Agam004141.1
Basic Information
- Insect
- Anopheles gambiae
- Gene Symbol
- MBD2
- Assembly
- GCF_000005575.2
- Location
- NT:47471833-47473824[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.9e-24 6e-21 73.3 0.0 1 71 5 70 5 77 0.92 2 2 0.0002 0.62 9.2 0.0 27 73 143 200 134 203 0.87
Sequence Information
- Coding Sequence
- ATGAACGTATCTATCGAACGGAAGCGGACTGATTGTGCAGCTCTGCCGAAGGGCTGGCAGCGCGAAGAGGTGCTCCGAAAGACGGGCCTGTCTGCGGGGAAAGTGGATGTGTACTACTACAGTCCAACggggaagaaaattgaaagTAAACCACAGCTCGCCCGCGCCCTCGGCGACACGATCGATCTGTCGACGTTCGACTATCAGGCGGGTCGTATTATTGCACCGCCCTCGGTGGCTGCCGCCCAGCTGCTGCACTCCCACCACGGGCCGAGCTACcaactgctgcagcagcaggcaaacAGTAGTAGTGCACTGCGCCGGAAGTTTCCACCGTCAGTACCGCTCGGCGGAAGCAACTCCCTCACCGCTACACCAATAAGCGCTGGGTGTGGTGTGAAGCCTTCATCTCAGTTCGATTACAGCCGTGCAATGCGATCGGACACCTCACTGATCCCACCAATCAGACAAACTGCATCGATCTTCAAACAGCCGGTTACGGTGGTAAGATCGCAGGAACCGGATAATGCCAAAGCAAAGCGTGAACTGCAGCACGGCAGCCAGGTGAAACCGAAGCAGTTGTTTTGGGAGAAACGTTTAGAGAATCTCGGAGCCAGTAACACCCACAACGAAGAGATCGGATCGATCGAACTACCGAAGCGACTGCGACCGATAGGGCCGGGTATACGTGAAACGACGGTGCTGCAGTCGCTAGCCACTGCCCTACACCACAACACACTTCCCGTGACTGGACAGACGGCCTCTAAAACGTCGCTCAACACTAACGCCGGCGTGTTCACCAATCCACACCAGCCGCTAATGACGAACGTGACCATCACGGAGGAGGACGTTAAGCGGCAGGAGGAGCGCGTGCAGTATGCCCGGTTACGGCTACAGGAGGCGTTGCGTGCCTAA
- Protein Sequence
- MNVSIERKRTDCAALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIESKPQLARALGDTIDLSTFDYQAGRIIAPPSVAAAQLLHSHHGPSYQLLQQQANSSSALRRKFPPSVPLGGSNSLTATPISAGCGVKPSSQFDYSRAMRSDTSLIPPIRQTASIFKQPVTVVRSQEPDNAKAKRELQHGSQVKPKQLFWEKRLENLGASNTHNEEIGSIELPKRLRPIGPGIRETTVLQSLATALHHNTLPVTGQTASKTSLNTNAGVFTNPHQPLMTNVTITEEDVKRQEERVQYARLRLQEALRA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00098998;
- 90% Identity
- iTF_00099657;
- 80% Identity
- iTF_00093453;