Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.31 24 5.1 0.0 24 47 86 109 73 114 0.81

2 7 0.0011 0.088 12.9 0.0 21 45 111 135 107 142 0.87

3 7 0.063 5 7.3 0.0 21 45 139 163 135 170 0.90

4 7 0.016 1.3 9.2 0.1 22 44 168 190 164 195 0.88

5 7 1.4 1.1e+02 3.0 0.0 22 45 196 219 192 222 0.86

6 7 0.074 5.9 7.1 0.0 21 44 223 246 219 251 0.91

7 7 0.0021 0.16 12.1 0.0 21 44 251 274 246 277 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.31	24	5.1	0.0	24	47	86	109	73	114	0.81
2	7	0.0011	0.088	12.9	0.0	21	45	111	135	107	142	0.87
3	7	0.063	5	7.3	0.0	21	45	139	163	135	170	0.90
4	7	0.016	1.3	9.2	0.1	22	44	168	190	164	195	0.88
5	7	1.4	1.1e+02	3.0	0.0	22	45	196	219	192	222	0.86
6	7	0.074	5.9	7.1	0.0	21	44	223	246	219	251	0.91
7	7	0.0021	0.16	12.1	0.0	21	44	251	274	246	277	0.90

Coding Sequence: ATGGATATTTCTGCAATAAAAGAAGAAAAAATCGAAATTATTGACGAATCAAATCCAAAATTCGACTATTTTGATCAGATGGAAAAAATTGAAGAACATGAGGTGAATCTTGATTTTGATATTAAAAAAGAAGAATTGCACTCTACAATAGATTTACCGGATTTTAAAATCCAATTTCAAGATTCTGATGAAGAATTAAATTCAGAGCGAGATTCCACAAAGCAGGAACCGAGTTATAAAATTATTGCCGATAAATCTTTTAAATGTAAAATTTGTTCGAAATGTTTCACACAATCCGGCAGTTTAAAAAATCATATTAAAACTCACACTAACGAGAAACCTTTTAAATGTAAATTATGTTCGAAATGTTTCACACAATCCGGTAATTTAAAAAGGCATATTATAACTCACACTAATGAAAAACCTTTTAAATGTAATATTTGTTCGAAATATTTCACACAATCCGGTTATTTAAAAAATCATATTAAAACTCACACTGGGGAAAAAACTTTTAAATGTAAGATTTGTTCAAAATGTTTCAAACAATCCAGTACTTTAAAAAGGCATATTATAACTCACACTAATGAAAAAACTTTTAAATGTAATATTTGTTCGAAATATTTCACACAATCGGGTCATTTAAAAATTCATATTAAAACTCACACTGGAGAAAAACCTTTTAAATGTAAATTATGTTCGAAATGTTTCACAGAATCCGGTAATTTAAAAAAGCACATTAGTACTCACATTAACGAAAAACCATTTAAATGTGAAATTTGTTCGAAATATTTTAAACAATCCCGTCATTTAAAAATTCATATAAAAAATCACTAA
Protein Sequence: MDISAIKEEKIEIIDESNPKFDYFDQMEKIEEHEVNLDFDIKKEELHSTIDLPDFKIQFQDSDEELNSERDSTKQEPSYKIIADKSFKCKICSKCFTQSGSLKNHIKTHTNEKPFKCKLCSKCFTQSGNLKRHIITHTNEKPFKCNICSKYFTQSGYLKNHIKTHTGEKTFKCKICSKCFKQSSTLKRHIITHTNEKTFKCNICSKYFTQSGHLKIHIKTHTGEKPFKCKLCSKCFTESGNLKKHISTHINEKPFKCEICSKYFKQSRHLKIHIKNH

Sequence clustering based on sequence similarity using MMseqs2