Basic Information

Insect: Anopheles gambiae
Gene Symbol: -
Assembly: GCF_000005575.2
Location: NT:43112100-43124434[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.017 0.85 9.7 1.9 1 23 88 110 88 110 0.98

2 14 0.62 32 4.8 0.2 2 23 114 135 113 135 0.84

3 14 0.00016 0.008 16.1 1.6 1 23 147 169 147 169 0.98

4 14 6.3e-05 0.0032 17.3 0.2 2 23 173 194 173 194 0.95

5 14 5.1e-05 0.0026 17.6 1.2 1 23 208 230 208 230 0.99

6 14 0.28 14 5.9 0.1 2 23 410 432 409 432 0.91

7 14 0.11 5.5 7.2 2.6 1 21 1204 1226 1204 1228 0.93

8 14 0.51 26 5.1 0.9 2 20 1239 1258 1238 1262 0.92

9 14 2.5e-07 1.3e-05 24.9 1.4 1 23 1298 1320 1298 1320 0.98

10 14 0.0012 0.061 13.3 0.6 2 23 1387 1409 1386 1409 0.92

11 14 0.00024 0.012 15.5 1.3 1 23 1427 1449 1427 1449 0.96

12 14 0.043 2.2 8.4 6.8 1 23 1455 1477 1455 1477 0.98

13 14 0.00093 0.047 13.7 2.4 1 23 1485 1508 1485 1508 0.97

14 14 0.25 13 6.0 0.7 1 23 1517 1539 1517 1539 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.017	0.85	9.7	1.9	1	23	88	110	88	110	0.98
2	14	0.62	32	4.8	0.2	2	23	114	135	113	135	0.84
3	14	0.00016	0.008	16.1	1.6	1	23	147	169	147	169	0.98
4	14	6.3e-05	0.0032	17.3	0.2	2	23	173	194	173	194	0.95
5	14	5.1e-05	0.0026	17.6	1.2	1	23	208	230	208	230	0.99
6	14	0.28	14	5.9	0.1	2	23	410	432	409	432	0.91
7	14	0.11	5.5	7.2	2.6	1	21	1204	1226	1204	1228	0.93
8	14	0.51	26	5.1	0.9	2	20	1239	1258	1238	1262	0.92
9	14	2.5e-07	1.3e-05	24.9	1.4	1	23	1298	1320	1298	1320	0.98
10	14	0.0012	0.061	13.3	0.6	2	23	1387	1409	1386	1409	0.92
11	14	0.00024	0.012	15.5	1.3	1	23	1427	1449	1427	1449	0.96
12	14	0.043	2.2	8.4	6.8	1	23	1455	1477	1455	1477	0.98
13	14	0.00093	0.047	13.7	2.4	1	23	1485	1508	1485	1508	0.97
14	14	0.25	13	6.0	0.7	1	23	1517	1539	1517	1539	0.98

Sequence Information

Coding Sequence: ATGGAGTTCCACGACGAGATCGTTATAGAACGCACCAAAATAATGGCCGTCAATGCGGACAATTCGTTCCAGTATGAGGAGGTACAAATCAAAGAAGAAATTGCATCTGATTCAGAGGAAATAGTACCGGTAATAAGCAACGGGAAGAAAGCAGgggcacaacaacaaagcaacagcaaacatcaCGTGCACGAAGAAGATATTCCGTGTGGCCTTTACCCATTGGAAGATAACAACAATAATGCAAAAGGCAGGGCTAAGCATCAATGCGAGAATTGCCTCGAATCGTTCGACAGTATCGTTCGCCTGCGTCGGCACGAGCGAAAGCATTGGTTGAAAAGCTGCCCAATATGCGACAAGACGGTGCAGGTGGATAATTTAAAGTTTCACATCGGTCGTATGCACGGTAGCGATGAGCGGTGTGCTGAAAAACGGCCCTTCCAGTGCACGGAATGCGATAAATCGTTTTTCCTCCCGAACCACCTGTTAGAGCATGGGCAGACGCACCAGAAGGCAAGCTGCCCGGTGTGTGGGGAATCGTTCAGACCGTCCTACCTCAAGAACCACATAGCTAGAAAGCATCCGGACGGTGACGCGGGACTTTCAAAAACCCCCACCGTGTACCGTTGCAGTGCATGCAAGCAAACGTTTGTCAGTAAATCCTTGCTCTGGACTCACCAGCAGATGCATAAGAAGCTTTCGTCGAACCATCTACACTCACCGCTGCACGATTCGCCCTGCTCGCCGACGAACCCGTACGCACCATCGTCGCCATACTTTTCCTCCATCTCGCAGCAGCCGACCGGCCACACCAGCGGACCAAACGATGTCATCCTGCCGAGCATTTTCGTCAAAATTCCGACCCAAATCAAccagcagtaccagcagcaggaaagcCGGCTGCTCCGGTCCACCCATCATAGTACCGCGAGCGAAATCAAGTGCGAGGAACGGTCGGACTCGATCAAGAGCGAGATAGCCGATACGCGGGTACGGCTGGCGGGGAATGGTCTTGCCAGCACCGACCACCGGCTGCCGGACGTGATCGATAACTATCTGAACGATACGGACCGGGTGGAGCCGGCGGAGGTGGAACCGAACGTGCGCACGTGTGACCGTTGCCCTTTTGCCACCCTTTCGGAGGTGCGGCTGAGCGAGCATCGACGCGAAAGGCATCCGGggggtggtgttggtgtagGGCCACAAGAGCCGCTGGCGGAAAAGCTAAGCTGTCCGGTGTGCGAGaacaaattctacaaaaaagcCGTGCTAGAGCTGCATCTTACCGAGGACCATGAAATGTTGGCCAGTGAGGTCGCAGCATTGGGCCACAGTACCGTCACAACCCTCCAGTCGGAAAGGAGTACTGCTCCGGAAGTTAGAATCGAACCGGCGAGCCAGCAGAACTGTGTCGAGATTCCGCCGGGACCCCCGGCTGCTACCCCTACGGCAACATCGACGGCGACACACAGCAAAAGCCGGATCTACATAAAGGACGTACAGTTGCTGAAAAAGCCGGACGTGATTGCACAGGAAAGCCATGACGCGCAGGGCCAGCAGCTGCTGTCGACGGAGCAGGAACCGTCCGCGATAGCGCACGGTACGCTACAGGACAGCCATCAGCTGTCGCTCGGCGAGGACATGCTGCCATCGCTCGATCAGTCGCTGGAGCtaccgccgcagcagcaaccatGCGCCGTCAGCGGGAACAAAATCTTCATCCGCAACGTGTCGCTGCTGCAGAATGTGAATTTCGTCGCCTCGGCGGAAAACATGCTCACGAATGGGAACGGGAATCGGTACGGtacggcaccaccaccatcaccacaaccaccaccgccgtcCTCCTACCTAAGCATGGACTGTGCGAACGATGGTTCCGGGGCGCTGCTGGACACGATCAACGGTGGGTATGGTGGAACGATTGCAGCACAACCTGCTCCATCCGCAGTAGCACAATCATCCCGGGGCAGTCGTATCTACATCAAAAACGTTGACATACTTCGGAACCACCCGCTCATAGCGCTCGATGACCCCGGGGTGCCGTGCACGAATTCGCTCTCCACGACGACGTTCAGCGAATCGATTGCGACGAGTAGGGCGAGTAGCTGCGAGAGTATCATCTGCACGTCCACACCACCGGCCACGGCGacggaacagcagcaaccaccgACCGTGCCCGTACCATCGTCCATGACGAACAGCTCCTTAGGAGCAGTGTCACAAGCGAACGATCAACCGCTTTTGCATGGCACGGAAATAAGCTATGCCACCGTTGGAGCGGATGGGATGGGAAACCCGGCCCGGCCATTGCCACTATCCGTGGATCAAGGTTCGCAGAACTTGCTGATGCTGTTTTCCACCTCGCTGGACGGTACGCCGGGCGGTGGATCGGTTGGTGAGCCTAACGTTTCCTACCTGACCGCAAGCTCCAACATGAGCGTGCAGCAGGGTGGCGAGTACGGTTCGCttccacaaccaccaccaccaccggcacagTGCGATGTTCAGCAGCAAACCACCGACGACGTACCGCAGCAACAGCCAAGGAAGAGCAAAATATTCATCAAAAACATCAGCGTGCTCAAGCAGCCGACCATTCATCTGAAGTCGGTCGACGAGGTGAATCTGATGACGTACGACGAGCTGCAGAACATACTGCCTACCGTCGGCGGGATGTCCTCCCAGGTGGGGATGGACTGTGGAGGAGACACCATTGGTGGACCATTGGAGCAGCACGAAGCACACGAACAGCACACGCTGGACGGGGCGAACCGGTTGGACAAACCGTTCGGTGGGATGATTGAAATAAACGCGCACCATTCGCCCGAGCTGGTCGAGCACGGTAATGTCGAACAGCACGGCGAtggcgacgacgatgacgtTATGGATGGGTACCACGAGTCGGATCTCGGCTACAGTGAACTGAGCGATGTGTGCGACTTTACCGAAGGTTTCAACGATCGAGACGATCccggcggaggaggaggaggaggaggagcagcaggagcCGGTGGTATCGATATGACGGCGTGCACAGCCAATGATGACACGAACCGTAACGGTCACTTGGTGGCGGAATCGACCCACTGTGAGCCAACGCTTCCGCCCGGGTCCGGCTTTACGGGCGACGTTATACTGCTGCAGGAAGAATCGGATGCAAGCGAGAAGATCACGCCGAACCACGAATGGGCCGCGATCGTCGAGCCGGCGAATGGCGGTGGGCCACCGTTGGGGCAGgacattttgcagcaaccGATGGAAATGTCTGACGGCAACGAAGCTAATCCGTTGCGACGAGAGGAAGATCTGCTGCTTGGCAACTCTCACCCTCATGTGATCAATCTCGATCCTCCCAATGAGTATCATCCACCGGTTGGCGATAGTGAAGCGATCGTACTGGCGGCTGCTGTGAATCCATCGATCGGGGAGACCCAACAACCGGTGGATGCATTAACACCATCCCAAGAAGAGGCAAATGTGTCGGCTGTCACCGCGCTTGCTGAACCAGATCGTCCCCGTACCCGTGGACGGCCAAAGGGGGCGAAACAGACCGGCATCACCAAGCTGAAGAAGCTCTACACCAACCTAACGGTCGAGGAGGAAGGCTACAAGTGTGACCTGAAGGACTGTGGCGTGCGGTTTCGCCAGCCGGATCGGCTCGACTACCACCGCAAGTGTCACGTGGTGGCGCCCGACAGCCCCAATCCCATCCACTGTCCGGAGTGTGGTTCGCTCGAGTTCCGCAACTGGAACACGCTGCACACCCATCTGTGGCGGGAGCACGCGATCGACATGGAGCTGTACGCGTGCCATCTGTGCAGCTTCAAGACGCCCGTCCTGTGCCGGCTGAACAACACGCACATGAAGATCCACTCCGAGGAGCGCAACTTCAAGTGTGCCATCTGTGGGAAAGCGTTCAAGAACAACAAGCAGCTGCGCAATCACCGCCGGTGGCATCGggaaccacagcagcagcagcagcaccagcagcagcaaccgcaacacCAAGAAGCACCCGTGGTGGAGGAGCAACAGCCGGTCAGTCAACCACCACCGGTGGAAGAACCTCCTGCGATCGGCCCAACCCAATCGAACGATGCGTCCCAGGGCGACAAACCGAAAGCGAAACCCACATCCATCCAGCAATCCACGATGAAGTGCGTCAAGTGTGGGCTGCGGTTCGCGGGCAAACGGCAGCTAAGGACGCACATGGACGCAAAGCATCCCACCGAGGCGGGCGAGCCGGGGTCGACCGGGGAGGTGAGCGCCGCCAAGCATCGCTGCCTACTGTGCGGTATGGTGTTCCGGACGCGCTACCTGCTCCAGTCACACGCGGCCAAGCACTCGGACGAGAAGCGGTTCAAGTGCGAGCATTGCGAGTACACCACCAACGACCACAACGCGTTCCGGCGGCACAAGATGCGCCACAGCACCAAGGGTGGCCATATGTACAAGTGCAGCTACTGCGATTACAGCAGCATCCAGAGCACGACCTACCGGAAGCACCTGGAGCGGATGCATGCGGAGGTCGCCTCGGCCCTGCTGTACAAGTGTGCCAAGTGTCCGTTCGTGTCGATCAGCGAGGCCAAGTATCAGCTGCATCGGACTAAACACCAGGAGGAGGGAGGGGAAGCGCGAGAGAAACCGGCGGCACTGGGGGTGGAACCGTTGCAGGGGAACGACcctgagcagcagcagcgacagtgCGAAAGCGTTAACTCGGACGTGGTGAtagtggagcagcagcagcaggatgccGTTGCGGACGGGTTGAGTGCGTCACCGATGGATGTGGAGCTGCTGGGCTTGGATGCAGCTGGCGGGGGTCTACAAATCATTCAGCATCCCATCATCCGGCCGGCAATGTTTGCGAACAATTTCTCCAAGGTGGACAACTTCTACGGCTATCAACCGGCCCAGCAGCATGGTCAGCCCTTCGCGCCTTCGCCACGTGGTATGTGCCCTTCTCCGCAAGTGTCTTGCGCGGTCGGTTTGATGCCTACGCCAACCACTCCCATTCCTGTGCCAGTGTCCGGCCAGCTAGTAACCGAGCAGCACGAGTACGTGCATCTAGCTAACGCAGTAACCGGCGATGTCCTAATGAGGGAGCTTAATTAG
Protein Sequence: MEFHDEIVIERTKIMAVNADNSFQYEEVQIKEEIASDSEEIVPVISNGKKAGAQQQSNSKHHVHEEDIPCGLYPLEDNNNNAKGRAKHQCENCLESFDSIVRLRRHERKHWLKSCPICDKTVQVDNLKFHIGRMHGSDERCAEKRPFQCTECDKSFFLPNHLLEHGQTHQKASCPVCGESFRPSYLKNHIARKHPDGDAGLSKTPTVYRCSACKQTFVSKSLLWTHQQMHKKLSSNHLHSPLHDSPCSPTNPYAPSSPYFSSISQQPTGHTSGPNDVILPSIFVKIPTQINQQYQQQESRLLRSTHHSTASEIKCEERSDSIKSEIADTRVRLAGNGLASTDHRLPDVIDNYLNDTDRVEPAEVEPNVRTCDRCPFATLSEVRLSEHRRERHPGGGVGVGPQEPLAEKLSCPVCENKFYKKAVLELHLTEDHEMLASEVAALGHSTVTTLQSERSTAPEVRIEPASQQNCVEIPPGPPAATPTATSTATHSKSRIYIKDVQLLKKPDVIAQESHDAQGQQLLSTEQEPSAIAHGTLQDSHQLSLGEDMLPSLDQSLELPPQQQPCAVSGNKIFIRNVSLLQNVNFVASAENMLTNGNGNRYGTAPPPSPQPPPPSSYLSMDCANDGSGALLDTINGGYGGTIAAQPAPSAVAQSSRGSRIYIKNVDILRNHPLIALDDPGVPCTNSLSTTTFSESIATSRASSCESIICTSTPPATATEQQQPPTVPVPSSMTNSSLGAVSQANDQPLLHGTEISYATVGADGMGNPARPLPLSVDQGSQNLLMLFSTSLDGTPGGGSVGEPNVSYLTASSNMSVQQGGEYGSLPQPPPPPAQCDVQQQTTDDVPQQQPRKSKIFIKNISVLKQPTIHLKSVDEVNLMTYDELQNILPTVGGMSSQVGMDCGGDTIGGPLEQHEAHEQHTLDGANRLDKPFGGMIEINAHHSPELVEHGNVEQHGDGDDDDVMDGYHESDLGYSELSDVCDFTEGFNDRDDPGGGGGGGGAAGAGGIDMTACTANDDTNRNGHLVAESTHCEPTLPPGSGFTGDVILLQEESDASEKITPNHEWAAIVEPANGGGPPLGQDILQQPMEMSDGNEANPLRREEDLLLGNSHPHVINLDPPNEYHPPVGDSEAIVLAAAVNPSIGETQQPVDALTPSQEEANVSAVTALAEPDRPRTRGRPKGAKQTGITKLKKLYTNLTVEEEGYKCDLKDCGVRFRQPDRLDYHRKCHVVAPDSPNPIHCPECGSLEFRNWNTLHTHLWREHAIDMELYACHLCSFKTPVLCRLNNTHMKIHSEERNFKCAICGKAFKNNKQLRNHRRWHREPQQQQQHQQQQPQHQEAPVVEEQQPVSQPPPVEEPPAIGPTQSNDASQGDKPKAKPTSIQQSTMKCVKCGLRFAGKRQLRTHMDAKHPTEAGEPGSTGEVSAAKHRCLLCGMVFRTRYLLQSHAAKHSDEKRFKCEHCEYTTNDHNAFRRHKMRHSTKGGHMYKCSYCDYSSIQSTTYRKHLERMHAEVASALLYKCAKCPFVSISEAKYQLHRTKHQEEGGEAREKPAALGVEPLQGNDPEQQQRQCESVNSDVVIVEQQQQDAVADGLSASPMDVELLGLDAAGGGLQIIQHPIIRPAMFANNFSKVDNFYGYQPAQQHGQPFAPSPRGMCPSPQVSCAVGLMPTPTTPIPVPVSGQLVTEQHEYVHLANAVTGDVLMRELN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00101288; iTF_00107306; iTF_00104751; iTF_00093791;
90% Identity: iTF_00101288;
80% Identity: -