Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.017 62 3.5 0.1 19 46 14 41 11 43 0.88

2 7 0.00039 1.4 8.8 0.0 21 52 44 75 40 76 0.88

3 7 0.042 1.5e+02 2.3 0.0 21 44 72 95 70 99 0.86

4 7 0.00048 1.7 8.5 0.0 21 46 100 125 95 133 0.90

5 7 0.0033 12 5.8 0.1 23 52 134 163 126 164 0.87

6 7 0.00057 2 8.3 0.0 21 51 160 190 158 191 0.88

7 7 0.00044 1.6 8.6 0.1 21 46 188 213 186 224 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.017	62	3.5	0.1	19	46	14	41	11	43	0.88
2	7	0.00039	1.4	8.8	0.0	21	52	44	75	40	76	0.88
3	7	0.042	1.5e+02	2.3	0.0	21	44	72	95	70	99	0.86
4	7	0.00048	1.7	8.5	0.0	21	46	100	125	95	133	0.90
5	7	0.0033	12	5.8	0.1	23	52	134	163	126	164	0.87
6	7	0.00057	2	8.3	0.0	21	51	160	190	158	191	0.88
7	7	0.00044	1.6	8.6	0.1	21	46	188	213	186	224	0.86

Coding Sequence: ATGTCACAGCAGGCGCTGGAAAGTACGGGTGTGAAAATTTCCAACTGCTCGaaaccgttcgcctgcaccgaatgcaacaaattgtttcgccaactgagcacactgaccaaccacatgaaaatacacaccggcgaaaaaccgtacaagtgcacgatctgtgggaaggagtttcgccaaacaactacactatcgaaccatATGAAAATTCATACAGGGGAAAAGCCCTTTagttgtaacttttgtgacaaacagttccgccagctaagcaccctgtcaaaccacaagaaaattcacactggagaaaaaccgttcgaatgttcggtttgcggcaaacagttccgacagtccagcacgctcaacagtcacatccggattcattcggatgataaattttGCATAAAACCCTTCAAATGCAGCATCTGTCCGAAGGAGTTCCGCCAGACGACGACCCTAGCGAATCACATCAAAATTCACACTGgtgaaaagccgtacgcctgtacgtactgcagcaaaacgtttcgccagacgggaacgctttcgaaccatctgaagattcataccggggaaaaaccgttcgagtgttcggtttgcggtaaacagttccggcagtccagtaccttgaacagtcacattcgtatccatgcggACGACAAGTATTGCAAACCTTCACAGACGGAACAGCGGTCCATTGTGACGATAAACGGTGGGCTTAATTTAAAAGATGAGGACGTCAAACCGTTCTTTGCCATGATGTAA
Protein Sequence: MSQQALESTGVKISNCSKPFACTECNKLFRQLSTLTNHMKIHTGEKPYKCTICGKEFRQTTTLSNHMKIHTGEKPFSCNFCDKQFRQLSTLSNHKKIHTGEKPFECSVCGKQFRQSSTLNSHIRIHSDDKFCIKPFKCSICPKEFRQTTTLANHIKIHTGEKPYACTYCSKTFRQTGTLSNHLKIHTGEKPFECSVCGKQFRQSSTLNSHIRIHADDKYCKPSQTEQRSIVTINGGLNLKDEDVKPFFAMM

Sequence clustering based on sequence similarity using MMseqs2