Basic Information

Gene Symbol
MBD2
Assembly
GCA_000349065.1
Location
KB667511.1:1480643-1482637[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.4e-24 5.9e-21 73.3 0.0 1 71 5 70 5 77 0.92
2 2 0.00033 0.8 8.8 0.0 27 73 143 200 134 203 0.84

Sequence Information

Coding Sequence
ATGAACGTATCCATCGAACGGAAGCGGACCGATTGTGCAGCTCTTCCGAAGGGCTGGCAGCGCGAAGAGGTGCTCCGAAAGACGGGCCTGTCTGCGGGGAAAGTGGATGTGTACTACTACAGTCCAACGGGGAAGAAAATTGAAAGTAAACCACAGCTCGCCCGCGCCCTCGGCGACACAATCGATCTGTCGACGTTCGACTATCAGGCGGGTCGCATTATTGCACCGCCCTCGGTGGCCGCCGCCCAGCTGCTGCACTCCCACCACGGGCCGAACTATCAACTGCTGCAGCAGCAGGCAAACAGTAGTAGTGCGCTGCGTCGGAAGTTTCCACCGTCAGTACCGCTCGGCGGAAGCAACTCCCTCACCGCTACACCAATAAGCGCTGGGTGTGGTGTGAAGCCTTCATCTCAGTTCGATTACAGCCGTGCAATGCGATCGGACACTTCACTGATCCCACCAATCAGACAAACTGCATCGATCTTCAAACAGCCGGTTACGGTGGTAAGATCGCAGGAAGCGGATAATGCCAAAGCAAAGCGTGAACTACAGCACGGCAGCCAGGTGAAACCGAAGCAGCTGTTTTGGGAGAAACGTTTAGAGAATCTCGGAGCTAGTAACACCCACAACGAAGAGATCGGCTCGATCGAACTACCGAAGCGACTGCGGCCGATAGGGCCGGGTATACGTGAAACGACGGTGCTGCAGTCGCTAGCCACTGCCCTACACCACAACACACTTCCCGTGACTGGACAGACGGCCTCGAAAACGTCGCTCAACACTAACGCGGGCGTGTTCACCAATCCACACCAGCCGCTAATGACGAATGTGACCATCACGGAGGAGGACGTTAAGCGGCAGGAGGAGCGCGTGCAGTATGCCCGGTTACGGCTACAGGAGGCGTTGCGTGCCTAA
Protein Sequence
MNVSIERKRTDCAALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIESKPQLARALGDTIDLSTFDYQAGRIIAPPSVAAAQLLHSHHGPNYQLLQQQANSSSALRRKFPPSVPLGGSNSLTATPISAGCGVKPSSQFDYSRAMRSDTSLIPPIRQTASIFKQPVTVVRSQEADNAKAKRELQHGSQVKPKQLFWEKRLENLGASNTHNEEIGSIELPKRLRPIGPGIRETTVLQSLATALHHNTLPVTGQTASKTSLNTNAGVFTNPHQPLMTNVTITEEDVKRQEERVQYARLRLQEALRA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00098998;
90% Identity
iTF_00099657;
80% Identity
-