Afon001131.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles fontenillei
Gene Symbol
egg
Assembly
GCA_008817895.1
Location
VTWG01019208.1:23861-28483[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.6e-13 1.6e-09 36.9 0.0 10 73 827 885 820 888 0.90

Sequence Information

Coding Sequence
ATGGACAAGGATACCAATCCGTCCGCCATAATTTCCCTCGAATCGGACGAGGAGATGGAAACCAATGCAGAATCGGAAGCGACTACAACATCACAGCCCGAAAAGGAACCAGCAACTAAAGAATCTCCCAGCACTGAAAATGTGCCAAGCCCGTCGAAAGCTCCTGATAATACTAGTGTTGTAGAAAATGCGAAAGATTCCGAAATAATATgcattgatgatgatgagaaggAGCCTAGCGTACAGGAGACTCCTGAAGAGAAAGCACCGGAAGAAACTTTGCCAACTGCAGAACCAAAGTCACAACCTGAACCAGTAGCAGAATCGCAAGCGGAAAAAGATCCAGAACCGCAAGCGGAAAAAGATCCAGAATCGCAAGTGGAAAAAGAACCAGATTCGCAAGCAGATAAAGAACCAGAATcgcaaacagaaaaagaaccAGAATcgcaaacagaaaaagaaccAGGATCAGAaccaacaaaagaacaaacagcACCAGAACCAGAATCAGAATCTAATGTCACTGCACCACCCCTGGAAACGGAAAATGCGATTAATGATGGAGATGTAGAAATGCAGGAAGTGGTCCAAAAGGAGGACGAAGTGAAAAATAGTCAACCAGCTGACCCGCCAGCACCGCCAGCCTCAGATGGATCGCAGTCAGTTGCCATGACGGATGCAAATAACAAGCAAGCTGATGATGAAGCTGCAAACGAACAAGCAGACAAGCAGAACAAGCAGCAGGAACCCGTCGTAACCAATGGGAACGCTGATCAGccgaagaagagcaaaaaaccGTGCGCACCCAAATGTTGCAATACGgcgtgcaaaaagaaaaacgtacAGTTTTGTGACGCTCCCGAGTTTGCTCTGAGCTTGTACAAAGTCCCTCACAGTATTCAAGTGCAGCACTTGTGTTACGATTGCTTTGAAGAGGCGGTTTCTCGCTACGAGACACTGTCCGGATTGCTGGTAAATCATCAACCTTTGCTCTTGCACGACAACCAGCCGGAAGTGTCGGAGATACTTATGGTGTTGGATAGCAGCGATGAGGAAGACGAGGATACAGTAATAGAGCGAAAAAATGAGCCGGCCCTGCCAGGCGAAGCGGTCTCGTTGGTCGAATCCGATCTGGACGATGTCATCTATAAGTTATATGGTTCGTTGTGCTTAGACCAAATTAAATGGTCAAACTCGATCCTGATGCATGAGGCTGAACAAAATCAAGCAACTTCGGACCGCATCGAAGCACAAATGAAAACGTTAAAGTCGGCATTTCAAGACATTCAAAACAATATCTACAGCGTTCGCACGACCAAGATTGATAAGCCGGAACTCATAATCGAGGACGATGCAACGAGTGAACAAATTGCCCACGAACGCTTCCGGAGCATGTTGAGCAAAACGGAAACGCTGCACCGGGAACCGGTTCAGGTGGGCTGCCAGTACTTTGGTGTAAGAACAACCGTGCTCGCCAGCTGGACTGAATGTAAGGTGCTGGAGGTAAAATCGGATATGTATACGGTGCGTTTTCTAACAGGCGACCCAAAACCTACGGTCATTACGGCAAAGCATCTCGCCTATACAACGCCTCCCAACGTGAAGCTGCTGCTTGGTACACGCGTAGTCGCCCGAACCAGTTCCGCCACCCAGGACGGAATGAACCGTACGTTTTATGCGGGCACAGTGCTGGAATCGTTAAGCAGCTACAACAAGTACCGGTACCTCATTGTGTTGGATTCAGGCCACCCGCAGTACTCGCCGTTCACGGATGTGCGCGTGGTGTGCGATCAGTCCAAACACGTCTGGGACGATGTGCATCCCCACTCGCGTGAGTTCATTAGAAACTACATGCTGAAGAGCGGATCGGTCCGCCCGATGGTGCAAGCGCACCGGGGCCAGCGAATGATGGTCGAGATCGACGATAAATGGTTCCAGGGCACTGTGCTCGAAACCGACAGCAGTCTGGTGCGCCTTTACTTCTCGGGCATGGAGAGGAAGGAGTGGATTTACCGTGGCTCGAGCCGGCTGGCACCGCTGTACCGCGAGGTGAACACGGGCCACGCACCGAACAACAAGTTCTCCAAGTTCCAAAAGCGCAACGAACCATCGATCGAGTACATTACGCTGGAGGACGACGATAGTGAGCAGCCGCCGGAGAAGAAGGCGGCAACGATTAATCACCAACCAGCGCCCAAGATGGAAGTACCGGACACGCCGAACCGGGCGACGGCCCGCAAAAGTACGGCAAACCGGACGCTCAACAACCACAACattaacaacaataataatgtcCCCGTGTCGCTGAACCGGAACACCATCTACATCGATTGCGACCAGGACCAGTCGAACGGTAGAACGCTGCTCTACACGACCAAAAACTATCGTGGCCCGCGAAAGTTTGTACCGCACAACTGTGGCCCGAGCTGCCCGTACAAGGGTGGCAAAAACTTACGCTCGTACAATCTGCTGGCCCGGCCGCTGATCACTGGCTGGGAGCGGCACAAAACGGCCGCGCGGGGCCAGAAAAAGTCCGTCGTGCTGTACCGTGCGCCCTGCGGCCGGCGGCTGCGCAATATGGCCGAGCTGCACCAGTATCTGCGGGTGACCGATTCCCCCCTGAACGTGGAGCACTTTGACTTCGATCCCGATATCCGAGCGCTGGCAACGTTCAAAGCGGAAAACGTCTTCTTCGAATGCACCGATCTGTCGTTCGGGCTCGAGCCGATGCCGGTGCACTGCGTAAACAACTACGACAACAAGCAGCCGCCGCCGTGCGAGTACTCGACCGAGCGCATCCCCACCGAAGGCGTCAACCTGAACCTGGACAAAGAGTTCCTGTGCGGGTGCGACTGCGAAGATGACTGCACGGACAAGAGCAAATGCCAGTGCTGGCAGCTGACGCTGGCCGGCGCCAAGTACGGCTTGAAGAAGAACCAGGACATCAACACGGTGGGCTACCACTACAAGCGGCTGATGAGCCATCTGTCGACCGGCATATACGAGTGCAACGTGCAGTGCAAGTGCAAGAAGGACAAATGTCTCAACCGGGTGGTGCAGAACTCGCTCCAGACGAAGCTGCAGGTGTTCAACACGCACAACAAGGGCTGGGGCATCCGCTGCCTGAACGATGTGCCGAAGGGCAGCTTCATCTGCATCTACGCCGGCCATCTGCTGACGGAGGAGACGAGCAATCGCATCTGCGACATGAGCGACGACAAGTCGGGCGACGAGTACTTTGCCGATCTGGACTTCATCGAAACGGTGGAAAAGAGCAAGGCGGACTACGAAGCGGAAGCGTACCAGTCGGACAGGGAGGACTCAACGCCGGCCGGCAATGCGAACGATTCGGACGCGTCGGAGGATGCGATCGAGAATGGGCCATCCCCGTCGACGCACGACTCGGACGAGGAGTACACGACGAAAAGCAAACCGAGCGGAACGGTCGTCAAGACGCGGGCCCAGCTGCGAAAGGCCAGCACTACGGAGCGACCGAATGCGGCCATGTTTGGCAAAAAGTCATCCAACGACGGCGTAAATGATGAGCAAGAGTGCGTCAATCTGATACCGAATCCCGAGATGGACATGATGGACGCGTCCGGCGGACCGAACGATGAGTCGCTGTTCCGCAAGCTGTACGGCGAGAATGAGCATATCTACGTGATGGACGCGAAAAAATCGGGCAACCTTGGCCGGTACTTTAACCACTCCTGCAATCCTAATCTCTTCGTCCAGAACGTGTTTGTCGATACGCACGATCTGCGGTTCCCCTGGGTAGCGTTCTTTGCGGAGCGTAACATTACAGCCGGTACGGAATTAACGTGGAACTACAACTATGACGTGGGTTCCGTCAACGGAAAGCATCTAACCTGCAACTGTGGCGAAAAGGGCTGCAAGGGCCGATTGCTCTAA
Protein Sequence
MDKDTNPSAIISLESDEEMETNAESEATTTSQPEKEPATKESPSTENVPSPSKAPDNTSVVENAKDSEIICIDDDEKEPSVQETPEEKAPEETLPTAEPKSQPEPVAESQAEKDPEPQAEKDPESQVEKEPDSQADKEPESQTEKEPESQTEKEPGSEPTKEQTAPEPESESNVTAPPLETENAINDGDVEMQEVVQKEDEVKNSQPADPPAPPASDGSQSVAMTDANNKQADDEAANEQADKQNKQQEPVVTNGNADQPKKSKKPCAPKCCNTACKKKNVQFCDAPEFALSLYKVPHSIQVQHLCYDCFEEAVSRYETLSGLLVNHQPLLLHDNQPEVSEILMVLDSSDEEDEDTVIERKNEPALPGEAVSLVESDLDDVIYKLYGSLCLDQIKWSNSILMHEAEQNQATSDRIEAQMKTLKSAFQDIQNNIYSVRTTKIDKPELIIEDDATSEQIAHERFRSMLSKTETLHREPVQVGCQYFGVRTTVLASWTECKVLEVKSDMYTVRFLTGDPKPTVITAKHLAYTTPPNVKLLLGTRVVARTSSATQDGMNRTFYAGTVLESLSSYNKYRYLIVLDSGHPQYSPFTDVRVVCDQSKHVWDDVHPHSREFIRNYMLKSGSVRPMVQAHRGQRMMVEIDDKWFQGTVLETDSSLVRLYFSGMERKEWIYRGSSRLAPLYREVNTGHAPNNKFSKFQKRNEPSIEYITLEDDDSEQPPEKKAATINHQPAPKMEVPDTPNRATARKSTANRTLNNHNINNNNNVPVSLNRNTIYIDCDQDQSNGRTLLYTTKNYRGPRKFVPHNCGPSCPYKGGKNLRSYNLLARPLITGWERHKTAARGQKKSVVLYRAPCGRRLRNMAELHQYLRVTDSPLNVEHFDFDPDIRALATFKAENVFFECTDLSFGLEPMPVHCVNNYDNKQPPPCEYSTERIPTEGVNLNLDKEFLCGCDCEDDCTDKSKCQCWQLTLAGAKYGLKKNQDINTVGYHYKRLMSHLSTGIYECNVQCKCKKDKCLNRVVQNSLQTKLQVFNTHNKGWGIRCLNDVPKGSFICIYAGHLLTEETSNRICDMSDDKSGDEYFADLDFIETVEKSKADYEAEAYQSDREDSTPAGNANDSDASEDAIENGPSPSTHDSDEEYTTKSKPSGTVVKTRAQLRKASTTERPNAAMFGKKSSNDGVNDEQECVNLIPNPEMDMMDASGGPNDESLFRKLYGENEHIYVMDAKKSGNLGRYFNHSCNPNLFVQNVFVDTHDLRFPWVAFFAERNITAGTELTWNYNYDVGSVNGKHLTCNCGEKGCKGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00095650; iTF_00102363; iTF_00106987; iTF_00093457; iTF_00104374;
90% Identity
iTF_00093457;
80% Identity
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