Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.054 4.3 7.5 0.0 26 45 62 81 47 85 0.86

2 9 0.073 5.7 7.1 0.0 21 45 85 109 81 115 0.91

3 9 0.41 32 4.7 0.0 22 46 114 138 109 145 0.86

4 9 0.49 39 4.5 0.1 22 47 142 167 139 172 0.82

5 9 0.075 5.9 7.1 0.0 21 46 169 194 165 200 0.86

6 9 1.2 93 3.2 0.0 21 47 197 223 193 228 0.85

7 9 0.49 39 4.5 0.0 21 47 225 251 221 257 0.85

8 9 0.052 4.1 7.6 0.1 20 44 280 304 270 308 0.83

9 9 0.12 9.2 6.5 0.1 21 47 309 335 305 341 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.054	4.3	7.5	0.0	26	45	62	81	47	85	0.86
2	9	0.073	5.7	7.1	0.0	21	45	85	109	81	115	0.91
3	9	0.41	32	4.7	0.0	22	46	114	138	109	145	0.86
4	9	0.49	39	4.5	0.1	22	47	142	167	139	172	0.82
5	9	0.075	5.9	7.1	0.0	21	46	169	194	165	200	0.86
6	9	1.2	93	3.2	0.0	21	47	197	223	193	228	0.85
7	9	0.49	39	4.5	0.0	21	47	225	251	221	257	0.85
8	9	0.052	4.1	7.6	0.1	20	44	280	304	270	308	0.83
9	9	0.12	9.2	6.5	0.1	21	47	309	335	305	341	0.85

Coding Sequence: ATGGAATTAATTGAAGAACATGAGGTGAATATTGAATTTGAAATTAAAAAAGAAGAATTACACTCTACAATAGATTTACCGGATTTTAAAATCGAATTTCAAGATTCTGATGAAGAATTAAATTCAGAACGAGATTCAACAAAACAGGAACCGAGTTATAAAAATATTGCCGGTAAATCTTTTAAATGTAAAATTTGTTCGAAATATTTCACACAATCCGGTAATTTAAAAAAGCACATTAAAACTCACACTGGGGAAAAACCTTTTAAATGTGAAATTTGTTCGAAATATTTCACAGAATCCGGTAATTTAAAAACGCACATTAAAACTCACACTGGGGAAAAACGTTTTAAATGTGAAATTTGTTCGAAATGTTTCACACAATCTAGTAGTTTAAAATCGCATGTTAAAATTCACACTGGCGAGAAAGATTTTAAATGTGAAATTTGTTCACAATGTTTTTCACACTCCGGTAGTTTAAAAAGACATATTAGAACTCACACTAACGAAAAACCTTTTAAATGTAAAGTATGTTCGAAATGTTTCACAGAATCCGGTAATTTAAAATCTCATATTAAAACTCACACTGGAGAAAAACCTTTTAAATGTAAATTATGTTCGAAATGTTTCACACATTCCAGTAGTTTAAAAAGTCATATTAAAACTCACACTAACGAAAAACCTTTTAAATGCAAATTATGTTCGAAATGTTTTACAGAATCCGGTAAATTAAAAAAGCACATTAAAAGTCACACTAATGAGAAACCTTTTAAATGTGAAAATTGTTCAAAATGTTTCGCACTTTTTGATACTTTAAAAAAGCATAATAGAACTCACACTGGAGAAAAACCTTTTAAATGCAAAATTTGTTCGAAATGTTTCACAGAATCCGGTAGTTTAAATAGACATATTAGAACTCACACTGGCGAAAAACCTTTTAAATGTAAAATTTGTTCGAAATGTTTCACAGAATCCGGTAGTTTAAAAAAGCACATTAGAACTCACACGAACGAAAAACCTTTTAAATGTGAAAAATATGTTTAA
Protein Sequence: MELIEEHEVNIEFEIKKEELHSTIDLPDFKIEFQDSDEELNSERDSTKQEPSYKNIAGKSFKCKICSKYFTQSGNLKKHIKTHTGEKPFKCEICSKYFTESGNLKTHIKTHTGEKRFKCEICSKCFTQSSSLKSHVKIHTGEKDFKCEICSQCFSHSGSLKRHIRTHTNEKPFKCKVCSKCFTESGNLKSHIKTHTGEKPFKCKLCSKCFTHSSSLKSHIKTHTNEKPFKCKLCSKCFTESGKLKKHIKSHTNEKPFKCENCSKCFALFDTLKKHNRTHTGEKPFKCKICSKCFTESGSLNRHIRTHTGEKPFKCKICSKCFTESGSLKKHIRTHTNEKPFKCEKYV

Sequence clustering based on sequence similarity using MMseqs2