Basic Information

Gene Symbol
RREB1
Assembly
GCA_963971345.1
Location
OZ020482.1:40816362-40830079[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0056 0.7 11.2 0.1 1 23 39 61 39 61 0.96
2 16 0.00018 0.023 15.9 0.4 1 23 76 98 76 98 0.97
3 16 8.1e-07 0.0001 23.3 1.2 1 23 104 127 104 127 0.98
4 16 0.012 1.5 10.2 0.0 1 23 221 245 221 245 0.95
5 16 0.33 42 5.6 2.1 2 23 251 273 251 273 0.94
6 16 2.1 2.7e+02 3.1 0.6 1 19 329 347 329 348 0.89
7 16 0.19 24 6.4 0.1 1 23 463 485 463 485 0.96
8 16 2.9e-05 0.0036 18.4 0.3 1 23 494 516 494 516 0.98
9 16 0.0013 0.16 13.3 2.8 1 23 522 545 522 545 0.97
10 16 0.00046 0.058 14.6 3.0 1 23 917 940 917 940 0.97
11 16 0.00067 0.084 14.1 0.1 3 23 1217 1237 1215 1237 0.97
12 16 0.59 75 4.9 6.0 1 23 1243 1266 1243 1266 0.97
13 16 0.0042 0.53 11.6 2.2 1 23 1305 1329 1305 1329 0.97
14 16 2.7 3.4e+02 2.8 4.8 1 23 1411 1434 1411 1434 0.94
15 16 0.011 1.4 10.3 0.4 2 23 1486 1507 1485 1507 0.94
16 16 1.3 1.7e+02 3.7 8.2 1 23 1513 1535 1513 1535 0.98

Sequence Information

Coding Sequence
ATGGATTACTCGACGAAAGTTACTGTCAAGGGTAGTCCCGATCAGGGACACGACAACGAATCACAAGCGGATGCTGCATCGCCATCGTCGAGTGTCGAGCTGCCAGAAAGCGCGCACCCCTGCCCCGCCTGTCCCACAGTGCTGCCCAGCTCCAGGGAGCTGACGAACCACCTGCGTGGCCACAACTCGCCCCGCAGCGGGACAGACTGCAGCGGCGAGGACGACTATTGCTGCGGGATATGCAACAAGGTGCTGAGCTCGGCGAGCTCCCTCGACAGGCACGTGCTAGTGCACTCCGGCGAGCGACCGTTCAAGTGCAAGTACTGCGAGATGGCGTTCACCACGAACGGCAACATGAACAGGCACCTGAGGACCGCGCATCGCTCCGCGTCGCCGCACAGCTGCACCGACTCGGAAGGTAGCAGCGACTCCGAGAAGCCGCCGACGAAGAGGCGGCACATCGACGAGTACAACAACAACGAGATAGCCAAGAGGAACTCGCCGGACTTGATCGACAGACAGTTGAAATCCCCGAGCCTGGCGGGTAAGCGGAGGTGCTCGGATTTCCTCAGCGACAACGAGGGCCAGAAGAGGCACAAGATCCTTCTGAACAGCTCCAGAACGGAGATGAAGTCCCGGCCGGACGACAGCCAGAACGTGTACAACTGCCCCGTGTGCGGTCGGCAAGACTTCGCCACCAGCGCCCTGCTAGAGGCGCACCTCGAGCGCAGCCATCCGGAATTCCCCGCCAAATGCGACGCCTGCAATCTGTCTTTCAAGAATCACCGGGTGCTGAACCTGCACCGATTCATGATCCATTTCGCGGAGCATTCCATCGGGAACACGGCGAGGAATCTGAGGAACTCAGTGGTGGGCTTCAACGACCTCACCTTCGTGGACTTCTCGTCGGACAAGTTCCCGGCTATCGCCAGAGCCGTTTGCGAGCAGTCATTGCATCGACCTGCCTCCGGGGAGGTGGCCAAGTTCCAGTGCTCCAAGTGCCTGCGAGCGTTCCCGTGTAGGTCGGCGTTGGACGCCCACGAGGTGGACTGCGGCACGGCCAATCCTCAGGCGAGGATGAACGACGACAACCAGTCGAGAAGGGATGACTTCTTCGCGGGCCTGGACCTGCAGAACAAGGCCGCGCTGACGGAGGCCAAGGAGGGCAAGGACCTGGCCGACATCCAGAGCATCATATCCGTCACGTCCGGCCCGATACTGCAGAACTTCCCCCGATCAGACGCTAGCACTCCAGAGAACAACATCAAGTTCAATCCCAGTGTCAGCTCCTCCGGCTCCTCCGGCACACTGTCCTCCGAGTACCACGAGGAGGAGGCACAGGACGCGTTCGCGGCTGAGTTCAGGAAGATGAAGCTGAAGGGCGAGTTCCCCTGCAGGCTCTGCACAGCGATATTTCCGAATCTCAGAGCTCTAAAGGGTCACAACAGGGCGCACATGGGCGTCGGTCCCGGGATGCCTTATCCCTGCAACATGTGCCCTTATACAAGCACCGACAAAGCCACCCTGGTGAGACACCTGAGGTCCCACAACGGCGACAGGCCCTACGAGTGCTCCCTGTGTAACTACGCCTTCACAACAAAGGCGAACTGCGAGCGCCACGTGCGCAACCGCCACGGCAAGCTGACCAGGGAGGATATCAAGAGCGTGCTGATCTACCATCCGAACGAGGACTCGACGAACGAGAGCGTGGAGAGGAGCTCGCCCAGAGTGATGAAGGACGACGTGAGGAAGAGCCTGGTCTACCCCATCGAGCGCGACGAGCTTCAGCTGCAGACGCAACTGCACTATCCCCAGGTGCCCATGGAGGGCCGCGGCGAGATCAGGATAATCGAGGAGGCGAAGCTGCACAACACCGCGATGTCGATGCACAACCATTACGAGAAGGGCGAGGCGTTCTCCAGACCGGTGCAGCCGATCGAGCTGACGCAACGGAGCCTGGACGACGGCAAGGACGCCAAGCTGGAGGAGGATCTCGAGTCAAGGTCGTCGGAGGGCAGCGTCTCTCTAGTCAGTGATACCAAATCAGATTCGCACCAAAGAATACAAGCTAGTCCGATGAACCTGAAGAAGGGCCTGAGCGTGTCCGAGAACGCCGGCGAGGACGGCCCGCTGGATCTGTCGATGGACGTGCTGGACCTTAGCAAGAAGTCCAAGGACAAGGAGGACGCTGACTTCGCCACCTCGCAGGACCAGTTCGGCAAAAGCCAGAAGGATCTGTACAACGCCACTAGCCAATTGTTGTTGACAGAAGCTCTGCTGAAAGCTGGACAGGGGAGCTCCCAGCCGACGTCCCTGGAGGCCCTCTACGCGAATGCCCACTTGATCTATCGGAATTTCGGGACGTTCTCGGCTGGAGTCGGGGCGGGTATTCTACCACCTTATATGTTCAACCCCCATGTCTTTGGGCAGGACTTTACGATGAAGGATAGACTGCAGAAGGAGCTGGTGAGAGGCTTGCAGTTGACCAGTGGTGGGACCTTGGTGGAGCCCACTATCGGCGGAGCGGGATTCGCTGCGTTTGCCCAAGCTAGGGACATGAACAGCCAGTCTAGCAACGAGCAGAACGAGTACGCGAAGCTGATCTCGTCGAAGATCGCCAGCAAGGCTCTGTCGAACCGCGAGAAACCGGAGAATCATATTCCATCGTCGAACTCCGTGAAGATGGTGATCAAGAACGGCGTGCTGATGCCCAAACAGAAGCAACGGAGATACAGGACCGAGAGACCGTTCACGTGCGAGCATTGCTCGGCGAGATTCACCCTGAGGAGCAACATGGAGAGACACATCAAGCAGCAGCATCCTCAGCACTGGAGCCAGAGACCCAGAGGGGGCCATTCCACGAGAGGTAGGCCACCGTCCAGCCACCCGACATTGTTGCAAAATCTTGGCCAACCTGCGTCTCAGACGCAGTCCTATCAAAATATCCTGCCTAAGGTGGACCAGTCGGCGAGCTCCGAGCACACGAAGCATCCCATCTCGGACCAAGTGAAGTACGCGATTCTGGCGCAGCAGTTGAAGGCCAACAAGGTGGAAGAGAATGACTCGGAGGAGGAGCTGGTGATCGACGAGGACCCGGGAGAGAAAGGTGCACAGGAATCTCAGGAGCAGAAGAAAGAAAGCTCCAGTTTGCTGAGGGAGCAGTTGGAGGGCTCGGAATCTGTCAAGGAGCATATTGTGAAGGACGAGGCTGAGGAATCCACAAAGGATGCTACTGAATCGATTCACGCCGAGTCGACGAAGGACGAGGACGCTGCTGAAGATAAGAGCTCGGATACTGAGAGGCCCGCGGAGGCAGACGACAGCAGTGAGAATGGAGAGGATACGGAGTTCAAGGCAGAGCTGGACGACAAGTCTGAGAAAATGGAGGATGGCGCGACCGATCTGGCAAGCGTCTCTGAATTACTGGACAATGCTTCTCAACAGTATCAGCAATTCCAGCCGCAGTATCTGAGCGACGAAGAAGGCTTAGTCGCGTCCCATAGCGACTGTAACAACTCCGGCAGCGACGAGAAATCCGATTCTGTGAACTCGTTGAACTCCGTCAATGCTTCTTctaagaagaagaagaaaaagaagaagaagaagaagaagaagtcTGCTTACTCCATGGCGCCTAACCGGGTGATCTGCCCGTACTGCGAGCGACCGTTCCCCTGGACATCGTCCCTGAGGAGACACATCTTAACTCACACTGGACAGAAGCCCTACCAGTGCGTTCATTGCTCGCTTCTCTTCACCACCAAGTCCAACTGCGACCGTCACCTGCTGAGAAAGCACAAAGCGAACCCGAACAAGATCCGCAGGGTCAGGAACTCCTCCTCTCCCGACTCCCAAGCAGTGATCAGCAACAATAACTCCTCCTTTTCCATGAGGAATGTGCCCGAGAGACCGTACAAGTGCAACCAGTGCCCAAGCTCGACTTTTTCCACCCTGGGCAACTTGAAGAAGCATCGCTCGACGAAGCACGCGCGCAAGCTGAAGTCCAGGTCCGACACTCCGTCCAGCGAGCCTCAGAACAGCCCTCAGGAGTGCCCGAAGCAAGAGCAGAGCGACTACGATAGCCAGTCTTCGAGCGTGTCGGAGGGTTTGGACACCTCCTCGGTCACTGGAATCCCTAAATCGAACTCCAACACCTCAACGTCCACGAACGATACCCCTAGGTCAAGAAGACCCTCCCCAAGGTCGTCGCCAGGACCCAGCGACGTGCCCTTCAAGTGCCACCTGTGCGACTGCGGTTTCGCCGAGCGACAGGACTGTCTCGAGCACATCAAGGTGAACCACAAGAGATCGTACGAGATGCTGGTGGCGAAGGGTGCGCTGGACATGGACATCGACACCGCGGAGGACCAGCAGCAGCAGCCTCCTCCGCCACAGCATCCCAGCGATggagaagagaagagaggaCGCTTCCCGGACTACAGTAACAGGAAGGTGGTCTGCGCGTTCTGCATGAGGCGATTTTGGTCTGCCGAGGATCTGCGCCGCCACATGAGGACGCACACGGGGGAGAGGCCGTTCTCCTGCGACATATGCTGCAGGAGATTCACCCTGAAGCACAGCATGCTACGCCACAGAAAGAAACACGAGTCCATCGACTCGACCATGTACGTGGGCACCAGCGGGGACGAAGAAAACTCGCCCACGCAGCCGCCCACCATCGCGCCCCGGACGCAACAACAGCCACCCGTTTTAGTGGCGGCCAACTCTAGCAATCCCAGGATCCCGGACAGAATCTCGTTGCCCACTGTCGCCCCGGTTGCCACGGGGGACGCCGCGCCCAGCGGGCTCATGAGATTCAACCCCTACGAGAAGCTGGCCACCTTGACTGGAAAGCTGGCCACCATCCCCCAGAACGTGAATCCAGAGGCTACCGAGAGCGCGGACACCGACTTGATCTCCAATCTTCTGGGGATACGGGACAAGAGCTTCATCGACAGGGTCCTCCAAGCATCGGCTGACGACGCTGCCAAGCTGTTGGGGGTGAATCACAGCCAGGAGTGA
Protein Sequence
MDYSTKVTVKGSPDQGHDNESQADAASPSSSVELPESAHPCPACPTVLPSSRELTNHLRGHNSPRSGTDCSGEDDYCCGICNKVLSSASSLDRHVLVHSGERPFKCKYCEMAFTTNGNMNRHLRTAHRSASPHSCTDSEGSSDSEKPPTKRRHIDEYNNNEIAKRNSPDLIDRQLKSPSLAGKRRCSDFLSDNEGQKRHKILLNSSRTEMKSRPDDSQNVYNCPVCGRQDFATSALLEAHLERSHPEFPAKCDACNLSFKNHRVLNLHRFMIHFAEHSIGNTARNLRNSVVGFNDLTFVDFSSDKFPAIARAVCEQSLHRPASGEVAKFQCSKCLRAFPCRSALDAHEVDCGTANPQARMNDDNQSRRDDFFAGLDLQNKAALTEAKEGKDLADIQSIISVTSGPILQNFPRSDASTPENNIKFNPSVSSSGSSGTLSSEYHEEEAQDAFAAEFRKMKLKGEFPCRLCTAIFPNLRALKGHNRAHMGVGPGMPYPCNMCPYTSTDKATLVRHLRSHNGDRPYECSLCNYAFTTKANCERHVRNRHGKLTREDIKSVLIYHPNEDSTNESVERSSPRVMKDDVRKSLVYPIERDELQLQTQLHYPQVPMEGRGEIRIIEEAKLHNTAMSMHNHYEKGEAFSRPVQPIELTQRSLDDGKDAKLEEDLESRSSEGSVSLVSDTKSDSHQRIQASPMNLKKGLSVSENAGEDGPLDLSMDVLDLSKKSKDKEDADFATSQDQFGKSQKDLYNATSQLLLTEALLKAGQGSSQPTSLEALYANAHLIYRNFGTFSAGVGAGILPPYMFNPHVFGQDFTMKDRLQKELVRGLQLTSGGTLVEPTIGGAGFAAFAQARDMNSQSSNEQNEYAKLISSKIASKALSNREKPENHIPSSNSVKMVIKNGVLMPKQKQRRYRTERPFTCEHCSARFTLRSNMERHIKQQHPQHWSQRPRGGHSTRGRPPSSHPTLLQNLGQPASQTQSYQNILPKVDQSASSEHTKHPISDQVKYAILAQQLKANKVEENDSEEELVIDEDPGEKGAQESQEQKKESSSLLREQLEGSESVKEHIVKDEAEESTKDATESIHAESTKDEDAAEDKSSDTERPAEADDSSENGEDTEFKAELDDKSEKMEDGATDLASVSELLDNASQQYQQFQPQYLSDEEGLVASHSDCNNSGSDEKSDSVNSLNSVNASSKKKKKKKKKKKKKSAYSMAPNRVICPYCERPFPWTSSLRRHILTHTGQKPYQCVHCSLLFTTKSNCDRHLLRKHKANPNKIRRVRNSSSPDSQAVISNNNSSFSMRNVPERPYKCNQCPSSTFSTLGNLKKHRSTKHARKLKSRSDTPSSEPQNSPQECPKQEQSDYDSQSSSVSEGLDTSSVTGIPKSNSNTSTSTNDTPRSRRPSPRSSPGPSDVPFKCHLCDCGFAERQDCLEHIKVNHKRSYEMLVAKGALDMDIDTAEDQQQQPPPPQHPSDGEEKRGRFPDYSNRKVVCAFCMRRFWSAEDLRRHMRTHTGERPFSCDICCRRFTLKHSMLRHRKKHESIDSTMYVGTSGDEENSPTQPPTIAPRTQQQPPVLVAANSSNPRIPDRISLPTVAPVATGDAAPSGLMRFNPYEKLATLTGKLATIPQNVNPEATESADTDLISNLLGIRDKSFIDRVLQASADDAAKLLGVNHSQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00625690;
80% Identity
-