Basic Information

Gene Symbol
-
Assembly
GCA_031304115.1
Location
JAPWJP010002103.1:2267900-2270282[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00011 0.02 16.6 1.7 1 23 292 314 292 314 0.97
2 12 3e-05 0.0054 18.4 1.7 1 23 318 340 318 340 0.99
3 12 0.00028 0.051 15.3 2.9 1 23 345 367 345 367 0.96
4 12 0.00011 0.02 16.6 2.4 1 23 419 441 419 441 0.98
5 12 0.00086 0.16 13.8 1.4 1 23 446 468 446 468 0.97
6 12 0.00011 0.02 16.6 2.2 1 23 518 540 518 540 0.98
7 12 0.00033 0.06 15.1 0.9 2 23 548 569 547 569 0.97
8 12 1.1e-06 0.00019 22.9 2.1 1 23 579 601 579 601 0.96
9 12 0.00024 0.044 15.5 1.6 1 23 607 629 607 629 0.97
10 12 8.4e-05 0.015 17.0 0.8 1 23 635 657 635 657 0.97
11 12 5.1e-06 0.00093 20.8 2.0 1 23 663 685 663 685 0.96
12 12 9.2e-05 0.017 16.8 0.3 1 22 691 712 691 712 0.96

Sequence Information

Coding Sequence
ATGACTTCGGGTTACTTTACTTTGCCGATTAATATGGACAGAGTGTGCAGAATTTGTCTTACCGAAGGTACTAATCTATCACCGATCTTCTCTGCTAATCAAGAAGTAAACAATTTCTCAGGTCTCTCCCAAAAAATACAAGTCTGTGGTTCCATCGAGATACATGAACAGGATGGGTTACCTTCCTTAATTTGCGACGTTTGTATTTATAAGGCTAGCGTTGCGCACGAATTCAGACAGCAGTGTCAACATTCCGATACAAAATTACGCATGTACTATAATAAACCTGCCAAATGTAATATTACGGATTCTTGCACACAGACGGATCTACAAACGAGATTTGTACTATTGAAAAAGCCAGATCATATTGAAGAAGATTATTTTGCGAAACAAGACATGCAAGTAGTTGCAAATCCACAAGAGTACATTCAATCCACTGACTCATTTCCCAGAGGGGAAATCACtctaaataatcaaattcatATGTCAGATGACAAACTGTTTATATGTTCTATCGGATTTGAAGGGAGTAAAGAGGAAGCAAAGGATTCTTGCATATCAGAGAGCGAGGTCCATCAGATGACAATAGTGCAGGAAGATGTACAAGATGCGACTAACATTATGAATCTACAAAATAAAGATGATGAAATCAAGGAAGTTGATCAATACGTAGAGAAAGATAGTACGGAACAGGACGAGTTTATCAGCGATAACTTACCCAATGACACTgtggaagaggaagagagcaTCCCACAAAAACGTACGTCCATGAGAAAAACGAAATTGGCATCGACTAAGACATATAGCGATGACGAGATCGGCGAAAATTATTACGAGCAGAGCAGCGACAGTCAAGATTCAGTACGGTCGAAATTTAAATGCAAGGTCTGTTCCAAGCAATATGCCACGCAAAAAGGTTTAAAGAAGCATTCGTTGGTCCACGAGAAAAAGTACAAATGTAACGTCTGCTTAAAGATGTTTTATAAGCAGGAAAATATGGAGAACCATCAGAAGATACACACGTCGAAGCCGCACGCGTGTCAACTCTGTCACGCGTCATTCTCGAAACCCCAGAGTCTCGTGAGACACCTGAAATCTCACACAGAGAAGGTAAATGATATGATCAAGCAGATCAATACGAACGAACGAAAGGATAATAAGGAACCGAAAAAGGAGCTCAAGAGCGAAGATGATACTGACGACGAGACCGGACCTGCGAACGAAACGGACGAATTCGAAAACGCGCCCGAGTTGTACAAATGTGAAATTTGTAACCAATATTGTTCGTCTTTGAAGAACTTGAGGAGGCATGCCCTCGTGCACGGCGATAAGAAATACTCGTGCACTGTATGTAAGAAATGGTTCTTCAGGCCGGATACGTTGAAAAAACATGCGGAGAAACATGGACACGGATTATTGGACAATCTGGCGGATGACAATAAACTGTACGATTCGGATGACGACGATATGCCGGCTAATAACACGATGGATCCCGTGCCGGAGAGCGAGAACGtcaagagagaagagagtgATGAGGAGGGATCCGGGGAGTACAAGTGTCAGCACTGCGACAAAGTTATGGCCACCAAGAAAGGTCTGCGACGGCACGTGTCGATGCACAAGCCGAAGGCTGAACCCGTGACCTGCGATGTCTGCAGGAAGGTCTGTGCTAGTCAAGCTCGTCTTATCCTACATCAGAGAACGCACAAGCCGAAGGAGAAGGTGCCGCGCGAATACCTATGTCACATCTGCAGCAAGGTCTATCCCAGCAATTCATCCCTCACGTATCACATGCGAACTCACACCGGCGTCAAGCCGCACGTGTGCAAGACATGCAATAGCGGCttcacgacgacgacgagccTGGCGAATCACATTCGTATTCACACGGGTGACAAGCCGTTCATCTGTCACGTATGTAGCGCCGCGTTCGCCGTAAGTTCGGCTTTTCGCAGACACATGACCCGGCACACAGGCGAGGCGAATTATCTGTGCAAAACGTGCGGCAAGGCTTTCAAACGACTCAGCACGCTGAAGGAGCACACGTACACCCATTCCGGCGAGAAACCGTACGTGTGCAAGACATGCGGTGCCGCGTACAGTCATAGTGGCAGCCTCTTTGCGCATCAGAAGCGCTGTCGCGCTCAGTACGGCGAGATGATCGTCGACGAGCACAATCATCATCATCACATACCACACTCGGTCGCTCATATTCACGTGAATATGAATAACGTGAATAACGGGGCGGGAGTGCGACCGGTCGCTGTGATAGGTCAAATGTTCTAA
Protein Sequence
MTSGYFTLPINMDRVCRICLTEGTNLSPIFSANQEVNNFSGLSQKIQVCGSIEIHEQDGLPSLICDVCIYKASVAHEFRQQCQHSDTKLRMYYNKPAKCNITDSCTQTDLQTRFVLLKKPDHIEEDYFAKQDMQVVANPQEYIQSTDSFPRGEITLNNQIHMSDDKLFICSIGFEGSKEEAKDSCISESEVHQMTIVQEDVQDATNIMNLQNKDDEIKEVDQYVEKDSTEQDEFISDNLPNDTVEEEESIPQKRTSMRKTKLASTKTYSDDEIGENYYEQSSDSQDSVRSKFKCKVCSKQYATQKGLKKHSLVHEKKYKCNVCLKMFYKQENMENHQKIHTSKPHACQLCHASFSKPQSLVRHLKSHTEKVNDMIKQINTNERKDNKEPKKELKSEDDTDDETGPANETDEFENAPELYKCEICNQYCSSLKNLRRHALVHGDKKYSCTVCKKWFFRPDTLKKHAEKHGHGLLDNLADDNKLYDSDDDDMPANNTMDPVPESENVKREESDEEGSGEYKCQHCDKVMATKKGLRRHVSMHKPKAEPVTCDVCRKVCASQARLILHQRTHKPKEKVPREYLCHICSKVYPSNSSLTYHMRTHTGVKPHVCKTCNSGFTTTTSLANHIRIHTGDKPFICHVCSAAFAVSSAFRRHMTRHTGEANYLCKTCGKAFKRLSTLKEHTYTHSGEKPYVCKTCGAAYSHSGSLFAHQKRCRAQYGEMIVDEHNHHHHIPHSVAHIHVNMNNVNNGAGVRPVAVIGQMF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00264473;
90% Identity
iTF_00280113;
80% Identity
-