Basic Information

Gene Symbol
Rreb1
Assembly
GCA_000390285.2
Location
NW:12412-58280[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 3.3e-05 0.001 19.1 0.7 1 23 81 103 81 103 0.99
2 16 0.00017 0.0053 16.9 0.3 1 23 116 138 116 138 0.98
3 16 9.8e-05 0.003 17.6 6.4 1 23 144 166 144 166 0.98
4 16 0.051 1.6 9.1 0.1 1 23 228 252 228 252 0.88
5 16 0.089 2.7 8.3 1.3 2 23 258 280 258 280 0.96
6 16 1.3 38 4.7 1.5 1 20 326 345 326 347 0.91
7 16 0.12 3.6 7.9 0.1 1 23 476 498 476 498 0.96
8 16 8e-05 0.0025 17.9 1.9 1 23 507 529 507 529 0.98
9 16 0.0014 0.042 14.0 3.1 1 23 535 558 535 558 0.97
10 16 0.0014 0.041 14.1 2.1 1 23 953 976 953 976 0.95
11 16 0.00081 0.025 14.8 0.4 2 23 1190 1211 1189 1211 0.97
12 16 0.21 6.3 7.2 6.3 1 23 1217 1240 1217 1240 0.97
13 16 0.069 2.1 8.7 1.1 1 20 1269 1289 1269 1290 0.94
14 16 0.14 4.3 7.7 0.9 1 23 1350 1373 1350 1373 0.96
15 16 0.027 0.84 9.9 0.4 3 23 1420 1440 1418 1440 0.93
16 16 0.012 0.38 11.0 5.9 1 23 1446 1468 1446 1468 0.98

Sequence Information

Coding Sequence
ATGCAAGGGGCCGTTTTTATGCCTCACAACCCCCAACAAGGCTTTCCGCCCCCAAGCGGCCCCATAGTTACCGAAATGGAGGCATCGCCCTCGCCCAACCAAATGACCAAAGAGGCCTTAGCCAATCGCAGCGATTCGGGTATTTTCTCGTCAACCACCAACACCACCATTGACCAAACCGACCTCTCCAAAAACTCCGATTCCGACAACAGGAGCGACTGCTCCTCGCCCGAAAGGAAGTACGTCTGTCCGATCTGCGACCGAATCCTAACATCCCAACACGAATTCACTCTACACATCCGGTCGCACAATAACGAAAACGAAGTGCAGGACACCGAAAAGGGCTACACCTGCAGGATATGCCAAAAGGTACTCAGCTCGAATAGCAGTCTGGACCGCCACGTCCTAGTGCACAGCGGCGAGCGTCCCTTCCACTGCAAATACTGCGGGGACACTTTTACCACCAACGGCAACATGCACAGACACATGAGGACGCATTCCCATAAGTCCGATAACAACTATGAGTCCGACGGAAGCGTGGACAGTAACAGTTCTAAGAGTACCGAGTTCAATAACAATAAGGTGGAAAAAGTGAACAGCAATAAAAGGAAAATCGACAGTCCGGACGGTAGCAGCAAAAGGCTACGAGACAACTGCAGCGACAGCGAAACATCGCAGTCGTACAGGTGTCCCGTATGCGAAAGATCGGACTTTAACACCTTGTCCAACCTGGAAGCCCACTTAGAAGACAATCACCCCGATTACCCCGCCAAGTGCAACCAATGCAATAATGTTTTCCTCAACAACAAGCAGCTGACGGCGCACAAAGCTACGAACCATGAAAATATCGTTTCCCGACACTCCGTGGTCGGTTTCAAGGACCTCACCTTCGTCGACTTTTCAAGCGAAAAGTTTCCCCACATCGCTCGAAGGGAATGTGAGTTGAACCTTCATAAGGTGTCTGGAGGGTTGAAGTTTCAATGCAGGAAATGCACCAGGGCATTCCCTTGCAACAACTCTCTAGAGATCCACGAGAAAAACTGCATTCCCGTAGAACACGCCAACGGCTTGGACCTCAGCACCATTTCCCAACCCGAAATTAGACGTATGGAATTCTTTTCCAGGCTCAACTTGCTAAACACATCTCCTGAGAAACAAGTTCTACCTCTTCAACAAAACAAAACTCCGAATAAGCTGCAGGAGCACCTAGCGAAAGCGATGGACAATACCAAAGACTTAGCAGATATCCAGTCTATCCTATCCAACATTAACCTGCAGCAACTCCAGGCTAAACAGGGTGAATTGAGGTTACCGACTTCAAAGTCACAAATGGAGCACTCTCCCGAGTTTCAGAAAAACGAACAAGAGGAGGAGTCCCAGGATCTGTTCGCCGTGGAGTTTAGAAAAATGAAGTTACGGGGAGAATTTCCTTGCAGGTTGTGCACCGCGGTGTTCCCCAATTTGCGAGCTCTGAAAGGGCACAATAGAGCCCACCTCAACGGGAATACCAACGGGACGTACCACTGTAACATGTGCCCTCATTCGTCCATCGATAAAGCGGCCTTGATCAGACACATGCGAACTCACAACGGAGACCGACCTTACGAATGCTCATTGTGCAACTACGCCTTTACCACCAAAGCTAACTGCGAAAGACATCTGAGGAATAGGCACGCCAAGACCACGAGAGAAGAAGTGAAAAAGTCTATAATCTACCATCCCTCGGAAGATCCTACCAACGATGACCTCAACAAATTGGCGGCAAAGGAAGaaccaaagaaattaaatataccGTCTTCTTCTGAAGCGAACGACTTACCTCCGGACAAAATGATATGCTCGACACCAAAGATTTCTGACGCCTTACGGAGCCACATGTCCGATATAAAGACGGACATGAACCTGCTTAAGCCCAATGTAACACCCTTGGTACAAGAGTTGCCCGTATTGAAGCCACAAAAGATTTTCCCGAATATTAACGACATCATTCGAAATGAAAATCTGAGATCGTTAAAGGAACATAAGATGTTACATAACGGAGTAGTACCTTTGTTACAGCCTAATTTTGGTTACACTCaacaaaaaattcaagtcaAAAGCTTAGAGGCTCTAAAAGAAAACGTCTACGACGAGTCCGAAGAGGAGTACGTCGAGGAAGAAGAGCAACCCATGGACCTAGTTTTGGATTTGAGCAAAAAGAAATGCGACGAGGATAGCAAGCGCCACCGAGAGGAATTACCTCAAGATTTAACCAAGAAAACGCCGCCACCACCAAGTCCTGTAACGCAATTACCACCTAATATGGGAGAGTTGTTCGCTCAGCAACTCCTTAAGACACCTCCAAAAATAGACCAGGCAGCCTTATACGCAACTCAGCTAGCCCACTTTTACCGTAGCGGCTTCCCAGCTTTGTCCAACTGGACTGGCTTTCCTTTGAACCCTTTGCTCTTTCCCGCTTTAGCTCCTACGTTGCCCCAAAATTCACAAGATCTTAAAGAACGCATGCAGAGGTTTCAGTTATGCGGTGGGTCCATGATAGCAGAGGATTTAAAAAACCTGCAGAATCTACAAAACCTACAGCAGCAATCGCTGCGAAGCCCTACGTCTAACTACAACGGATTTAAGATAGAACCCAAGCCGGAAATCAAACATTTGTCCACACCGAAAAAACCCGAGGACATGAAACCGCTAAGTTTGGACGTGGATACGAAATTTGTTGATAATACATCTAAAATGCAAAGTCCTATTCCGCAAATAAAAGACTTGATGCCGTCCCCTAATTCTGTAAAGATGGTGATAAAGAACGGAGTGCTGATGCCGAAACAGAAGCAGAGGAGATACAGGACGGAACGACCCTTCGCCTGCGAACACTGTTCGGCTAGATTCACACTGAGATCGAACATGGAACGGCACATTAAACAGCAGCATCCCCAATTTTGGTCTCAGCGCCAAAGAGGCAGCGTCGGAAATCCAGGCCGTAAGGCCCAGTCCCTGCCCATGAAGCCGAGCTATTGCGACCTCAGCATTCCAAACTATGAAGCAACGAGGTCGCACGAGTACAACGATACCAAAGAATTACTAAATGAAAAGATTAAACTAGCCATTTTAGAGCAGCAACTGAGAGCGAGTCAAAACGTTAATCAGGATGAAAAAAAGGACGAGGATGAGGACTGTGAACTGGTCATAGACGAGAACGAAGAGAAACCCGAACCAAAGACTGAAGAAACCAACCAAAGAAACGAGTACGACAGGAGTCGGATCTTGGAGGGGAAACTGCAACAATTTAAATCCGAAGTCAAAAACGTTAGGAACGAGGAGAATCAGGACCTAGTGCCCGTCTCACGACTTCTGGACAATGCTTCTCAACAGCAATTCAAAGAGTTCTTTAAACGAGAAGGTGAGGAAGCCGAAGTTGGCGGTGCGAGCGAGGAAGATGAGGAAGGACTTGTGGCGAGCGGCAGCACCAGTGAGGGAAATGTTTCTGGTACGGACGAAAACAGATCAGAATCCGAGACGACTCAACCGGTGAAGAAAAAATCTGCCTATTCCCTGGCACCGAACCGCGTCAGCTGTCCCTACTGCAGCCGCAAATTCCCGTGGACCTCTTCCTTACGAAGACACATCCTGACCCACACCGGCCAGAAACCGTTCAAGTGCAGCCACTGTCCCCTCCTCTTCACCACCAAATCCAACTGCGACCGTCACTTGTTACGCAAACACGGCAACACTGCAACCACCATAACCAACGACGCCGGCAACAACAACAACGCCAATTATCTGATGAGAAACGTCCCCGAGCGACCTTTCAAGTGCTCCAGCTGCCCCAGCAGCACATTCTCAACTTACTCGAACCTAAAAAAGCACATCAGCTGCAAGCATTCAACCAACGCCCAAGGAGACGACATCAAAGCTCAGGGATACGAGGCTGGCAGTTCCGAAGACGAGAAAATTCCTACCACTGAGGTGAAAAGCGATTGGGAGAACCAATTAGCGTACAGCAAGTTAAACGTGGATTTATCCCAAGCCGTACAAAACTCTGACCTGCCGTTCAAATGCCACCTGTGCGAGGGCTCTTTCTCCGAGCGCCAAGACGCCCTCGACCACATCAGAGATAGACACGCCTCCGAGTACGACTTGCTGATGTCCAAGAATGCCCTGGACACCAACGCCACCACTCCCGACGACGCCACCCACCAGGACGACGAAGAAAGTGAAATACGCGGTAAATTTCCCGACTACTCCAACAGAAAAGTGATCTGCGCGTTCTGCATGCGCAGGTTTTGGTCCGCGGAGGACTTGCGACGACACATGCGCACCCATACCGGGGAAAGGCCATTCAGCTGCGACATCTGCCGACGGAGGTTCACGCTGAAGCACAGCATGCTGAGACACCGGAAAAAGCACAATGTGAACTTCGAAAACGACAACAACAACAGCGACGAAGACGGAAACAATGTTCCTCCTGGATTCGAGAAGCATCCCAAAGAGGCGCACAAGAGCGAAAAGTCGGAGGAGTCGGATGGTACCGAAGGGGGAGACCTAATAAGCAACCTCTTAGGATTAAGAGATAGGTCCATTATAGATAAGGTTTTAACTGCTTCCGCAGATGACGCTGCGAAGCTCTTAGGGGTTAAGAATGGGGTTAAAGAATAg
Protein Sequence
MQGAVFMPHNPQQGFPPPSGPIVTEMEASPSPNQMTKEALANRSDSGIFSSTTNTTIDQTDLSKNSDSDNRSDCSSPERKYVCPICDRILTSQHEFTLHIRSHNNENEVQDTEKGYTCRICQKVLSSNSSLDRHVLVHSGERPFHCKYCGDTFTTNGNMHRHMRTHSHKSDNNYESDGSVDSNSSKSTEFNNNKVEKVNSNKRKIDSPDGSSKRLRDNCSDSETSQSYRCPVCERSDFNTLSNLEAHLEDNHPDYPAKCNQCNNVFLNNKQLTAHKATNHENIVSRHSVVGFKDLTFVDFSSEKFPHIARRECELNLHKVSGGLKFQCRKCTRAFPCNNSLEIHEKNCIPVEHANGLDLSTISQPEIRRMEFFSRLNLLNTSPEKQVLPLQQNKTPNKLQEHLAKAMDNTKDLADIQSILSNINLQQLQAKQGELRLPTSKSQMEHSPEFQKNEQEEESQDLFAVEFRKMKLRGEFPCRLCTAVFPNLRALKGHNRAHLNGNTNGTYHCNMCPHSSIDKAALIRHMRTHNGDRPYECSLCNYAFTTKANCERHLRNRHAKTTREEVKKSIIYHPSEDPTNDDLNKLAAKEEPKKLNIPSSSEANDLPPDKMICSTPKISDALRSHMSDIKTDMNLLKPNVTPLVQELPVLKPQKIFPNINDIIRNENLRSLKEHKMLHNGVVPLLQPNFGYTQQKIQVKSLEALKENVYDESEEEYVEEEEQPMDLVLDLSKKKCDEDSKRHREELPQDLTKKTPPPPSPVTQLPPNMGELFAQQLLKTPPKIDQAALYATQLAHFYRSGFPALSNWTGFPLNPLLFPALAPTLPQNSQDLKERMQRFQLCGGSMIAEDLKNLQNLQNLQQQSLRSPTSNYNGFKIEPKPEIKHLSTPKKPEDMKPLSLDVDTKFVDNTSKMQSPIPQIKDLMPSPNSVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHIKQQHPQFWSQRQRGSVGNPGRKAQSLPMKPSYCDLSIPNYEATRSHEYNDTKELLNEKIKLAILEQQLRASQNVNQDEKKDEDEDCELVIDENEEKPEPKTEETNQRNEYDRSRILEGKLQQFKSEVKNVRNEENQDLVPVSRLLDNASQQQFKEFFKREGEEAEVGGASEEDEEGLVASGSTSEGNVSGTDENRSESETTQPVKKKSAYSLAPNRVSCPYCSRKFPWTSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNTATTITNDAGNNNNANYLMRNVPERPFKCSSCPSSTFSTYSNLKKHISCKHSTNAQGDDIKAQGYEAGSSEDEKIPTTEVKSDWENQLAYSKLNVDLSQAVQNSDLPFKCHLCEGSFSERQDALDHIRDRHASEYDLLMSKNALDTNATTPDDATHQDDEESEIRGKFPDYSNRKVICAFCMRRFWSAEDLRRHMRTHTGERPFSCDICRRRFTLKHSMLRHRKKHNVNFENDNNNSDEDGNNVPPGFEKHPKEAHKSEKSEESDGTEGGDLISNLLGLRDRSIIDKVLTASADDAAKLLGVKNGVKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01227639;
90% Identity
iTF_01014947;
80% Identity
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