTTGTGAAGTGTGTGGAAAACAGTGGCCAGCGAAAAAACACTTATGGCAACATTTGATTCGTTTCCACCGAGCGGAAGCAGCGGTTACTTGTGGCGTATGTCTGAAACTTTGCAAGGATTACGATGATTTGGCAATCCATCTAAAAGCTGCTCATGAAGCGATACTTTCATGCGAAGGAAACAATTTTACGTGTAAAACTTGTGGCAGGTATCATAATGCACGTAGTAAATTGTTACTACATACAAGTATTCACATTGGACATGCAGGTAACAGTACTTGGTGTCCAAAGTGTAGGAAAAATATTACCGATGAAGCTTCTCATGCAAACACATGTCTTGGGAAAACAGAAGACGAAGAACcattgaaaaataatgaaaaagtagAAGAACGATTAATAGCGGACGATACAATGatcgaagaagtagaagaaggagATTTTGAATCAGAAGCAGAAGAAGGAGACACAGAAGAATCGGAAAGTGGAAGTAGTACCGAAGTTGAGGAAGAAAATGAATCAGAGGGTGAATCTAGAGCAACGGAAGAAATTACTTATAATTCAGAAAGTGAAGATTCTGAAGTATTAAATTTGGAGATCGACGAAAAGAGCATGCAGCGTTATACTCTGGAACACCTTCAGGAGACTAAAAATGCAGAAACGGTAAAAAATACGGATGTATCGGATGACGATGGACCTCCAGTTCTCAGTCCTATAATGCCTTTGCTCGCTGAAAATATGTCTGTGGAACAGTCATTGGGACATAAACTTGTTTCTATTGTATCTTTAAGTGGGAAAGAAATGCAAATGcgtaatctgtcagaagttcggAAGCAGTCTTCTCCAAAATCGGTGAATCTATACGAAAAACGTTTATTGAATAACGAATCTTTAGACTTTGAATCGGAAACGTTTGTAAATCGAAGCGACGAAGATTTTGAAGATACGAAAAATGAATTCGATGAAAATTCTATTGAAGAAAATGAAGATAACGAAGAGATCGAAGAAAATGAATCGGAGAATGAAGAAAATGTGGAAACTGAGCATGAAGGGACTCGATTTCTgaagaaaggaaatgaaaatggagaggttgaagaaattgaagaaaattacgGCATTGAATTAAACGAAGAGATGGAagagaataatgaagatatcgAAGAAGAGAACGAAGAACACGGAGAACTTGAAGATAcagaagaaaacgaaggaaacgaagatattgaggtGAGCGACAATAAAGATAATGAAGAAAACAGCGAGATGGGTGAGCACGAAGAAAATGATGAAATCGACGATAATGAGAATAACGAAGGTATCGAAGAAgttgaagaaaacgaagaaaatgaagaatttgAAGGAACATTAGAAAACGAAAGGAATGAAGAAATTGATCAGGTGAACGTCAATAAAAGCCTCGACGAAATCGATGAGATGGATGAGATGGATGAGCACGAAGGAAATGATGATATTGAAGAAACAGAGGAAAGTGAAGGGAATGAAGAAACCGAAGAGAGGGAAGATAACATGCAACTGGATGATCTAGAAGGTGCTGTTTTAATGGTAACCGAAGGAGATCAAATACTGATTCAGCAAGGAATATTGgaagatgaaaatgaaaattcaagtcAGGAATACGTTTACTCTACATTTACGTACAATACAgaggatagtgacgatgcaaggAAATGA
Protein Sequence
MEPRERYQELCRLCASYDAVKMDIFGQEGKNRQLVDKIQACLPFKIAEDDRLPKCLCYRCMYNLENFYDFRTACVNAVALLERCLPPSELNGDVTSTLTYRNDSELFKGKGSIPVLIPEAPIVNPNAALGTPPRLNSDGEADHETEEIVDNSGTDEATIIDDSEDRHSEEYEMDMETNPSDFLEMTSMVTEEPEESELRHQELSSNLSEHTSQQHEVYVCSLCNKAFSSKGHLSLHARIHVGAGDVIGEKVLTDDHTSYKRPYQCDLCHKSYSTAKHRWGHVSTTHRGHPAVTCSYCSRIYSTRTNLEEHIKSRHAGLPAPTEVLMNNIYRPENRCQCSACGKICTDAMELNLHGRICSEGQRLDNPVKSESRDNKLVESSEASSIGSDDDGKDYRTAEAKLAKNPQLTILKQALTKGDSLKRDFEDKFTTNCKPQKLPKTENTNIQNIKKWYCESCPQSFTSIEDLKEHEAVHDADKPFICILCKKDFVLKSSLSRHIQTLHGVDPLPIVESDKCLKKIVSQNWNESMEIDLYEGKTSSEFPLSPEINAENEDDPESGQENLIEIETVFVCEICTRDFNDRASLWLHIRATHKEFAAFACGVCLKICADNTQLLNHVNMYHGGSKLLLSEQRRYSCTICGRQHDSRKKLIAHVSIHNVDPNYDPATFVQLNSNYYGENINGNETAEQMLDYEEDGDKVDCYICYKSFPNEDHLIRHQRNAHRSEQLVPTGDSLNSSSLNGGGNRAQYHLFFVCELCGSSHPSKWERWLHVSSSHSNEPAIKCDREDCGKIFATKSLRNEHIQHHAIQGSSPNTCEICGKLWGSRVDYWKHVMGVHSDTVPLICGVCLKVFPNVLQLSTHVKSKHWPLTNGDFSCDICGRPYSNKSKMSRHRKIHGFEESCDNGAENNENKVDGRTRETELNCELCADLMFTSLEKLCNHRRIVHGLFPCDLCNKCYGRTSHLWKHVNRVHKGHEDVTCPYCLKTSASKDHLAAHISKIHRYEPDSRKDGKDNRQFKTEEVSLHYCEKCNKGFHKRYLLRRHMKGCQNYRKDPGALLTRCRACERIFKDRASLQKHIENHHSTYTCHLCNETITSKLGIMTHNRVKHMDHPDLTCNFGSCKKLFRTKEDLEAHKKDHRYHTTPNVCDFCGDTVENKLKLKMHVLSLHRNEIGVSCGVCLIPMKDPKELKGHVEEVHSGVLSRPNTCQVCGKQYASKWKAFDHTKKCHGKVFRTCKQCLAVFTEDSAIRDHYETVHNIPKDQLAAFEYRLDIRSKNEDFEVGSPDVIVKEEPEDLEYDVDICDEDSSDSKRRRSLTDTFDCEMCPEMFVNSDALSKHYRNMHNTDPERMFKRLKQDEQRRMRGKMNFFCKNCKRQFCTKTLYWNHVANCRRNIMRKEEELLPLQTDVLSNREELLKNNNQIKKEEPTSNLNIPDFNLFEDINLQLSGQRPLPNLMPLSQRTKSSIKCSRKDSRKVYDESTNTECACEVCGKQWPAKKHLWQHLIRFHRAEAAVTCGVCLKLCKDYDDLAIHLKAAHEAILSCEGNNFTCKTCGRYHNARSKLLLHTSIHIGHAGNSTWCPKCRKNITDEASHANTCLGKTEDEEPLKNNEKVEERLIADDTMIEEVEEGDFESEAEEGDTEESESGSSTEVEEENESEGESRATEEITYNSESEDSEVLNLEIDEKSMQRYTLEHLQETKNAETVKNTDVSDDDGPPVLSPIMPLLAENMSVEQSLGHKLVSIVSLSGKEMQMRNLSEVRKQSSPKSVNLYEKRLLNNESLDFESETFVNRSDEDFEDTKNEFDENSIEENEDNEEIEENESENEENVETEHEGTRFLKKGNENGEVEEIEENYGIELNEEMEENNEDIEEENEEHGELEDTEENEGNEDIEVSDNKDNEENSEMGEHEENDEIDDNENNEGIEEVEENEENEEFEGTLENERNEEIDQVNVNKSLDEIDEMDEMDEHEGNDDIEETEESEGNEETEEREDNMQLDDLEGAVLMVTEGDQILIQQGILEDENENSSQEYVYSTFTYNTEDSDDARK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00218574;
90% Identity
iTF_00761118;
80% Identity
-