Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_030264675.1
Location
JARJDV010011052.1:8519-12129[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2e-10 5.1e-07 29.1 0.0 5 71 485 544 481 550 0.87
2 2 0.75 1.8e+03 -1.5 0.0 47 73 623 654 620 658 0.77

Sequence Information

Coding Sequence
ATGGGTAAACGTAAATGCAGTGTGGAAGGATGCAAATCCGAATCGCATCTACCTGAACACATTGGTGTGACTTTCCACAAGATTCCGCCTAACCCAGAAATTCGACCCAAGTGGTTAAAAGAGTGTCATATTAGTGAAGACaggaaattgttatttgtttgttctcGACATTTCCTGCGCGCCGATTTCCGCAGTTTTAATGGCTCGAGGTATATGTTACGACAGGGCATTCTACCTTCGATTTTCCCATGGAACAAACACTTAAAAAAGAGTGAGAAAAACAAAGCTAAAGCCACAGATATTCCCGGCAAACGCATCAGGAAACAGAAATTGAATCCGGATTATGTCACAGGTGAAAGTAGGAAAAAGAAAACTGAACCTAAAACCAGTGAGAAAGTGCCAGAAGTAAGTGATGCCAAAAAGACATTGGAATCTGAGGGTAGTACATCTGAGGAAAGTGTGCCCCCTGTTTTGGAACCAGAGAATTTTGCTTTGCCCAAAGCTGACAATGATAACATACCAAAATTGGAACTATCCACAAAATCTGATGGGAATTTGGGACCATTCAAAAAGAGAAAAACCGAGGCcacaacaccaacaacatcaattatcaaatcaaaaattattgtgGAAGATAAATGCAGTCCATTGGAGATTAAAACACATGAAATCATGGAAAGAAGTAAGTTGAAAGAGAAGCACCATGATGACAATCAACCAACAACGCCAGTAAAATCCCTAAAAGCGTCTGATAAATCACTGGTGGATAGTCCAAAAACACCATCAACAAATGCTAAGTTATTTGAACCTCAAACGAGGATTGAAGCGCTCGACTTTAATCAAGCATGGACGCCTGCGACTGTTCTAGAAGTAGActatgaagaaaatgaaattttggttcattttgatttgtatagtaataaatatgatgaatgGATTGCAGTTAATAGCTCTTCAATACGATTTCCCAGGAAAGAAACTGCCGACGGAGAAAAACCCAACACTGAAGCACCACAAACAGTCGAGGTACTAAAATTTGAACAGGGAGATCGATGTGTTGCGTATTGGAcggaaaacaaaaagtttcCGGGATTTATTAAAGAGGTTATTGATCATGAAACGTATGTGGTCGAGTTTGATGACGGATATCTAAAAACCCTAAACGTCTCGAAGATAATGAAGGGCACAGCGTATAAACGATCCAAGAAGACGAAACAACACAGACGCATTGAAAATCGTAGATTAAATGTTCAATCTCTGTTCAAAAAACGTGTAAAATCAAGTAAATCTTTACCTTCCGTTCTGGGTAAGGGTGAGTCGACCGAATCGTCAACATCTCAAGATCCTGGATACATTTGGAGTGATAATTTATGGTATCCAACATTTGTGGGAGGCACTCCAATTGGTGTAGCATCGCATCTAAAGACGAAAAAGGGTAATAAGAGTACAGTTATTGTCAGCGATCCAAATTTACCTGAAGGATGGGAGAAACACGCAATGAAACGAGATGGAGGCAAGTGGAATTGCATAATTGTAACACCCGACGGTCGGAAACTCCGCTGTCGATCAGACATACAACGTTATGCTGCAGAAAATCCAGATTTCAAGATGGATGATTACTCTATCAATAGTTTTTTAACACCTCGACGCCACAAGCAACAATCACAAGTTGCTTCAACAAGTGCAAATCCAGATAAAACTGAACCTGATATAGAATCAACACCCCCGACCGCAGCGACGCCATCGAGAGTTGAACCACAACTGAAAATTCTGCAAGTAGATGGTGGTTTTCAATGCCCGATTGACGGATGCGGCAAGAACTTCCGGCGGGAAAATCTTGTTCAGATGCACGTTAAACATTACCACCCCGAATTCAAAAAGTATCTCGAAAGTACTCCGAATGTATTGGATCTTGTGTATCAACGCTTGCATGGAGACGATTTTGAATTGTCGCCCAGCCGTAGCAGTGGTGAATACACCAAGAAAACCTCTGCTCCAATTGACGAAATTACCaatacgaatgcgaatgaTGCATTGATATTCGAGCAAAAGAATagcgaaattaaaaagttattgacAAGTCCCTTGGACTGCTCCGAAGGTGGTTCGCAGAGTTCCACAGCGAGCACGAGTTTACCAGAGCGGAAACTTAAAGAAATATCAACAGATTCACCTACGGATCGAGGGCCTGATTTGAAAGCGTTGGCGGTTACGACCAAGAGTGGATTGAAAACAATACCACCGTTGAAAAAGATATTGGATGAAAGCGATAAGAAGGAATTGCCACGAAAGCGAAAAATTGAAGAGTTGAGTGGCGATTTCGAGGGGCAATCTAGTGATAGTGGATTGGTTGGTGAAAATGAATTCGTCatgcagcagccgccgccgattTTAGACCATATTATTGGTGAAGATGGTAAAGTCATCAAAATCGAGCACATGCGTAAGGAGGAAATCATCAATTGCACGTGCGGAATCACCGAGGAAGATGGTCTGATGATTCAGTGTGAAATTTGCATGTGTTGGCAGCATGCGCACTGCAATAATATCTATCGCGAGACGGAAGTGCCCGAGAAATATGTGTGCTATATTTGCCAACATCCGTACGGTCAGAGGActagtttgaaatatttccatgaTCAGGATTGGTTGAAGCATGGCGTCCTGCCGACGGGAAGTTACCATTACAGGGACGAAGAAGCCTGTCAAAAGCGCTTTGAGAATTTGCGCATGTCCCATGATTTGACTGGTGGATTGATAGAGTTGAAGGACTATCTGCATTCGTTGAAATTTAAAGGAAAAATTGGAGAGATGAAAAATCATCCAAAGTTGTACTTATGGTCTAAAGCTTGGGAAAAGTATAAGTTACCAGAGGAACGCAAGAAGGCTGTAGTCAAAGAGGAGCTTGATGAATCGAAAGAGAACGCGACCGAAGTTAAGGAAGAGACTGACGCGAATGATTTCTCGAATGTTCCACAACCCGAAGCGGCGATAGAAACCGCCGATTGCCGATTGAATTTGTTGGATCATATCAGCCATTGCCAGACGTTGATAGAGGACAGATTGGATTattttgaaagtaaaattaacgAACTCGTGCCAAATCCGCTGACGCCCAAGGATGAAACTGAATTCCTTCTGTGTACGTCAATGTTGGTTAAAGATCTTAGCACAATGAGGGAGTTTTCACAGTTTAGCACGTTCTGA
Protein Sequence
MGKRKCSVEGCKSESHLPEHIGVTFHKIPPNPEIRPKWLKECHISEDRKLLFVCSRHFLRADFRSFNGSRYMLRQGILPSIFPWNKHLKKSEKNKAKATDIPGKRIRKQKLNPDYVTGESRKKKTEPKTSEKVPEVSDAKKTLESEGSTSEESVPPVLEPENFALPKADNDNIPKLELSTKSDGNLGPFKKRKTEATTPTTSIIKSKIIVEDKCSPLEIKTHEIMERSKLKEKHHDDNQPTTPVKSLKASDKSLVDSPKTPSTNAKLFEPQTRIEALDFNQAWTPATVLEVDYEENEILVHFDLYSNKYDEWIAVNSSSIRFPRKETADGEKPNTEAPQTVEVLKFEQGDRCVAYWTENKKFPGFIKEVIDHETYVVEFDDGYLKTLNVSKIMKGTAYKRSKKTKQHRRIENRRLNVQSLFKKRVKSSKSLPSVLGKGESTESSTSQDPGYIWSDNLWYPTFVGGTPIGVASHLKTKKGNKSTVIVSDPNLPEGWEKHAMKRDGGKWNCIIVTPDGRKLRCRSDIQRYAAENPDFKMDDYSINSFLTPRRHKQQSQVASTSANPDKTEPDIESTPPTAATPSRVEPQLKILQVDGGFQCPIDGCGKNFRRENLVQMHVKHYHPEFKKYLESTPNVLDLVYQRLHGDDFELSPSRSSGEYTKKTSAPIDEITNTNANDALIFEQKNSEIKKLLTSPLDCSEGGSQSSTASTSLPERKLKEISTDSPTDRGPDLKALAVTTKSGLKTIPPLKKILDESDKKELPRKRKIEELSGDFEGQSSDSGLVGENEFVMQQPPPILDHIIGEDGKVIKIEHMRKEEIINCTCGITEEDGLMIQCEICMCWQHAHCNNIYRETEVPEKYVCYICQHPYGQRTSLKYFHDQDWLKHGVLPTGSYHYRDEEACQKRFENLRMSHDLTGGLIELKDYLHSLKFKGKIGEMKNHPKLYLWSKAWEKYKLPEERKKAVVKEELDESKENATEVKEETDANDFSNVPQPEAAIETADCRLNLLDHISHCQTLIEDRLDYFESKINELVPNPLTPKDETEFLLCTSMLVKDLSTMREFSQFSTF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00049274;
90% Identity
iTF_00083951;
80% Identity
iTF_00083951;