Aara010002.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles arabiensis
Gene Symbol
egg
Assembly
GCA_016920715.1
Location
NC:3636996-3641930[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.7e-13 1.4e-09 36.9 0.0 10 73 817 875 811 878 0.90

Sequence Information

Coding Sequence
ATGGACAAGGATACCAATCCGTCCGCCATAATTTCCCTCGAATCGGACGAGGAGATGGAAACCAATGCTGAGTCGGAAGCGACTACATCACAGCCCGAAAAGGAACCAGCAACTAAAGAATCTCCCAGCACTGAAAATGTGCCAAGCCCGTCGAAAGCTCCTGATAATGCTAGTGTTGTAGAAAATGCGAAAGATTCCGAAATAATATGCATTGACGATGATGAGAAGGAGCCTAGCGTACAAGGGACTCCTGAAGAGAATGCACCGGAAGAAGCTTTGCCAACTGCAGAACCCAAGTCACAACCTGAACCAGTTGCAGAATCGCAAGCGGAAAAAGATCCAGACTCGCAAGCTGGAAAAGAACCAGAATCACaagcagaaaaagaaacagattCGCAAGCAGATAAAGAACCAGAAAcgcaaacagaaaaagaaccAGGATCAGAACCTACAAAAGAACAAACAGCACCAGAACCAGAATCTGAATCTAATGTCACTGCACCACCCCTGGAAACGGAAAATGCGATTAATGATGGAGATGTAGAAATGCAGGAAGTGGTCCAAAAGGAGGATGAAGAGAAAATTTCAGATAGTCAAGCAGCTGACCCGCCAGCACCGCCAGCCTCAGATGAATCGCAGTCAGTTGCCATGACGGATGCAAATAACAAGCAAGCTGGTGATGAAACTGCAAACGAACAAGCAGACAAGCAGAACAAGCAGCAGGAACCCGTCGTAACCAATGGCAACGCTGATCAGCcgaagaagagcaaaaaaccGTGCGCACCCAAATGTTGCAATACGgcgtgcaaaaagaaaaacgtacAGTTTTGTGATGCTCCCGAGTTTGCTCTGAGCTTGTACAAAGTCCCTCACAGTATTCAAGTGCAGCACTTGTGTTACGATTGCTTTGAAGAGGCGGTTTCTCGCTACGAGACACTGACCGGATTGCTGGTAAATCATCAACCTTTGCTATTGCACGACAACCAGCCGGACGTGGCGGAGATACTTATGGTGTTGGATAGCAGCGATGAGGAAGACGAGGATACAGTAATAGAGCGAAAAAATGAGCCGGCCCTGCCAGCCGAAGCGGTCTCGTTGGTCGAATCCGATCTGGACGATGTCATCTACAAGTTGTATGGTTCGTTGTGCTTAGACCAAATTAAATGGTCAAACTCGATCCTGCTGCATGAGGCTGAACAAAATCAAGCAACTTCGGACCGCATCGAAGCACAAATGAAAACGTTAAAATCGGCATTTCAAGACATTCAAAACAATATCTACAGCGTTCGCACGACCAAGATTGATAAGCCGGAGCTCATAATCGAGGACGATGCAACGAGTGAACAAATTGCCCACGAACGCTTCCGGAGCATGTTGAGCAAAACGGAAACGCTACACCGGGAACCGGTTCAGGTGGGCAGCCAGTACTTTGGTGTAAGAACAACCGTGCTCGCCAGCTGGACTGAATGTAAGGTGCTGGAGGTAAAATCGGATATGTATACGGTGCGTTTTCTAACCGGCGACCCGAAACCTACGGTCATTACGGCAAAGCATCTCGCATACACAACGCCTCCCAACGTGAAGCTGCTGCTTGGAACACGCGTAGTCGCTCGAACCAGTTCCCCCACCCAGGACGGACTGAACCGTACGTTTTATGCGGGCACAGTGCTGGAATCGTTAAGCAGCTACAACAAGTACCGGTACCTCATTGTGTTGGATTCGGGCCACCCGCAGTACTCGCCGTTCACGGATGTGCGCGTGGTGTGCGATCAGTCCAAACACGTCTGGGACGATGTGCATCCCCACTCGCGTGAGTTCATTAGAAACTACATGCTGAAGAGCGGATCGGTCCGCCCGATGGTGCAAGCGCACCGGGGCCAGCGAATGATGGTCGAGATCGACGATAAATGGTTCCAGGGCACTGTGCTCGAAACTGACAGCAGTCTGGTGCGCCTTTACTTCTCGGGCATGGAGAGGAAGGAGTGGATTTACCGTGGCTCGAGCCGGCTGGCACCGCTGTACCGCGAGGTGAGCACGGGCCACGCACCGAACAACAAGTTCTCCAAGTTCCAAAAGCGGAACGAACCATCGATCGAGTACATTACGCTGGAGGACGACGACAGTGAGCAGCCGCCGGAGAAGAAGGCGGCGACGGTCAATCACCAACCAGCGCCCAAGATGGAAATACCGGACACGCCGAACCGAGCGAAGGCCCGCAAGAGTACGGCAAGCCGGATGctcaacaaccacaacaataataatgtcCCCGTGTCGCTGAACCGGAACACCATCTACATCGATTGCGACCAGAACCAGTCGAACGGTAGAACGCTGAACTACACGACCAAAAACTATCGTGGGCCGCGAAAGTTTGTACCGCACAACTGTGGCCCGAGCTGCCCGTACAAGGGTGCCAAAAACTTACGCTCGTACAATCTGCTGGCCCGGCCGCTGATCACTGGCTGGGAGCGGCACAAAACGGCCGCGCGGGGCCAGAAAAAGTCCGTCGTGCTGTACCGAGCGCCCTGCGGCCGGCGGCTGCGCAATATGGCCGAGCTGCACCAGTATCTGCGGGTGACCGATTCCCCCCTGAACGTGGAGCACTTTGACTTCGATCCCGATATCCGTGCGCTGGCAACGTTCAAAGCGGAAAACGTCTTCTTCGAATGCACCGATCTGTCGTTCGGGCTCGAGCCGATGCCGGTGCACTGCGTAAACAACTACGACAACAAGCAGCCGCCGCCGTGCGAGTACTCGACCGAGCGCATCCCCACCGAAGGCGTCAACCTGAACCTGGACAAAGAGTTCCTGTGCGGGTGCGACTGCGAAGATGACTGCATGGACAAGAGCAAATGCCAGTGCTGGCAGCTGACGCTGGCCGGCGCCAAGTACGGCTTGAAGAAGAACCAGGACATCAACACGGTGGGCTACCATTACAAGCGGCTGATGAGCCATCTGTCGACCGGCATATACGAGTGCAACGTGCAGTGCAAGTGCAAAAAGGACAAATGTCTCAACCGGGTGGTGCAGAACTCGCTGCAGACGAAGCTGCAAGTGTTCAACACGCACAACAAGGGCTGGGGCATCCGCTGCCTGAACGATGTGCCGAAGGGTAGCTTCATCTGCATCTACGCCGGCCATCTGCTGACGGAAGAGACGAGCAATCGCATCATCGACATGAGCGAAGACAAGTCGGGCGACGAGTACTTTGCCGATCTGGACTTCATCGAAACGGTGGAAAAGAGCAAGGCGGACTACGAAGCGGAAGCGTACCAGTCGGACAGGGAGGACTCAACGCCGGCCGGCAATGCGAACGATTCGGACGCGTCGGAGGATGCGATCGAGAATGGGACATCCCCGTCGACGCACGACTCGGACGAGGAGTACACGACGAAAAGCAAACCGAGCGGAACGGTCGTCAAGACGCGGGCCCAGCTGCGAAAGGCCAGCACTACGGAGCGACCGAATGCGGCCATGTTTGGCAAAAAGTCATCCAACGACGGTGTAAATGATGAGCAAGAGTGCGTCAATCTGATACCGAATCCCGAGATGGACATGGACGCGTCCGGCGGACCGAACGATGAGTCGCTGTTCCGCAAGCTATACGGCGAAAATGAGCATATCTTCGTGATGGACGCGAAAAAATCGGGTAACCTTGGCCGGTACTTTAACCACTCCTGCGATCCTAATCTCTTCGTCCAGAACGTGTTTGTCGATACGCACGATCTGCGGTTCCCCTGGGTAGCGTTCTTTGCGGAGCGTAACATTAAAGCCGGTACGGAATTAACGTGGAACTATAACTATGACGTGGGTTCCGTCAAGGGAAAGCATCTAACCTGCAGCTGTGGCGAAAAGAACTGCAAGGGCCGATTGCTCTAA
Protein Sequence
MDKDTNPSAIISLESDEEMETNAESEATTSQPEKEPATKESPSTENVPSPSKAPDNASVVENAKDSEIICIDDDEKEPSVQGTPEENAPEEALPTAEPKSQPEPVAESQAEKDPDSQAGKEPESQAEKETDSQADKEPETQTEKEPGSEPTKEQTAPEPESESNVTAPPLETENAINDGDVEMQEVVQKEDEEKISDSQAADPPAPPASDESQSVAMTDANNKQAGDETANEQADKQNKQQEPVVTNGNADQPKKSKKPCAPKCCNTACKKKNVQFCDAPEFALSLYKVPHSIQVQHLCYDCFEEAVSRYETLTGLLVNHQPLLLHDNQPDVAEILMVLDSSDEEDEDTVIERKNEPALPAEAVSLVESDLDDVIYKLYGSLCLDQIKWSNSILLHEAEQNQATSDRIEAQMKTLKSAFQDIQNNIYSVRTTKIDKPELIIEDDATSEQIAHERFRSMLSKTETLHREPVQVGSQYFGVRTTVLASWTECKVLEVKSDMYTVRFLTGDPKPTVITAKHLAYTTPPNVKLLLGTRVVARTSSPTQDGLNRTFYAGTVLESLSSYNKYRYLIVLDSGHPQYSPFTDVRVVCDQSKHVWDDVHPHSREFIRNYMLKSGSVRPMVQAHRGQRMMVEIDDKWFQGTVLETDSSLVRLYFSGMERKEWIYRGSSRLAPLYREVSTGHAPNNKFSKFQKRNEPSIEYITLEDDDSEQPPEKKAATVNHQPAPKMEIPDTPNRAKARKSTASRMLNNHNNNNVPVSLNRNTIYIDCDQNQSNGRTLNYTTKNYRGPRKFVPHNCGPSCPYKGAKNLRSYNLLARPLITGWERHKTAARGQKKSVVLYRAPCGRRLRNMAELHQYLRVTDSPLNVEHFDFDPDIRALATFKAENVFFECTDLSFGLEPMPVHCVNNYDNKQPPPCEYSTERIPTEGVNLNLDKEFLCGCDCEDDCMDKSKCQCWQLTLAGAKYGLKKNQDINTVGYHYKRLMSHLSTGIYECNVQCKCKKDKCLNRVVQNSLQTKLQVFNTHNKGWGIRCLNDVPKGSFICIYAGHLLTEETSNRIIDMSEDKSGDEYFADLDFIETVEKSKADYEAEAYQSDREDSTPAGNANDSDASEDAIENGTSPSTHDSDEEYTTKSKPSGTVVKTRAQLRKASTTERPNAAMFGKKSSNDGVNDEQECVNLIPNPEMDMDASGGPNDESLFRKLYGENEHIFVMDAKKSGNLGRYFNHSCDPNLFVQNVFVDTHDLRFPWVAFFAERNIKAGTELTWNYNYDVGSVKGKHLTCSCGEKNCKGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00100958;
90% Identity
iTF_00104374; iTF_00102363; iTF_00095650; iTF_00106987; iTF_00100958;
80% Identity
-