Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963978815.1
Location
OZ022219.1:10866500-10870152[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.1e-10 4.2e-07 29.3 0.0 5 71 487 546 483 556 0.85
2 2 0.86 1.7e+03 -1.5 0.0 47 73 625 656 622 660 0.77

Sequence Information

Coding Sequence
ATGGGTAAACGTAAATGCAGTGTGGATGGATGCAAATCTGAATCGCATCTCCCGGAACACATTGGTGTGACTTTTCACAAGGTTCCTCCAAACCCCGAAATTCGACCCAAGTGGTTAAAAGAGTGTCATATTAGTGAAGATAGGAAATTATTGTATGTTTGCTCTCGGCACTTTTTACGCGCAGATTTTCGCAGTTTTAATGGCTCGAAATACATGTTGCGGCAGGGTATTTTACCCTCAATCTTCCCATggaataaacatttaaaaaagagTGAAAAAACCAAAGCTAAAACCACAGACCTTCTTGGTAAACGTATCAGAAAGCAGAAACTCAATCCAGATTATGTCACTGGTGAAAGCAGGAAGAAGAAAAGTGAACCAAAAGCAAGTGAGAAAGTGCCAGATGTCAGTGATGGTAAAAAGACACAGGAATCTGAAGAAAGCACATCCGAAGAAAGCATGCCCCCTGTTTTGGAACCAGAGAATTTTGGGTTACCAAAGGTTGACAATGATAACATTCCAAAGTTGGAACTATCAACAAAATCTGATGGGAATTTGGGTCCCTTCAAAAAGAGGAAAACAGAACcagcaacaccaacaacatcaataattaaatcaaaaatcattGTTGAAGACAAGTGCAGTCCATTGGAGATTAAAACACATGAAATCATGGAGAGAAGTAAgctgaaagaaaaacaaattgatgaaaatcaacaatctCCAACAACACCAGTAAAATCCCTAAAAACATCTGAGAAGGCAGTGATGGATAGTCCTAAAACACCATCAACACATTCTAAATTATTTGAGCCTCAAACCAGGATTGAAGCTCTGGATTTTAATCAATCATGGAGACCTGCAATTATTCTAGAAGTGGActatgaagaaaatgaagtgttGGTTCATTTCGATTCATACAGTAATAAATATGATGAGTGGATTGCAATTAACAGTTCTTCAATAAGATTCCCCAAGAAAGAGACAGCTGATGGAGAAAAACCAATCAATGATCCACCAAAAGAACCagagatattaaaatttgaacaaggAGATAGATGTAATGCGTATTGGACAGAACACAAAAAGTTTCCAGGATTTATTAAAGAGGTTATTGATCATGAAACGTATGTGGTAGAGTTTGATGACGGATACCTAAAAACGTTAAACGTCTCAAAGATAATGAAGGGCACTGCATATAAACGATCCAAGAAGACAAAACAACACAGGCGGATTGAAAGTCGCAGACTAAATGTTCAAGGGCTCTTTAAAAAACGTGtaaaatctaataaatcaacaagTTCCTCTTTGGATAAGACTACGTCGAGTGAGTCGTTAACATCGCAGGAATCAGGATATATTTGGAATGATAATTTATGGTATCCAACatttGTGGGAGGAACTCCAGTTGGTGTACCATCACACATAAAGACAAAAAAGGGTAATAAGAGTACAATTATTGTCAGTGATCCAAATTTGCCTGAAGGCTGGGAGAAGCATGCAATGAAACGTGAGGCAGGCAAGTGGAACTGCATTATTGTTACTCCTGATGGCCGAAAACTACGCTGCCGATCGGACATTCAACGTTACGCAGCTGAAAATCCTGATTTCAAGATTGATGATTATTCTATCAACAGTTTTCTGATACCTCGTCGTATCAAGCAACAACCACAAGTTGCTTCGACCAGTGCAAGTCAAGAAAAATCTGAGCCCGATGTAGAAACAACACCACCATGCGCAGCGACACCGTCAAGAATTGAACCGCAGTTGAAAATTTTACAGGTTGATGGGGGATTTCAATGTCCTATTGAAGGGTGCGGCAAGAATTTCCGGCGGGAGAACCTCGTACAGATGCATGTCAAACATTATCATCCCGAATTCAAGAAATATCTCGAAAGCACTCCGAATGTCTTGGATCTGGTCTATCAACGATTGCATGGAGACGACTTTGAATTATCGCCCAGTCGAAGCAGTGGTGAATACAGTAAGAAAACCTCAGCTCCAATTGACGAAATTACGAACACTAATGCGAATGATGCATTGATATTTGAACAAAAGAATAgcgaaattaaaaagttattaaccaGCCCGTTGGATTGTTCGGAAGGTGGTTCACAGAGTTCGACAGCAAGCACAAGTTTGCCAGAACGTAAACTTAAAGAACTCTCAACAGATTCACCAACTGATCGAGGGCCTGACTTGAAAGCGTTGGCAGTTACAACCAAGAGTGGATTGAAAACGATCCCGCCGCTGAAAAAGGTCGTGGATGATAGCGATAAGAAGGATTTGCCACGAAAGCGAAAAATTGAAGAGTTGGGTGCGGATTTCGAGGGGCAATCTAGTGATAGTGGATTGCTTGGCGAAAATGAATTTGTAATGCAGCAACCACAGCCAACTTTAGACCACATTATTGGCGAAGatgGTAAAGTCATCAAAATCGAGCACATGCGTAAGGAGGAAATCATTAATTGCACTTGCGGGATCACCGAAGAGGACGGTCTGATGATTCAGTGCGAAATTTGCATGTGTTGGCAGCATGcgcattgcaataatatttatcgtGAAGTAGAAGTGCCCGAGAAATATGTGTGCTATATTTGCCAACATCCGTATGGCCAAAGGActagtttgaaatatttccatGATCAGGACTGGTTGAAGCATGGAGTTTTACCCACAGGAAGTTATCATTACAAGGATGAAGAAGTCTACCAAAAGCGCTTTGAGAATTTGCGCGTGTCTCATGATTTGACCGGTGGTCTTATAGAGTTGAAGGACTACCTGCATTCGTTGAAATATAAGGCAAAAATTGGAGAAATGAAAAATCATCCAAAATTGTATTTGTGGTCTAAACCTTGGGAAAAGTATGATTTGCCCGAGGAACGTAACAAGACTACAGTCAAAAAGGAACCTGAAGAACCAAAGGAGAATACGGAGGAAATTAAGGTAGAGAATGACGTAAATGAATTCTCGAATATTCCGCAACCGGAGGCAGCAATAGAAACGGCTGATTGCCGATTGAATCTGTTGGATCATATCAGTCATTGTCAGACGTTGATAGAAAGCCGATTGGATTactttgaaagtaaaattaacgaACTTGTGCCAAATCCGCTAACGACGAAAGACGAAAATGATTTTCTTCTCAGTACGTCAATGTTGGTTAAAGATCTCGGCACAATGAGGGAGTTTTCACAGTTTAACACGTTTTGA
Protein Sequence
MGKRKCSVDGCKSESHLPEHIGVTFHKVPPNPEIRPKWLKECHISEDRKLLYVCSRHFLRADFRSFNGSKYMLRQGILPSIFPWNKHLKKSEKTKAKTTDLLGKRIRKQKLNPDYVTGESRKKKSEPKASEKVPDVSDGKKTQESEESTSEESMPPVLEPENFGLPKVDNDNIPKLELSTKSDGNLGPFKKRKTEPATPTTSIIKSKIIVEDKCSPLEIKTHEIMERSKLKEKQIDENQQSPTTPVKSLKTSEKAVMDSPKTPSTHSKLFEPQTRIEALDFNQSWRPAIILEVDYEENEVLVHFDSYSNKYDEWIAINSSSIRFPKKETADGEKPINDPPKEPEILKFEQGDRCNAYWTEHKKFPGFIKEVIDHETYVVEFDDGYLKTLNVSKIMKGTAYKRSKKTKQHRRIESRRLNVQGLFKKRVKSNKSTSSSLDKTTSSESLTSQESGYIWNDNLWYPTFVGGTPVGVPSHIKTKKGNKSTIIVSDPNLPEGWEKHAMKREAGKWNCIIVTPDGRKLRCRSDIQRYAAENPDFKIDDYSINSFLIPRRIKQQPQVASTSASQEKSEPDVETTPPCAATPSRIEPQLKILQVDGGFQCPIEGCGKNFRRENLVQMHVKHYHPEFKKYLESTPNVLDLVYQRLHGDDFELSPSRSSGEYSKKTSAPIDEITNTNANDALIFEQKNSEIKKLLTSPLDCSEGGSQSSTASTSLPERKLKELSTDSPTDRGPDLKALAVTTKSGLKTIPPLKKVVDDSDKKDLPRKRKIEELGADFEGQSSDSGLLGENEFVMQQPQPTLDHIIGEDGKVIKIEHMRKEEIINCTCGITEEDGLMIQCEICMCWQHAHCNNIYREVEVPEKYVCYICQHPYGQRTSLKYFHDQDWLKHGVLPTGSYHYKDEEVYQKRFENLRVSHDLTGGLIELKDYLHSLKYKAKIGEMKNHPKLYLWSKPWEKYDLPEERNKTTVKKEPEEPKENTEEIKVENDVNEFSNIPQPEAAIETADCRLNLLDHISHCQTLIESRLDYFESKINELVPNPLTTKDENDFLLSTSMLVKDLGTMREFSQFNTF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00049319;
80% Identity
iTF_00049319;