Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0092 38 4.0 0.1 22 49 16 43 11 46 0.84

2 7 0.00015 0.61 9.8 0.0 21 52 43 74 39 76 0.89

3 7 0.048 2e+02 1.7 0.0 21 44 71 94 69 98 0.86

4 7 0.00038 1.6 8.4 0.1 21 46 99 124 94 132 0.90

5 7 0.0026 11 5.7 0.0 23 49 133 159 126 162 0.86

6 7 0.00036 1.5 8.5 0.0 21 51 159 189 157 190 0.88

7 7 0.00045 1.9 8.2 0.1 21 46 187 212 185 217 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0092	38	4.0	0.1	22	49	16	43	11	46	0.84
2	7	0.00015	0.61	9.8	0.0	21	52	43	74	39	76	0.89
3	7	0.048	2e+02	1.7	0.0	21	44	71	94	69	98	0.86
4	7	0.00038	1.6	8.4	0.1	21	46	99	124	94	132	0.90
5	7	0.0026	11	5.7	0.0	23	49	133	159	126	162	0.86
6	7	0.00036	1.5	8.5	0.0	21	51	159	189	157	190	0.88
7	7	0.00045	1.9	8.2	0.1	21	46	187	212	185	217	0.90

Coding Sequence: ATGTCACAGGCGGTGGAGAGTGCCGGCGCCAAGATTGCAAATTGCTCGAAACCCTTCGAGTGTACGGAATGCCACAAACTGTTCCGGCAGCTCAGCACCCTGACCAACCACATGAAGATACACACCGGCGAGAAGCCGTAcaagtgtttgatttgtgCGAAAGAATTCCGCCAAACGACCACGCTGTCCAACCACCTGAAAATACATACCGGTGAAAAACCGTTCAACTGTACCTTCTGTGGCAAGCAGTTCCGCCAGCTGAGCACCCTGTCGAACCACCAGAAGATACATACGGGCGAAAAACCGTTCGAGTGTACGGTATGCGGCAAACAGTTCCGCCAGTCCAGCACACTCAACAGCCATATCAGGATACATTCGGATGATAAGTTCTGCATAAAACCCTTCAAATGCAGCATCTGTCCGAAGGAATTTCGCCAGACGACTACCCTTTCAAATCACATTAAAATTCACACAGGTGAAAAGCCGTACGCCTGCACGTACTGCAACAAAACGTTCCGCCAGACGGGAACGCTTTCCAATCATCTTAAGATCCACACCGGCGAAAAGCCGTTCGAATGTTCGGTATGCGGCAAACAGTTTCGTCAATCCAGTACCTTGAACAGCCACATACGTATTCACGCGGATGATAAGTATTgtaaaacatcgtcaccatcaaccCTTGGCACAACGGCGGCCGCCGGTGAGCTGAGCATTAAGCTCGAGGACATCAAACCCCTTTACACGCTGATCTAA
Protein Sequence: MSQAVESAGAKIANCSKPFECTECHKLFRQLSTLTNHMKIHTGEKPYKCLICAKEFRQTTTLSNHLKIHTGEKPFNCTFCGKQFRQLSTLSNHQKIHTGEKPFECTVCGKQFRQSSTLNSHIRIHSDDKFCIKPFKCSICPKEFRQTTTLSNHIKIHTGEKPYACTYCNKTFRQTGTLSNHLKIHTGEKPFECSVCGKQFRQSSTLNSHIRIHADDKYCKTSSPSTLGTTAAAGELSIKLEDIKPLYTLI

Sequence clustering based on sequence similarity using MMseqs2