Basic Information

Gene Symbol
Rfx2
Assembly
GCA_963921955.1
Location
OY998104.1:1161127-1180187[+]

Transcription Factor Domain

TF Family
RFX
Domain
RFX domain
PFAM
PF02257
TF Group
Basic Domians group
Description
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.7e-37 1.2e-33 116.1 0.1 2 78 375 451 374 452 0.97
2 2 3 2.1e+04 -3.2 0.1 18 38 590 609 585 629 0.48

Sequence Information

Coding Sequence
ATGCTGAGAGTCATGGATAAAAATGACAACAACAAAACAGTAATTTTGTTTACACGAAGAAGCGAAAATGAAAAGTGTCCTTGGAGTCTCGAGGATTCTGCAAATTTCTTCTCCGATATGATGGACCCCTCATCTTCTCTCCAATCGTCTATATCAAAACGTGAAGGCGACTGTGATATTGGAGTTGTGGACAGGAACGAGGGACTCATTGCCATGACTACAACTGGCGCTCAGTACGCTTTAGCAGCATCAACTACTGCTGGTCATGGCGGGGGTAATTCTTCAGTTGTAGAGGTGGAGAGTAAACCAAGCGTTGTAGTTGTCACTACATCCAGTACAAGTCCAAGTGGTAGTGTTGCACAGAGCCAAGGTACAAGGGGTCAACAATTAATCACTGTTGTCACTAGTCCTGATCCATCTAGTACCAATAATCTTCAGCCTATTCagCTAGTGGTTCAGGATCCACTGGAAACAGCTGCAGATTCTTCAAACGGCTCTTCAGGTACTGCAGCTCACGTAACTGCACAAGTTGTCGTTAATACTACTCATTCAGGACAACACGCACTCATTGAATCAGACGCAGCTTCCACATCGACCGGCACAATTGTCAGTGGATCTCCTCATTACATTACAGTAACAGtgTCAGGTGACGCTGAAGCCGTGGGTTCTGAATCGGGATCCCATCCAACATATGTTCAATACGTTCAGGGAGATGGTTCAACTTATAATATTACTAATGGAGAGATgacaTATCCAGTATATGCTGTCGGCGAAGCGGGAGCTATGTACACTCCCGCCTCGAGTCAGTATTACACTCCTGCAACAACACCAGTGACTTACGCACAAgTTTCTGGACAAGGCTCCAACACAACAACGGGCCAACTTCTTTCTCAAGGTAATGGCACGTACCTGATTCAACAGAGTGTTGTGGATGGTGATCCAACGACTCACGCCTTAATTTCAGCTGCTGCAGCTCGTGCAAGTCCACAAACCGAGAGTGCgGAGGCTGTGGTTAGCGGGGGTGGAGGGGCATACTTGATCAGCGGTAATGCTGGAGGGGCAACAATCAGCGTTGAGGAGGCTGCCACAGCAGCAAACATGACGCATGCCACTAGGGTCTCCCAGGCCACCGTACAATGGCTTTTGGAGAATTACGAGACAGCGGATGGTGTATCATTACCACGTTCTACCCTTTATAATCATTATTTACGCCACTGCTCTGAGAATAAATTGGATCCAGTTAATGCAGCTAGTTTTGGTAAATTGATACGTTCAGTATTTTTGGGATTGAGAACGAGACGTTTGGGTACACGAGGCAATTCAAAGTACCATTACTACGGAATTCGAGTGAAGCCAAGTTCACCCCTGATAATGCTAAATGAAGATGGTACATCCAGACAACAATCTAGCTCAAATAATCAAACAAAACGCTTCAAATTCGTCAATCAAAAGCAAGAATCATCGTACGATAATACTCATGGTAATTCAAATGTAACATCAAATACAACAACACCACAGTATCATCAGTATTTGGGCGAGGCAAGTAGTGCTATTccagattttccagaaattatCGTAAGTCATGGCTCATCATTGCCTGAAGACTGCACATTAGAAGATATCGATACATTCAGAAGTATTTATCGTGAGCACTGCGAAGCATTTCTCGATGctgttttaaattttgaatttggcACTGTTGAGAGCCTTTGGCGAGAATTTTGGCGCAGTCAGGATAACAATAATGGTGATGAGtgtgaagaggaaaaatacttgtcaaaaacaaaattatatcaAATGTGTAAATGCTGTGAAGTACAGGAATTTATTAGAACTGTTGATTACACATTTTATCAGAATTTAGTTGAAGTTTTAATGCCAGATGTTTTGCGGCCAATTCCCAGTACTTTGACACAGTCAATAAGAAATTTTGCGAAAGGATTGGAGTCTTGGTTGACGACAGCTATGAATGATTGTCCGGAGAAAATGATGCAAATTAAGttGACAGCTGTATCCGCCTTTGCCCAAACATTGCGCCGTTACACATCATTGAATCATCTTGCACAGGCTGCACGTGCTGTACTACAAAATTCTAGTCAAATAAGTCAAATGTTGGCTGACTTGAACCGTGTTGATTTTCACAATGTCCAAGAGCAGGCTTCTTGGGTCTGCCAATGTGACTATACAGTGGTTCAGCGTTTGGAAGCGGACTTCAAAGTTACTCTGCAGCAGCAAAATTCGTTGGAGCAATGGGCAGTTTGGTTGAAAGGCGTTGTCACACAAGTTTTGAAGCCTTATGAGGGAAAACCAACGTTCGCCAAAGCTGCGAGGCAGTTTTTGCTGAAGTGGTCTTTTTACAGctcAATGGTGATTCGTGATTTAACACTCAGAAGTGCTGCAAGCTTTGGCTCCTTCCATCTCATTCGTTTGCTGTACGATGAATACATGTTTTACTTGATCGAGCATCAAGTAGCAGTGGCCACTGGAACAACTCCAATTGCTGTAATGGGAGatAAAAATCTAACTTGTCAGATGATCTCCACTTTTAGTACAACATCAAATGGAGattcATCAAATTCCAGTGCACCAAAACGCCTGAAAATAAGCTAA
Protein Sequence
MLRVMDKNDNNKTVILFTRRSENEKCPWSLEDSANFFSDMMDPSSSLQSSISKREGDCDIGVVDRNEGLIAMTTTGAQYALAASTTAGHGGGNSSVVEVESKPSVVVVTTSSTSPSGSVAQSQGTRGQQLITVVTSPDPSSTNNLQPIQLVVQDPLETAADSSNGSSGTAAHVTAQVVVNTTHSGQHALIESDAASTSTGTIVSGSPHYITVTVSGDAEAVGSESGSHPTYVQYVQGDGSTYNITNGEMTYPVYAVGEAGAMYTPASSQYYTPATTPVTYAQVSGQGSNTTTGQLLSQGNGTYLIQQSVVDGDPTTHALISAAAARASPQTESAEAVVSGGGGAYLISGNAGGATISVEEAATAANMTHATRVSQATVQWLLENYETADGVSLPRSTLYNHYLRHCSENKLDPVNAASFGKLIRSVFLGLRTRRLGTRGNSKYHYYGIRVKPSSPLIMLNEDGTSRQQSSSNNQTKRFKFVNQKQESSYDNTHGNSNVTSNTTTPQYHQYLGEASSAIPDFPEIIVSHGSSLPEDCTLEDIDTFRSIYREHCEAFLDAVLNFEFGTVESLWREFWRSQDNNNGDECEEEKYLSKTKLYQMCKCCEVQEFIRTVDYTFYQNLVEVLMPDVLRPIPSTLTQSIRNFAKGLESWLTTAMNDCPEKMMQIKLTAVSAFAQTLRRYTSLNHLAQAARAVLQNSSQISQMLADLNRVDFHNVQEQASWVCQCDYTVVQRLEADFKVTLQQQNSLEQWAVWLKGVVTQVLKPYEGKPTFAKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLIEHQVAVATGTTPIAVMGDKNLTCQMISTFSTTSNGDSSNSSAPKRLKIS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00254817;
90% Identity
iTF_00728414;
80% Identity
-